CAS 53-86-1

Indometacina

Descripción:

Indometacina es un fármaco antiinflamatorio no esteroideo (AINE) que se utiliza principalmente para aliviar el dolor, la hinchazón y la inflamación asociada con diversas condiciones, como la artritis y la gota. Se clasifica como un derivado del ácido indolacético y exhibe potentes propiedades antiinflamatorias y analgésicas. La fórmula química de Indometacina es C19H16ClN y tiene un peso molecular de aproximadamente 357.79 g/mol. Indometacina funciona inhibiendo las enzimas ciclooxigenasas (COX), que desempeñan un papel crucial en la síntesis de prostaglandinas, mediadores de la inflamación y el dolor. La sustancia se administra típicamente por vía oral, pero también se puede administrar por vía rectal o intravenosa. Indometacina es conocido por sus posibles efectos secundarios, que pueden incluir problemas gastrointestinales, riesgos cardiovasculares y deterioro renal, lo que requiere un monitoreo cuidadoso durante su uso. Su solubilidad es moderada en agua, pero es más soluble en disolventes orgánicos, lo que influye en su formulación en preparaciones farmacéuticas. En general, Indometacina sigue siendo un agente terapéutico importante en el manejo de condiciones inflamatorias.

Fórmula: C₁₉H₁₆ClNO₄

InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

Clave InChI: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Sinónimos:

• 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• Aconip
• Amuno
• Argun
• Artracin
• Artrinovo
• Artrivia
• Bonidin
• Bonidon Gel
• Catlep
• Chibro-Amuno
• Chrono-Indicid
• Chrono-Indocid 75
• Confortid
• Dolcidium
• Dolcidium PL
• Dolovin
• Durametacin
• Elmetacin
• Endol
• Flam
• Globa
• Idomethine
• Imbrilon
• Inacid
• Indacin
• Indo-Phlogont
• Indo-Rectolmin
• Indo-Tablinen
• IndoRich
• Indocid
• Indocid (pharmaceutical)
• Indocin
• Indocine
• Indocollyre
• Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
• Indomecol
• Indomed
• Indomee
• Indometacin
• Indometacina
• Indometacine
• Indomethacin Crystalline
• Indomethacin Methanol Solution
• Indomethacin Powder
• Indomethacin Usp
• Indomethacine
• Indomethine
• Indomod
• Indonol
• Indoptic
• Indoptol
• Indorektal
• Indoxen
• Indren
• Inflazon
• Infrocin
• Innamit
• Inteban
• Inteban SP
• Lausit
• Metacen
• Metartril
• Methazine
• Metindol
• Mezolin
• Microcid
• Mikametan
• Mobilan
• N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• Nsc 77541
• Reumacide
• Rheumacin LA
• Sadoreum
• Tannex
• Vital Vitacid
• Vonum
• [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 357.79

Ref: 3B-I0655

Indomethacin, 98%

CAS: 53-86-1

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 98%

Forma y color: White to pale cream, Powder

Peso molecular: 357.79

Ref: 02-A19910

Indomethacin, 99+%

CAS: 53-86-1

Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 99+%

Peso molecular: 357.8

Ref: 02-J63255

Indometacin

CAS: 53-86-1

Forma y color: Neat

Ref: 61-FOR0584.00

Indometacin 1.0 mg/ml in Acetonitrile

CAS: 53-86-1

Forma y color: Single Solution

Ref: 61-AMP0584.00-11

INDOMETACIN IMPURITY MIXTURE CRS

CAS: 53-86-1

INDOMETACIN IMPURITY MIXTURE CRS

Fórmula: C₁₇H₁₉N₃

Peso molecular: 265.3529

Ref: 41-Y0001640

INDOMETACIN CRS

CAS: 53-86-1

INDOMETACIN CRS

Fórmula: C₁₇H₁₉N₃

Forma y color: Crystalline Powder. White. Yellow. Powder.

Peso molecular: 265.3529

Ref: 41-I0200000

Indomethacin

CAS: 53-86-1

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: White Yellow Powder

Peso molecular: 357.79

Ref: 45-1341001

Indomethacin

CAS: 53-86-1

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 99.27% - 99.76%

Forma y color: Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)

Peso molecular: 357.79

Ref: TM-T0458

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: White To Off-White Solid

Peso molecular: 357.79

Ref: 4Z-I-121

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: ≥ 98.0% (dried basis)

Forma y color: White to off-white or pale pink powder

Peso molecular: 357.80

Ref: 7W-GA3090

Indomethacin

CAS: 53-86-1

Indomethacin

Pureza: ≥98%

Peso molecular: 357.79g/mol

Ref: 54-BUP19211

Indomethacin, BP grade

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: (Titration) 98.5 - 100.5 % (dried basis)

Forma y color: White to yellow powder or crystals

Peso molecular: 357.80

Ref: 7W-GP6163

Indomethacin (Indometacin) EP Impurity D

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: White To Off-White Solid

Peso molecular: 357.79

Ref: 4Z-I-1212

Indometacin

Producto controlado

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: Neat

Peso molecular: 357.79

Ref: 86-MM0584.00

Indomethacine

Producto controlado

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: Neat

Peso molecular: 357.79

Ref: 04-C14325000

Indometacin RS

CAS: 53-86-1

Forma y color: White To Pale Reddish Yellow Solid Crystals To Powder

Ref: 2K-1019000021

Indomethacin

Producto controlado

CAS: 53-86-1

Impurity Acemetacin EP Impurity B
Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Fórmula: C₁₉H₁₆ClNO₄

Forma y color: Beige

Peso molecular: 357.79

Ref: TR-I641000

Acemetacin EP Impurity B

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Peso molecular: 357.8

Ref: ST-EA-CP-A42002

Indomethacin

CAS: 53-86-1

Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.

Fórmula: C₁₉H₁₆ClNO₄

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 357.79 g/mol

Ref: 3D-FI24585