CAS 53164-05-9

Acemetacina

Descripción:

Acemetacina es un fármaco antiinflamatorio no esteroideo (AINE) que se utiliza principalmente por sus propiedades analgésicas y antiinflamatorias. Es un derivado de indometacina y se caracteriza por su capacidad para inhibir las enzimas ciclooxigenasas, que desempeñan un papel crucial en la síntesis de prostaglandinas involucradas en la inflamación y la señalización del dolor. Acemetacina se administra típicamente en forma oral y es conocido por su tolerancia gastrointestinal relativamente favorable en comparación con otros AINE. La sustancia exhibe una solubilidad moderada a alta en disolventes orgánicos, mientras que su solubilidad en agua es limitada. Su farmacocinética implica una rápida absorción y metabolismo, lo que lleva a la formación de su metabolito activo, indometacina. Acemetacina a menudo se prescribe para condiciones como artritis, trastornos musculoesqueléticos y dolor postoperatorio. Al igual que otros AINE, puede presentar riesgos de efectos secundarios cardiovasculares y gastrointestinales, lo que requiere una cuidadosa consideración de la historia clínica del paciente y los medicamentos concurrentes. En general, Acemetacina sirve como una opción efectiva en el manejo del dolor y la inflamación.

Fórmula: C₂₁H₁₈ClNO₆

InChI: InChI=1/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)

Clave InChI: InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(OCC(O)=O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Sinónimos:

• ((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
• ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
• 2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• 2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
• 2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
• Acemet
• Acemetacin [INN:BAN:JAN]
• Acemetacina
• Acemetacina [INN-Spanish]
• Acemetacine
• Acemetacine [INN-French]
• Acemetacinum
• Acemetacinum [INN-Latin]
• Acemethacin
• Acemethazine
• Acemix
• Aximeixin
• Bay f 4975
• Brn 0501672
• Emflex
• K 708
• Rantudil
• Rheumibis
• Rheutrop
• Solart
• Tv 1322
• Tvx 1322
• Tvx 3322
• Unii-5V141Xk28X
• Acemetacin
• 5-22-05-00241 (Beilstein Handbook Reference)
• Acemetacin
• 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• [1-(4-CHLORO-BENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-ACETIC ACID CARBOXYMETHYL ESTER
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacidcarboxymethyl
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacicarboxymethyl
• AURORA KA-6229
• ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic aci carboxymethyl ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid (1-(p-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic acid carboxymethyl 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid acemetacin acemetacinum acemix

Acemetacin

CAS: 53164-05-9

Fórmula: C₂₁H₁₈ClNO₆

Pureza: >98.0%(GC)(T)

Forma y color: Light yellow to Yellow to Green powder to crystal

Peso molecular: 415.83

Ref: 3B-A2452

Acemetacin

CAS: 53164-05-9

A potent inhibitor of COX-2 found to have anti-tumor activity in the colon

Fórmula: C₂₁H₁₈ClNO₆

Peso molecular: 415.83

Ref: 02-J63583

ACEMETACIN CRS

CAS: 53164-05-9

ACEMETACIN CRS

Fórmula: C₂₁H₁₈ClNO₆

Forma y color: Yellow. Powder.

Peso molecular: 415.8237

Ref: 41-Y0000810

ACEMETACIN IMPURITY MIXTURE CRS

CAS: 53164-05-9

ACEMETACIN IMPURITY MIXTURE CRS

Fórmula: C₂₁H₁₈ClNO₆

Peso molecular: 415.8237

Ref: 41-Y0000842

Acemetacin

CAS: 53164-05-9

Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin.

Fórmula: C₂₁H₁₈ClNO₆

Pureza: 99.26%

Forma y color: Light Yellow Solid

Peso molecular: 415.82

Ref: TM-T1467

Acemetacin

CAS: 53164-05-9

Fórmula: C₂₁H₁₈ClNO₆

Peso molecular: 415.83

Ref: 7W-GP9625

Acemetacin, 10mM (in DMSO)

CAS: 53164-05-9

Acemetacin, 10mM (in DMSO)

Pureza: ≥98%

Peso molecular: 415.82g/mol

Ref: 54-BUP19931

Acemetacin

CAS: 53164-05-9

Fórmula: C₂₁H₁₈ClNO₆

Forma y color: Pale Yellow Solid

Peso molecular: 415.83

Ref: 4Z-A-442

Acemetacin

CAS: 53164-05-9

Acemetacin

Pureza: ≥98%

Peso molecular: 415.82g/mol

Ref: 54-BUP17595

Acemetacin

Producto controlado

CAS: 53164-05-9

Fórmula: C₂₁H₁₈ClNO₆

Forma y color: Neat

Peso molecular: 415.82

Ref: 86-MM1728.00

Acemetacin

CAS: 53164-05-9

Fórmula: C₂₁H₁₈ClNO₆

Forma y color: Neat

Peso molecular: 415.82

Ref: 04-C10007000

Acemetacin-d4

CAS: 53164-05-9

Fórmula: C₂₁H₁₄ClNO₆D₄

Peso molecular: 419.86

Ref: 4Z-A-443

Acemetacin

Producto controlado

CAS: 53164-05-9

Applications Acemetacin is a non-steroidal anti-inflammatory agent and used to treat rheumatic disease and other musculoskeletal disorders (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Jacobi, H. and Dell, H. D.: Arzneimittelforschung 30, 1398 (1980) (2) Moore, R. A., et al.: Cochrane Database Syst Rev. 8,CD007589 (2009)

Fórmula: C₂₁H₁₈ClNO₆

Forma y color: Yellow

Peso molecular: 415.82

Ref: TR-A130700

Acemetacin

CAS: 53164-05-9

Non-steroidal anti-inflammatory drug

Fórmula: C₂₁H₁₈ClNO₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 415.82 g/mol

Ref: 3D-FA16912

Acemetacin

CAS: 53164-05-9

Forma y color: Neat

Ref: 61-FOR1728.00