CAS 548-54-9

(3E)-3-[5-(5-hidroxi-1H-indol-3-il)-2-oxo-1,2-dihidro-3H-pirrol-3-ilideno]-1,3-dihidro-2H-indol-2-ona

Descripción:

La sustancia química con el nombre "(3E)-3-[5-(5-hidroxi-1H-indol-3-il)-2-oxo-1,2-dihidro-3H-pirrol-3-ilideno]-1,3-dihidro-2H-indol-2-ona" y el número CAS "548-54-9" es conocida como Indirubina. Es un compuesto que ocurre de forma natural y pertenece a la clase de los derivados del indol, y se reconoce principalmente por su papel en la medicina tradicional china. La Indirubina exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, anticancerígenas y antivirales. Estructuralmente, presenta una disposición compleja de anillos de indol y pirrol, lo que contribuye a su reactividad química única e interacciones. La Indirubina se estudia a menudo por sus posibles aplicaciones terapéuticas, particularmente en el tratamiento de leucemia y otras malignidades. Se piensa que su mecanismo de acción implica la inhibición de las quinasas dependientes de ciclina, que son cruciales para la regulación del ciclo celular. Además, la solubilidad y estabilidad del compuesto pueden variar dependiendo del disolvente y las condiciones ambientales, influyendo en su biodisponibilidad y eficacia en contextos farmacológicos.

Fórmula: C₂₀H₁₃N₃O₃

InChI: InChI=1/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13+

Clave InChI: InChIKey=XAPNKXIRQFHCHN-QGOAFFKASA-N

SMILES: O=C1\C(\C=2C(N1)=CC=CC2)=C\3/C=C(NC3=O)C=4C=5C(NC4)=CC=C(O)C5

Sinónimos:

• (3E)-3-[1,2-Dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one
• (E)-3-[1,2-Dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one
• 1H-indol-5-ol, 3-[(3E)-2-hydroxy-3-(2-hydroxy-3H-indol-3-ylidene)-3H-pyrrol-5-yl]-
• 2-Indolinone, 3-(2-(5-hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)-
• 2H-Indol-2-one, 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-, (E)-
• 2H-indol-2-one, 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-, (3E)-
• 3-(2-(5-Hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)-2-indolinone
• 3-[2-(5-Hydroxyindol-3-yl)-5-oxopyrrolin-4-ylidene]oxindole
• 5-(5-Hydroxy-3-indolyl)-3-(3-oxindolylidene)-2-oxopyrroline
• 548-54-9
• Oxindole, 3-[2-(5-hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene]-
• V 9389
• Violacein
• (3E)-3-[5-(5-Hydroxy-1H-indol-3-yl)-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one
• 3-[5-(5-Hydroxy-1H-indole-3-yl)-2,3-dihydro-2-oxo-1H-pyrrole-3-ylidene]-1H-indole-2(2H)-one
• Anorosin
• 3-[2-(5-Hydroxy-1H-indol-3-yl)-5-oxo-2-pyrrolin-4-ylidene]-1,3-dihydro-2H-indol-2-one
• Oxindole, 3-(2-(5-hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)- (6ci)
• 3-[2-(5-Hydroxy-1H-indol-3-yl)-5-oxo-2-pyrrolin-4-ylidene]-2-indolinone
• Brn 0049923
• Violacein from Janthinobacterium lividum

Violacein

CAS: 548-54-9

Fórmula: C₂₀H₁₃N₃O₃

Pureza: ≥ 95.0%

Forma y color: Dark purple to black solid or powder

Peso molecular: 343.34

Ref: 7W-GL0855

Violacein

CAS: 548-54-9

Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.

Fórmula: C₂₀H₁₃N₃O₃

Forma y color: Solid

Peso molecular: 343.34

Ref: TM-T35751

Violacein

CAS: 548-54-9

Fórmula: C₂₀H₁₃N₃O₃

Peso molecular: 343.34

Ref: 4Z-V-068002

Violacein

Producto controlado

CAS: 548-54-9

Fórmula: C₂₀H₁₃N₃O₃

Forma y color: Neat

Peso molecular: 343.336

Ref: TR-V634450

Violacein

CAS: 548-54-9

Violacein is a model system for studying the effects of hydroxyl groups on cell lysis. It is a fatty acid that contains nitrogen atoms and has antimicrobial properties. Violacein has been shown to cause the loss of mitochondrial membrane potential in HL-60 cells, which may be due to its ability to act as a multidrug efflux pump inhibitor. Violacein also exhibits antimicrobial activity against several bacterial strains, including MRSA and methicillin-sensitive Staphylococcus aureus (MSSA). In addition, violacein has been shown to induce cell lysis in vitro via the degradation of proteins and lipids in the cytoplasm.

Fórmula: C₂₀H₁₃N₃O₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 343.3 g/mol

Ref: 3D-AAA54854