CAS 55750-62-4

Succinimidil 3-maleimidopropionato

Descripción:

Succinimidil 3-maleimidopropionato (SMP) es un compuesto químico comúnmente utilizado en aplicaciones de bioconjugación y etiquetado de proteínas. Presenta un grupo de éster succinimidilo, que es reactivo hacia grupos amina, permitiendo la formación de enlaces amida estables con proteínas u otras biomoléculas. El grupo maleimida en SMP es particularmente significativo ya que puede reaccionar selectivamente con grupos tiol, facilitando la conjugación de proteínas o péptidos que contienen residuos de cisteína. Esta doble reactividad hace que SMP sea un cruzador versátil en la investigación bioquímica y el desarrollo terapéutico. SMP es típicamente un sólido blanco a blanco amarillento y es soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO) y el dimetilformamida (DMF), pero menos soluble en agua. Es importante manejar SMP con cuidado, ya que puede ser sensible a la humedad y debe almacenarse en un lugar fresco y seco. En general, SMP es una herramienta valiosa en el campo de la bioquímica para crear conjugados estables para diversas aplicaciones, incluyendo la entrega de medicamentos y ensayos diagnósticos.

Fórmula: C₁₁H₁₀N₂O₆

InChI: InChI=1S/C11H10N2O6/c14-7-1-2-8(15)12(7)6-5-11(18)19-13-9(16)3-4-10(13)17/h1-2H,3-6H2

Clave InChI: InChIKey=JKHVDAUOODACDU-UHFFFAOYSA-N

SMILES: O(C(CCN1C(=O)C=CC1=O)=O)N2C(=O)CCC2=O

Sinónimos:

• (2,5-Dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)propanoate
• 1-{3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}-1H-pyrrole-2,5-dione
• 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• 1H-Pyrrole-2,5-dione, 1-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-
• 2,5-Dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate
• 2,5-Dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-lH-pyrrol-1-yl)propanoate
• 3-(2,5-Dioxo-2,5-dihydropyrrol-1-yl)propionic acid 2,5-dioxopyrrolidiny-1-yl ester
• 3-Maleimidopropionic acid N-hydroxysuccinimide ester
• 3-Maleimidopropionic acid N-succinimidyl ester
• 3-Maleimidopropionic acid hydroxysuccinimide ester
• BMPS (crosslinking agent)
• N-Succinimidyl 3-(N-maleimido)propionate
• Succinimidyl 3-maleimidopropanoate
• Succinimidyl 3-maleimidopropionate
• β-Maleimidopropionic acid N-hydroxysuccinimide ester

N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]

CAS: 55750-62-4

Fórmula: C₁₁H₁₀N₂O₆

Pureza: >98.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 266.21

Ref: 3B-S0427

3-Maleimidopropionic acid N-hydroxysuccinimide ester, 99%

CAS: 55750-62-4

3-Maleimidopropionic acid N-hydroxysuccinimide ester is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for la

Fórmula: C₁₁H₁₀N₂O₆

Pureza: 99%

Forma y color: White to cream or pale yellow, Powder

Peso molecular: 266.21

Ref: 02-H27329

3-Maleimidopropionic acid N-hydroxysuccinimide ester

CAS: 55750-62-4

Fórmula: C₁₁H₁₀N₂O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 266.2069

Ref: IN-DA003TCA

Maleimidopropionic acid N-hydroxysuccinimide ester

CAS: 55750-62-4

Maleimidopropionic acid N-hydroxysuccinimide ester

Fórmula: C₁₁H₁₀N₂O₆

Pureza: 99% (hplc) (Typical Value in Batch COA)

Forma y color: white to off-white powder

Peso molecular: 266.21g/mol

Ref: 54-BICL228

BMPS

CAS: 55750-62-4

BMPS, a non-cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

Fórmula: C₁₁H₁₀N₂O₆

Pureza: 99.95%

Forma y color: Solid

Peso molecular: 266.21

Ref: TM-T14668

3-Maleimidopropionic acid N-succinimidyl ester

CAS: 55750-62-4

3-Maleimidopropionic acid N-succinimidyl ester is a potent inducer of the transcriptional regulator NF-κB. It also inhibits the growth of human osteosarcoma cells and mesenchymal cells, which may be due to its activity on integrin receptors. 3-Maleimidopropionic acid N-succinimidyl ester has been shown to inhibit the growth of infectious diseases such as HIV and malaria, as well as leukemia inhibitory factor. This drug also has a chemical effect on iron homeostasis by inhibiting iron uptake in human serum and mouse liver cells.

Fórmula: C₁₁H₁₀N₂O₆

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 266.21 g/mol

Ref: 3D-FM24998

3-(Maleimido)propionic acid N-hydroxysuccinimide ester

CAS: 55750-62-4

Fórmula: C₁₁H₁₀N₂O₆

Pureza: 97.0%

Forma y color: Solid, Crystalline Powder

Peso molecular: 266.209

Ref: 10-F079912

3-Maleimidopropionic Acid N-Succinimidyl Ester

Producto controlado

CAS: 55750-62-4

Applications A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent. Also used in immunodiagnostics.Spacer Arm: 6.9 Angstroms
References Kitagawa, T., el al.: Enz. Immunoassay, 81, (1981)

Fórmula: C₁₁H₁₀N₂O₆

Forma y color: Neat

Peso molecular: 266.21

Ref: TR-M141000