CAS 55981-09-4

Nitazoxanida

Descripción:

Nitazoxanida es un compuesto antiparasitario y antiviral que se utiliza principalmente en el tratamiento de diversas infecciones, incluidas las causadas por protozoos y ciertos virus. Se clasifica como un tiazolido y exhibe un amplio espectro de actividad contra una variedad de patógenos. La estructura química de Nitazoxanida presenta un anillo de tiazol, que contribuye a sus propiedades farmacológicas. Actúa inhibiendo la enzima piruvato:ferredoxina oxidoreductasa, interrumpiendo el metabolismo energético de los organismos objetivo. Nitazoxanida se administra típicamente por vía oral y es conocido por su perfil de toxicidad relativamente bajo. A menudo se utiliza en combinación con otros medicamentos para mejorar la eficacia terapéutica. El compuesto también se está investigando por su posible uso contra diversas infecciones virales, incluidas la influenza y los coronavirus. Su solubilidad y estabilidad en diferentes entornos de pH lo hacen adecuado para la formulación en diversas formas de dosificación. En general, Nitazoxanida representa un avance significativo en el tratamiento de enfermedades infecciosas, mostrando la importancia de los compuestos químicos en la medicina moderna.

Fórmula: C₁₂H₉N₃O₅S

InChI: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

Clave InChI: InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N

SMILES: C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(OC(C)=O)C=CC=C2

Sinónimos:

• 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
• 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• Alinia
• Brn 1225475
• Cryptaz
• Daxon
• Dexidex
• Drg 0242
• Kidonax
• Mitafar
• N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester)
• NTX
• NTZ
• Nitacure
• Nitacure 500
• Nitarid
• Nitazode
• Nitazox 500
• Nitazoxanida
• Nitazoxanide
• Nixide
• Nixoran
• Nizonide
• Nsc 697855
• Pacovanton
• ParaMix
• Ph 5776
• Xerovirin-C
• acetate de o-[N-(5-nitrothiazole-2-yl)carbamoyl]phenyle
• acetato de o-[N-(5-nitrotiazol-2-il)carbamoil]fenilo
• o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat
• o-[N-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate

Nitazoxanide

CAS: 55981-09-4

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Fórmula: C₁₂H₉N₃O₅S

Forma y color: Light Yellow Yellow Powder

Peso molecular: 307.02629

Ref: 45-1463960

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.

Fórmula: C₁₂H₉N₃O₅S

Pureza: 99% - 99.93%

Forma y color: Solid

Peso molecular: 307.28

Ref: TM-T1546

Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Pureza: 98%

Forma y color: Solid

Peso molecular: 307.2820

Ref: IN-DA00I9ZK

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Pureza: 99%

Peso molecular: 307.28g/mol

Ref: 54-OR1025226

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Pureza: ≥95%

Peso molecular: 307.28g/mol

Ref: 54-BUP17783

Nitazoxanide

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 307.28

Ref: 3B-N1031

Nitazoxanide

Producto controlado

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Forma y color: Neat

Peso molecular: 307.28

Ref: 86-MM3279.00

Nitrazoxanide

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Forma y color: Neat

Peso molecular: 307.28

Ref: 04-C15552000

Nitazoxanide

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Peso molecular: 307.28

Ref: 7W-GP0229

Nitazoxanide

Producto controlado

CAS: 55981-09-4

Applications An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.
References Cavier, R., et al.: Eur. J. Med. Chem.-Chim. Ther., 13, 539 (1978), Dubreuil, L., et al.: Antimicrob. Ag. Chemother., 40, 2266 (1996), Stockis, A., et al.: Int. J. Clin. Pharmacol. Ther., 34, 349 (1996), Nathan, C., et al.: J. Med. Chem. 52, 5789 (2009); de Carvalho et. al., J. Med. Chem., 52, 5789 (2009)

Fórmula: C₁₂H₉N₃O₅S

Forma y color: Light Yellow Crystalline

Peso molecular: 307.28

Ref: TR-N490100

Nitazoxanide - Bio-X ™

CAS: 55981-09-4

Nitazoxanide acts as a noncompetitive inhibitor of the pyruvate: ferredoxin/flavodoxin oxidoreductases of various microorganism with Ki values between 2 and 10 μM. Nitazoxanide is clinically relevant for its broad-spectrum action to reduce the growth of bacteria, various parasites, and especially for its efficacy against the pathogen Helicobacter pylori. Nitazoxanide also has been shown to be effective in treating inflammatory bowel disease and acute enteritis caused by bacteria. In 2021, nitazoxanide was tested for the treatment of COVID-19 patients with mild symptoms due to its broad antiviral action.

Fórmula: C₁₂H₉N₃O₅S

Pureza: Min. 90 Area-%

Forma y color: Powder

Peso molecular: 307.28 g/mol

Ref: 3D-BN164151

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide is a prodrug that is converted to the active form, nitazoxanide triacetate, in the stomach. It inhibits the growth of infectious agents by preventing their synthesis of DNA, RNA, or protein. Nitazoxanide has been shown to be effective against persistent strains of influenza A (H1N1) and A (H3N2) as well as rotavirus. It also has been shown to have a low toxicity profile in human clinical trials. Nitazoxanide is not an anti-inflammatory agent and does not inhibit cyclooxygenase enzymes. The drug can potentially be used for treatment of cancer due to its ability to inhibit mitochondrial membrane potential, which may lead to cell death.

Fórmula: C₁₂H₉N₃O₅S

Pureza: Min. 98 Area-%

Forma y color: White Slightly Yellow Powder

Peso molecular: 307.28 g/mol

Ref: 3D-FN26229

Nitazoxanide

CAS: 55981-09-4

Fórmula: C₁₂H₉N₃O₅S

Pureza: 95.0%

Forma y color: Crystalline Powder,Powder

Peso molecular: 307.28

Ref: 10-F076695