CAS 5610-40-2
:(-)-Securinina
Descripción:
(-)-Securinina es un alcaloide que se encuentra de forma natural y se deriva de la planta Securinega suffruticosa, que pertenece a la familia Euphorbiaceae. Se caracteriza por su compleja estructura bicíclica, que presenta un anillo de piridina y un anillo de piperidina. Este compuesto exhibe una variedad de actividades biológicas, incluyendo efectos neuroprotectores, y se ha estudiado por sus posibles aplicaciones terapéuticas en trastornos neurológicos. Se sabe que (-)-Securinina interactúa con varios sistemas de neurotransmisores, influyendo particularmente en las vías gabaérgicas y glutamatérgicas, lo que puede contribuir a sus efectos en el sistema nervioso central. La sustancia se encuentra típicamente en forma cristalina y es soluble en disolventes orgánicos. Su estereoquímica es significativa, ya que el enantiómero (-) es la forma biológicamente activa. Debido a sus propiedades farmacológicas, (-)-Securinina ha despertado interés en la química medicinal y la farmacología, aunque se necesita más investigación para elucidar completamente sus mecanismos de acción y posibles aplicaciones clínicas.
Fórmula:C13H15NO2
InChI:InChI=1/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13?/m1/s1
Clave InChI:InChIKey=SWZMSZQQJRKFBP-WZRBSPASSA-N
SMILES:O=C1O[C@@]23[C@@]4(N([C@@](C2)(C=CC3=C1)[H])CCCC4)[H]
Sinónimos:- (11aR,11bS)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
- (6R,11aS,11bR)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
- (6S,11aR)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
- (6S,11aR,11bS)-9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
- 6,10-Methanopyrido[1,2-a]azepine-Δ<sup>9(6</sup><sup>H</sup><sup>),α</sup>-acetic acid, 1,2,3,4,10,10a-hexahydro-10-hydroxy-, γ-lactone
- 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-
- 9,10,11,11a-tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
- NSC 107413
- Securinan-11-one
- Securinin
- l-Securinine
- 6,10-Methanopyrido[1,2-a]azepine-Δ9(6H),α-acetic acid, 1,2,3,4,10,10a-hexahydro-10-hydroxy-, γ-lactone
- Securinine, (-)-
- Securinine
- 1,2,3,4,10,10a-Hexahydro-10-hydroxy-
- SECURININE(RG)
- Securinan-11-on
- SECURAN-11-ONE
- (2β,7S,9S)-Securinan-11-one
- Ver más sinónimos
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Encontrado 10 productos.
(6S,11Ar,11Bs)-9,10,11,11A-Tetrahydro-8H-6,11B-Methanofuro[2,3-C]Pyrido[1,2-A]Azepin-2(6H)-One
CAS:(6S,11Ar,11Bs)-9,10,11,11A-Tetrahydro-8H-6,11B-Methanofuro[2,3-C]Pyrido[1,2-A]Azepin-2(6H)-OnePureza:95%Peso molecular:217.26g/molSecurinine
CAS:Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. It is alsoia promising new monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). Securinine shows antifungal activity against some plant pathogenic fungi.Fórmula:C13H15NO2Pureza:95%~99%Peso molecular:217.268(-)-Securinine
CAS:<p>(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.</p>Fórmula:C13H15NO2Pureza:99.58% - 99.87%Forma y color:SolidPeso molecular:217.26Securinine
CAS:<p>Securinine is an alkaloid compound, which is naturally derived from the plant Securinega suffruticosa. This alkaloid is known for its diverse biological activities, primarily attributed to its interaction with neurotransmitter systems. The mode of action of securinine involves modulation of the central nervous system, where it acts as a GABA receptor antagonist. By inhibiting the action of gamma-aminobutyric acid, securinine can influence neuronal excitability and has been studied for its neurostimulant properties.</p>Fórmula:C13H15NO2Pureza:Min. 95%Peso molecular:217.26 g/molSecurinine
CAS:Producto controlado<p>Applications Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.<br>References Friess, S.L., et al.: Toxicol. Appl. Pharmacol., 3, 347 (1961)<br></p>Fórmula:C13H15NO2Forma y color:NeatPeso molecular:217.26
![(6S,11Ar,11Bs)-9,10,11,11A-Tetrahydro-8H-6,11B-Methanofuro[2,3-C]Pyrido[1,2-A]Azepin-2(6H)-One](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1024101.jpg&w=3840&q=75)
