CAS 56377-79-8

Nosiheptida

Descripción:

Nosiheptida es un antibiótico péptido cíclico que pertenece a la clase de los tiopeptidos, conocidos por sus características estructurales únicas y potentes actividades biológicas. Es producido por ciertas cepas de la bacteria *Nocardia*, y su estructura incluye una serie de aminoácidos unidos por enlaces peptídicos, a menudo presentando aminoácidos inusuales y un anillo de tiazol o oxazol. Nosiheptida exhibe fuertes propiedades antibacterianas, particularmente contra bacterias Gram-positivas, lo que lo convierte en un tema de interés en el campo de la química medicinal y el desarrollo de antibióticos. Su mecanismo de acción típicamente implica la inhibición de la síntesis de proteínas al unirse al ARN ribosómico, interrumpiendo el proceso de traducción. Además, debido a su estructura compleja, Nosiheptida ha sido estudiado por sus posibles aplicaciones en el tratamiento de infecciones causadas por cepas resistentes a los antibióticos. La investigación sobre sus propiedades farmacológicas, biosíntesis y posibles usos terapéuticos continúa siendo un área de investigación activa, destacando la importancia de los productos naturales en el descubrimiento de fármacos.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

InChI: InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)

Clave InChI: InChIKey=OQAOHXRUMXWDLQ-UHFFFAOYSA-N

SMILES: OC=1C=C2C(C=3N=C(SC3)C4NC(=O)C=5N=C(SC5)C(NC(=O)C=6N=C(C(=CC)NC(=O)C(C(C)O)NC(=O)C=7N=C2SC7)SC6)CC(O)C(=O)OCC8=C9C(C)=C(C(=O)SC4)NC9=CC=C8)=NC1C%10=NC(C(NC(C(N)=O)=C)=O)=CS%10

Sinónimos:

• Multhiomycin
• 30,32-Imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontine, nosiheptide deriv.
• Nosiheptide
• N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide
• 4-Thiazolecarboxamide, N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-

4-Thiazolecarboxamide,N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: 96%

Forma y color: Solid

Peso molecular: 1222.3570

Ref: IN-DA01CBUM

Nosiheptide

CAS: 56377-79-8

Nosiheptide, a thiopeptide antibiotic from Streptomyces actuosus, boosts animal growth; it blocks protein synthesis in bacteria.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: 95.37%

Forma y color: Solid

Peso molecular: 1222.36

Ref: TM-T16340

Nosiheptide

CAS: 56377-79-8

Nosiheptide

Pureza: ≥95%

Peso molecular: 1222.36g/mol

Ref: 54-BUP05380

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

CAS: 56377-79-8

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

Pureza: 90%

Peso molecular: 1222.36g/mol

Ref: 54-OR1023930

Nosiheptide 100 µg/mL in Acetonitrile:Dimethylsulfoxide

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Forma y color: Single Solution

Peso molecular: 1222.36

Ref: 04-A15652500DL-100

Nosiheptide (Standard)

CAS: 56377-79-8

Nosiheptide (Standard) is the standard substance of Nosiheptide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecular: 1222.36

Ref: TM-TMSM-1776

Nosiheptide

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecular: 1222.34

Ref: 4Z-PN-172001

Nosiheptide

CAS: 56377-79-8

A thiopeptide antibiotic produced by the bacterium Streptomyces actuosus. In addition, nosiheptide inhibits bacterial protein biosynthesis by acting during the elongation of the protein.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 1,222.36 g/mol

Ref: 3D-FA76383

Nosiheptide (>85%)

CAS: 56377-79-8

Applications Nosiheptide is an antibacterial item used in feedstock and feed additives for chickens.
References Wang, H. et al.: J. Sci. Food. Agri., 93, 284 (2013); Kobayashi, I. et al.: Res. Dev. Rev., 2, 53 (1988);

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Forma y color: Neat

Peso molecular: 1222.36

Ref: TR-N884000