CAS 564-36-3

Ergocornina

Descripción:

Ergocornina es un alcaloide que se encuentra de forma natural y se deriva del hongo del cornezuelo, específicamente de la especie Claviceps purpurea. Forma parte del grupo más amplio de alcaloides del cornezuelo, que son conocidos por sus estructuras complejas y diversas actividades biológicas. Ergocornina se caracteriza por su estructura tetracíclica, que incluye un marco de indol e isoquinolina fusionados. Este compuesto exhibe varias propiedades farmacológicas, incluyendo vasoconstricción y efectos sobre los sistemas de neurotransmisores, particularmente en relación con la serotonina y la dopamina. Ergocornina ha sido estudiado por sus posibles aplicaciones terapéuticas, incluyendo su papel en el tratamiento de migrañas y otros trastornos vasculares. Sin embargo, también se asocia con efectos adversos, particularmente cuando se deriva de granos contaminados, lo que lleva a la ergotismo. El compuesto se encuentra típicamente en forma cristalina y es soluble en disolventes orgánicos. Sus propiedades químicas y actividades biológicas lo convierten en un tema de interés tanto en farmacología como en toxicología. Al igual que con muchos alcaloides, las consideraciones de seguridad y dosificación son cruciales al explorar sus aplicaciones.

Fórmula: C₃₁H₃₉N₅O₅

InChI: InChI=1/C31H39N5O5/c1-16(2)26-28(38)35-11-7-10-24(35)31(40)36(26)29(39)30(41-31,17(3)4)33-27(37)19-12-21-20-8-6-9-22-25(20)18(14-32-22)13-23(21)34(5)15-19/h6,8-9,12,14,16-17,19,23-24,26,32,40H,7,10-11,13,15H2,1-5H3,(H,33,37)/t19-,23-,24+,26+,30-,31+/m1/s1

Clave InChI: InChIKey=UJYGDMFEEDNVBF-OGGGUQDZSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=CNC6C=CC5)(C(C)C)O1)[C@@H]([C@@H](C)C)C(=O)N7[C@]2(CCC7)[H]

Sinónimos:

• Ergocornine
• Ergotaman-3′,6′,18-trione, 12′-hydroxy-2′,5′-bis(1-methylethyl)-, (5′α)-
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• (5′α)-12′-Hydroxy-2′,5′-bis(1-methylethyl)ergotaman-3′,6′,18-trione
• 12′-Hydroxy-2′,5′-α-bis(1-methyl-ethyl)ergotaman-3′,6′,18-trion
• ERGOCORNINE >95% DOPAMINE RECEPTOR AGO
• ergocornin
• (5'alpha)-12'-Hydroxy-2',5'-bis(1-methylethyl)ergotaman-3',6',18-trione
• 12'-HYDROXY-2',5'-ALPHA-BIS(1-METHYL-ETHYL)ERGOTAMAN-3',6',18-TRIONE
• (5'α)-12'-Hydroxy-2',5'-bis(1-Methylethyl)ergotaMan-3',6',18-trione
• Ergotaman-3',6',18-trione, 12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'α)-
• 18-trione,12’-hydroxy-2’,5’-bis(1-methylethyl)-6(5’-alpha)-ergotaman-3
• NSC 407316
• ERGOCORNINE USP/EP/BP
• Ergot Cornyn
• 12'-Hydroxy-2',5'α-diisopropylergotaman-3',6',18-trione

Ergocornine

CAS: 564-36-3

Ergocornine is a naturally occurring ergot alkaloid and acts as a dopamine receptor (dopamine receptor) agonist.

Fórmula: C₃₁H₃₉N₅O₅

Forma y color: Solid

Peso molecular: 561.67

Ref: TM-TN8447

Ergocornine

Producto controlado

CAS: 564-36-3

Fórmula: C₃₁H₃₉N₅O₅

Forma y color: Neat

Peso molecular: 561.67

Ref: 04-C13201200

N-Nitroso Ergocorninine

CAS: 564-36-3

Fórmula: C₃₁H₃₈N₆O₆

Peso molecular: 590.68

Ref: 4Z-E-185002

Ergocornine

CAS: 564-36-3

Fórmula: C₃₁H₃₉N₅O₅

Peso molecular: 561.68

Ref: 4Z-E-220001

Ergocornine

Producto controlado

CAS: 564-36-3

Applications Ergocornine is a natural ergot alkaloid derived from lysergic acid. Ergocornine is a component of Ergotoxine. Ergocornine is isolated from Ergot.
References Bhat, R., et al.: Toxicol. Appl. Pharmacol., 36, 11 (1976), Komarova, E., et al.: Pharm. Chem. J., 35, 542 (2001), Krska, R., et al.: Anal. Bioanal. Chem., 391, 563 (2008), Frenich, A., et al.: Food Chem., 117, 705 (2009),

Fórmula: C₃₁H₃₉N₅O₅

Forma y color: Neat

Peso molecular: 561.67

Ref: TR-E597350

Ergocornine

Producto controlado

CAS: 564-36-3

Ergocornine is an ergoline alkaloid, which is a naturally occurring compound found in ergot fungi, specifically Claviceps species. These fungi predominantly infect cereal grains such as rye, leading to the production of a variety of ergot alkaloids. Ergocornine acts mainly by interacting with adrenergic receptors, displaying affinity for both alpha-adrenergic and serotonin receptor subtypes. This interaction results in vasoconstrictive and neuromodulatory effects, primarily impacting vascular and smooth muscle tissues.Ergocornine and related alkaloids have been studied extensively for their pharmacological properties. They are of particular interest due to their potential applications in treating conditions such as migraines, where the vasoconstrictive properties can mitigate the symptoms. Additionally, their effects on smooth muscles make them candidates for research in uterine contraction regulation during labor. However, due to the potent nature of these compounds and potential for toxicity, their clinical applications require careful consideration of dosage and delivery systems. Scientists continue to explore ergocornine's pharmacodynamics to better understand its therapeutic potential and safety profile.

Fórmula: C₃₁H₃₉N₅O₅

Pureza: Min. 95%

Peso molecular: 561.67 g/mol

Ref: 3D-FE30655