CAS 56592-32-6

Efrotomicina

Descripción:

Efrotomicina, con el número CAS 56592-32-6, es un antibiótico que pertenece a la clase de los macrólidos. Se utiliza principalmente por sus propiedades antibacterianas, particularmente contra bacterias Gram-positivas. La sustancia exhibe un mecanismo de acción que implica la inhibición de la síntesis de proteínas bacterianas al unirse a la subunidad ribosomal 50S, impidiendo así el crecimiento y la reproducción de las bacterias. Efrotomicina se caracteriza por su espectro de actividad relativamente amplio, lo que lo hace efectivo en el tratamiento de diversas infecciones. Se administra típicamente por inyección y es conocido por sus propiedades farmacocinéticas, que incluyen una buena penetración en los tejidos y una vida media moderada. El compuesto también está sujeto a procesos metabólicos en el hígado, y su excreción ocurre principalmente a través de la bilis. Al igual que con muchos antibióticos, el potencial de desarrollo de resistencia es una preocupación, lo que requiere un uso cuidadoso en entornos clínicos. En general, Efrotomicina representa una opción valiosa en el arsenal de agentes antimicrobianos, particularmente en el tratamiento de infecciones bacterianas específicas.

Fórmula: C₅₉H₈₈N₂O₂₀

InChI: InChI=1S/C59H88N2O20/c1-15-17-19-27-39-58(8,9)53(80-56-45(67)50(74-13)49(35(7)76-56)79-57-51(75-14)44(66)48(73-12)34(6)77-57)52(68)59(71,81-39)36(16-2)54(69)60-29-23-22-25-32(4)46(72-11)33(5)47-43(65)42(64)38(78-47)26-21-18-20-24-31(3)41(63)40-37(62)28-30-61(10)55(40)70/h15,17-28,30,33-36,38-39,42-53,56-57,62,64-68,71H,16,29H2,1-14H3,(H,60,69)/b17-15-,20-18+,23-22+,26-21+,27-19+,31-24+,32-25+/t33-,34+,35-,36-,38-,39+,42+,43+,44-,45-,46-,47+,48+,49-,50+,51-,52-,53+,56+,57+,59-/m1/s1

Clave InChI: InChIKey=ASOJLQIBBYOFDE-SBHXXGSWSA-N

SMILES: [C@H](C(NC/C=C/C=C(/[C@H]([C@@H](C)[C@@]1(O[C@H](/C=C/C=C/C=C(/C(=O)C=2C(=O)N(C)C=CC2O)\C)[C@H](O)[C@@H]1O)[H])OC)\C)=O)(CC)[C@]3(O)[C@H](O)[C@H](O[C@H]4[C@H](O)[C@H](OC)[C@H](O[C@H]5[C@H](OC)[C@H](O)[C@@H](OC)[C@H](C)O5)[C@@H](C)O4)C(C)(C)[C@H](/C=C/C=C\C)O3

Sinónimos:

• (alphaS,2R,3R,4R,6S)-4-((6-Deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha-L-mannopyranosyl)-3-O-methyl-beta-D-allopyranosyl)oxy)-N-((2E,4E,6S,7R)-7-((2S,3S,4R,5R)-5-((1E,3E,5E)-6-(1,2-dihydro-4-hydroxy-1-methyl-2-oxonicotinoyl)-1,3,5-heptatrienyl)tetrahydro-3,4-dihydroxy-2-furyl)-6-methoxy-5-methyl-2,4-octadienyl)-alpha-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-((1E,3Z)-1,3-pentadienyl)-2H-pyran-2-acetamide
• (αS,2R,3R,4R,6S)-4-[[6-Deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)-3-O-methyl-β-<smallcap>D</span>-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrien-1-yl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadien-1-yl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-2H-pyran-2-acetamide
• 2H-Pyran-2-acetamide, 4-[[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)-3-O-methyl-β-<smallcap>D</span>-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrien-1-yl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadien-1-yl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-, (αS,2R,3R,4R,6S)-
• 2H-Pyran-2-acetamide, 4-[[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)-3-O-methyl-β-<smallcap>D</span>-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadienyl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-1,3-pentadienyl]-, (αS,2R,3R,4R,6S)-
• Antibiotic FR 02A
• Brn 5230192
• Efrotomicina
• Efrotomicina [Spanish]
• Efrotomycin A₁
• Efrotomycin [USAN:INN:BAN]
• Efrotomycine
• Efrotomycine [French]
• Fr 02A
• Mk-621
• Mocimycin, 31-O-(6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha-L-mannopyranosyl)-3-O-methyl-beta-D-allopyranosyl)-1-methyl-
• Mocimycin, 31-O-[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)-3-O-methyl-β-<smallcap>D</span>-allopyranosyl]-1-methyl-
• Producil
• Unii-5Bpj82Q45X
• (αS,2R,3R,4R,6S)-4-[[6-Deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-β-D-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrien-1-yl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadien-1-yl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-2H-pyran-2-acetamide
• 2H-Pyran-2-acetamide, 4-[[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-β-D-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadienyl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-1,3-pentadienyl]-, (αS,2R,3R,4R,6S)-
• 2H-Pyran-2-acetamide, 4-[[6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-β-D-allopyranosyl]oxy]-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrien-1-yl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadien-1-yl]-α-ethyltetrahydro-2,3-dihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-, (αS,2R,3R,4R,6S)-

Efrotomycin

CAS: 56592-32-6

Efrotomycin: an oral antibiotic from Streptomyces Lactamdurans; minimal effect on Salmonella in pigs.

Fórmula: C₅₉H₈₈N₂O₂₀

Forma y color: Solid

Peso molecular: 1145.33

Ref: TM-T73910