CAS 571190-30-2
:Palbociclib
Descripción:
Palbociclib es un medicamento oral clasificado como un inhibidor selectivo de las quinasas dependientes de ciclinas 4 y 6 (CDK4/6), utilizado principalmente en el tratamiento del cáncer de mama positivo para receptores hormonales y negativo para el receptor 2 del factor de crecimiento epidérmico humano. Su fórmula química es C24H29N5O2, y presenta una estructura compleja que incluye un anillo de piridazina, que es crucial para su actividad biológica. Palbociclib actúa interrumpiendo el ciclo celular, inhibiendo específicamente la transición de la fase G1 a la fase S, evitando así la proliferación de células cancerosas. La sustancia se administra típicamente en combinación con inhibidores de la aromatasa o antagonistas del receptor de estrógenos para mejorar la eficacia terapéutica. Palbociclib se caracteriza por su solubilidad moderada en disolventes orgánicos y su relativamente baja solubilidad en agua, lo que puede influir en su biodisponibilidad. Su farmacocinética indica un metabolismo de primer paso significativo, principalmente por el hígado, y tiene una vida media que apoya la dosificación una vez al día. Al igual que con muchas terapias dirigidas, es esencial monitorear los efectos secundarios como la neutropenia durante el tratamiento.
Fórmula:C24H29N7O2
InChI:InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
Clave InChI:InChIKey=AHJRHEGDXFFMBM-UHFFFAOYSA-N
SMILES:O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
Sinónimos:- 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
- 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
- Ibrance
- Otava-Bb 1115529
- Palbociclib
- Palbociclib base
- Palbocyclib
- Pd 332991
- Pd 991
- Pd-0332991
- Pd0332991
- Ver más sinónimos
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Encontrado 16 productos.
Palbociclib
CAS:Fórmula:C24H29N7O2Pureza:>97.0%(T)(HPLC)Forma y color:White to Yellow to Yellow green powder to crystalPeso molecular:447.54Palbociclib
CAS:Fórmula:C24H29N7O2Pureza:(TLC) ≥ 98.0%Forma y color:Yellow powderPeso molecular:447.53Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Fórmula:C24H29N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:447.53Palbociclib Sulfate Sodium Salt
CAS:Producto controlado<p>Applications Palbociclib Sulfate is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Fórmula:C24H28N7NaO5SForma y color:NeatPeso molecular:549.58Palbociclib-d4
CAS:Producto controlado<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Fórmula:C24H25D4N7O2Forma y color:Light YellowPeso molecular:451.56Palbociclib - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C24H29N7O2Pureza:Min. 95%Forma y color:PowderPeso molecular:447.53 g/molPalbociclib
CAS:<p>Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.</p>Fórmula:C24H29N7O2Pureza:Min. 95%Forma y color:PowderPeso molecular:447.53 g/molPalbociclib-d4 Hydrochloride
CAS:Producto controlado<p>Applications Palbociclib-d4 Hydrochloride is an intermediate in synthesizing Palbociclib-d4 (P139901), an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Fórmula:C25H27D4N7O2·HClForma y color:NeatPeso molecular:465.58 + (36.46)Palbociclib N-β-D-Glucuronide Sodium Salt (Technical Grade, ~65%)
CAS:Producto controlado<p>Applications Palbociclib N-β-D-Glucuronide is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Fórmula:C30H36N7NaO8Pureza:~65%Forma y color:NeatPeso molecular:645.64Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Fórmula:C24H29N7O2Forma y color:NeatPeso molecular:447.536-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
CAS:Fórmula:C24H29N7O2Forma y color:SolidPeso molecular:447.5328
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