CAS 57808-65-8
:Closantel
Descripción:
Closantel es un agente antihelmíntico utilizado principalmente en medicina veterinaria para el tratamiento de infecciones parasitarias en ganado, particularmente en ovejas y vacas. Pertenece a la clase de compuestos conocidos como salicilanilidas y es efectivo contra una variedad de nematodos y algunos cestodos. Closantel exhibe un amplio espectro de actividad, particularmente contra lombrices intestinales y lombrices pulmonares. El compuesto se caracteriza por su naturaleza lipofílica, que mejora su absorción y distribución en el cuerpo. Actúa interrumpiendo el metabolismo energético de los parásitos, lo que lleva a su parálisis y eventual muerte. Closantel se administra típicamente por vía oral o mediante inyección, y su farmacocinética permite una eficacia prolongada, lo que lo hace adecuado para su uso en la gestión del ganado. Los perfiles de seguridad indican que tiene una baja toxicidad para los mamíferos, pero se debe tener cuidado con su uso en animales productores de alimentos, ya que son necesarios períodos de retiro para asegurar que los residuos no entren en la cadena alimentaria. En general, Closantel es una herramienta valiosa en la parasitología veterinaria, contribuyendo a la salud y productividad del ganado.
Fórmula:C22H14Cl2I2N2O2
InChI:InChI=1/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
Clave InChI:InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N
SMILES:C(C#N)(C1=C(Cl)C=C(NC(=O)C2=C(O)C(I)=CC(I)=C2)C(C)=C1)C3=CC=C(Cl)C=C3
Sinónimos:- 5'-Chloro-4'-(4-Chloro-Alpha-Cyanobenzyl)-3,5-Diiodo-2'-Methylsalicylanilide
- 5-Diiodo-Y-
- Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-
- Benzamide,N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydrox
- Closantel Base
- Clozantin
- Faskoverm
- Iodobenzamide
- N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydroxy-3,5-Di
- N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
- NSC 335306
- S 4105
- Seponver
- Zycloz
- Closantel
- CLOSANTEL(PATENT)
- N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide
- n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE
- 5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide
- Closantelfreebase
- N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)
- N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE
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Encontrado 13 productos.
Closantel
CAS:Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.Fórmula:C22H14Cl2I2N2O2Pureza:98.52% - 99.86%Forma y color:White To Yellowish PowderPeso molecular:663.07N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-Diiodobenzamide
CAS:N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-DiiodobenzamidePureza:99+%Peso molecular:663.07g/molClosantel 100 µg/mL in Acetonitrile
CAS:Fórmula:C22H14Cl2I2N2O2Forma y color:Single SolutionPeso molecular:663.07Closantel 1000 µg/mL in Acetonitrile
CAS:Producto controladoFórmula:C22H14Cl2I2N2O2Forma y color:Single SolutionPeso molecular:663.07Closantel
CAS:Fórmula:C22H14Cl2I2N2O2Pureza:>98.0%(HPLC)(qNMR)Forma y color:White to Light yellow powder to crystalPeso molecular:663.07Closantel
CAS:Producto controlado<p>Applications Closantel is potentially useful for studying P-glycoprotein interactions in vitro.Closantel was used in preparation of Closantel-derived bacterial two-component system inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hlasta, D., et al.: Bioorg. Med. Chem. Lett., 8, 1923 (1998);<br></p>Fórmula:C22H14Cl2I2N2O2Forma y color:NeatPeso molecular:663.07Closantel
CAS:Closantel is a drug that is used to treat worm infections. Closantel binds to the enzyme target and inhibits its function, leading to cell death. Closantel has been shown to be effective against resistant mutants in wastewater treatment, as well as in animal studies. The enzyme inhibitor activity of closantel can be measured by electrochemical impedance spectroscopy (EIS) and fluorescence detection. It also shows protein binding properties with anthelmintic drugs. This drug has been shown to have no significant toxicity for humans at therapeutic doses, and is not detectable in human serum or urine samples when taken orally. It has been detected in human serum after intravenous administration, but this route of administration should be avoided due to the risk of serious adverse effects.Fórmula:C22H14Cl2I2N2O2Pureza:Min. 95%Forma y color:PowderPeso molecular:663.07 g/molN-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
CAS:Pureza:98%Peso molecular:663.07
