CAS 58-00-4

(-)-Apomorfina

Descripción:

(-)-Apomorfina es un compuesto químico clasificado como un alcaloide y se deriva de la morfina. Se conoce por sus propiedades de agonista de la dopamina, afectando principalmente al sistema nervioso central. El compuesto aparece como un polvo cristalino blanco a blanco sucio y es soluble en agua, alcohol y cloroformo, lo que lo hace versátil para diversas aplicaciones. Su fórmula molecular es C17H17N, y tiene una estructura tridimensional compleja que le permite interactuar con los receptores de dopamina, particularmente los subtipos D1 y D2. (-)-Apomorfina se utiliza principalmente en el campo médico para el tratamiento de la enfermedad de Parkinson y la disfunción eréctil, ya que puede estimular la liberación de dopamina y mejorar la función motora. Sin embargo, también puede tener efectos secundarios, incluyendo náuseas e hipotensión. Debido a sus efectos farmacológicos, (-)-Apomorfina está sujeto a regulación en muchos países. Su estereoequilibrio es significativo, ya que el enantiómero (-) es la forma biológicamente activa, destacando la importancia de la quiralidad en la química medicinal.

Fórmula: C₁₇H₁₇NO₂

InChI: InChI=1/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/p+1/t13-/m1/s1

Clave InChI: InChIKey=VMWNQDUVQKEIOC-CYBMUJFWSA-N

SMILES: CN1[C@]2(C=3C(C=4C(C2)=CC=C(O)C4O)=CC=CC3CC1)[H]

Sinónimos:

• (-)-10,11-Dihydroxyaporphine
• (6aR)-10,11-dihydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium
• (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo(de,g)chinolin-10,11-diol
• (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
• 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)-
• 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)- (9CI)
• 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-
• 6a-beta-Aporphine-10,11-diol
• 6abeta-Aporphine-10,11-diol
• 6aβ-Aporphine-10,11-diol
• Apokyn
• Apomorfin
• Apomorfina
• Apomorphin
• Hsdb 3289
• Ixense
• L-Apomorphine
• R-(-)-Apomorphine
• Unii-N21Far7B4S
• Apomorphine
• APOMORPHINE, NASAL, BRITANNIA,4H-DIBENZO[DE-G]QUINOLINE-10,11-DIOL, 5,6,6A,7-TETRAHYDRO-6-METHYL, (R)-
• (6aS)-5,6,6aα,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
• (6AR)-6-METHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL OR APOMORPHINE

(R)-Apomorphine-d5 Hydrochloride (Major)

Producto controlado

CAS: 314-19-2, 58-00-4, 76787-62-7

Fórmula: C₁₇H₁₂D₅NO₂•HCl

Forma y color: Neat

Peso molecular: 272.363646

Ref: TR-A727503

(R)​-​(-​)​-​Apomorphine

Producto controlado

CAS: 58-00-4

Applications (R)​-​(-​)​-​Apomorphine is a dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970); Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991)

Fórmula: C₁₇H₁₇NO₂

Forma y color: Green

Peso molecular: 267.32

Ref: TR-A727495

Apomorphine

Producto controlado

CAS: 58-00-4

Apomorphine is a chemical compound that can be used as an analytical tool to study the effects of dopamine on physiological processes, and pharmacological agents on pharmacokinetics. It is also used in the treatment of Parkinson's disease. Apomorphine is a potent agonist at dopaminergic receptors in the central nervous system, and has been shown to increase locomotor activity and improve the rotarod test performance in rats. Apomorphine binds to dopamine receptors in the brain, replacing dopamine as it becomes depleted. The drug also blocks reuptake of dopamine by neurons and increases release of dopamine from nerve terminals. Apomorphine has a short half-life of about 2 hours, but may have potential for long-term treatment because its effects can last up to 24 hours.

Fórmula: C₁₇H₁₇NO₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 267.32 g/mol

Ref: 3D-FA44559

Apomorphine-8-Sulfonic Acid

Producto controlado

CAS: 58-00-4

Applications Apomorphine-8-Sulfonic Acid is an impurity of (R)​-​(-​)​-​Apomorphine(A727495), (R)​-​(-​)​-​Apomorphine is a dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970); Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991)

Fórmula: C₁₇H₁₇NO₅S

Forma y color: Neat

Peso molecular: 347.386

Ref: TR-A737495