CAS 58-05-9

Leucovorina

Descripción:

Leucovorina, también conocido como ácido folínico, es una forma reducida del ácido fólico que desempeña un papel crucial en varios procesos bioquímicos, particularmente en la síntesis de ácidos nucleicos y aminoácidos. Se utiliza comúnmente en entornos médicos como agente de rescate tras la terapia con metotrexato, ya que puede ayudar a mitigar los efectos tóxicos del fármaco en las células sanas al proporcionar una fuente de folato activo. Leucovorina es un polvo cristalino blanco a blanco amarillento que es soluble en agua, lo que lo hace adecuado para la administración intravenosa u oral. Su estructura química incluye un anillo de pteridina, un grupo ácido para-aminobenzoico y un residuo de ácido glutámico, que contribuyen a su actividad biológica. Leucovorina también se utiliza en combinación con fluorouracilo para mejorar su eficacia en el tratamiento de ciertos cánceres. Debido a su papel en el metabolismo celular, es esencial para la correcta síntesis y reparación del ADN, lo que lo hace vital en contextos terapéuticos y fisiológicos.

Fórmula: C₂₀H₂₃N₇O₇

InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

Clave InChI: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O

Sinónimos:

• (6R,S)-5-Formyltetrahydrofolate
• 10-Formyl-7,8-dihydrofolic acid
• 5-Formyl-5,6,7,8-tetrahydrofolic acid
• 5-Formyltetrahydrofolic Acid
• 5-Formyltetrahydrofolsaure
• 5-Formyltetrahydropteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Acide 5-Formyltetrahydrofolique
• Acido 5-Formiltetrahidrofolico
• CF
• Folinic acid
• Folinic acid-SF
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• Kunyrin
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Leucal
• Leucoverin
• Leucovorin
• Levoleucovorin
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N5-Formyl-5,6,7,8-tetrahydrofolic acid
• N5-Formyltetrahydrofolic acid
• N⁵-Formyl-5,6,7,8-tetrahydrofolic acid
• N⁵-Formyl-THF
• N⁵-Formyltetrahydrofolic acid
• Welcovorin
• l-Leucovorin
• N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• 5-formyltetrahydrofolate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• N5-formyl-5,6,7,8-tetrahydrofolate
• N5-formyl-tetrahydrofolate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: >98.0%(T)(HPLC)

Forma y color: Light orange to Yellow to Green powder to crystaline

Peso molecular: 511.51

Ref: 3B-C2235

(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

CAS: 58-05-9

Fórmula: C₂₀H₂₃N₇O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 473.4393

Ref: IN-DA003A0Z

Folinic acid

CAS: 58-05-9

Folinic acid

Pureza: ≥98%

Peso molecular: 473.44g/mol

Ref: 54-BUP11034

Folinic Acid

CAS: 58-05-9

Folinic Acid

Pureza: 98%

Peso molecular: 473.44g/mol

Ref: 54-OR1027762

Folinic Acid

CAS: 58-05-9

Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.
References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)

Fórmula: C₂₀H₂₃N₇O₇

Forma y color: Neat

Peso molecular: 473.45

Ref: TR-F680340

Folinic acid

CAS: 58-05-9

Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-

Fórmula: C₂₀H₂₃N₇O₇

Pureza: 99.76%

Forma y color: Crystals From Water With 3 Mol Of Water Of Crystallization Solid

Peso molecular: 473.44

Ref: TM-T24403

Folinic acid

CAS: 58-05-9

Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.

Fórmula: C₂₀H₂₃N₇O₇

Pureza: (%) Min. 97%

Forma y color: White Powder

Peso molecular: 473.44 g/mol

Ref: 3D-FF156776