CAS 58066-85-6

Miltefosina

Descripción:

Miltefosina es un compuesto orgánico reconocido principalmente por su uso como medicamento antiparasitario, particularmente en el tratamiento de la leishmaniasis. Se clasifica como un derivado de fosfolípido y se caracteriza por su naturaleza anfifílica, que le permite interactuar con entornos tanto hidrofílicos como hidrofóbicos. Miltefosina tiene una fórmula molecular que incluye carbono, hidrógeno, nitrógeno, oxígeno y fósforo, lo que contribuye a su estructura compleja. La sustancia se administra típicamente por vía oral y es notable por su capacidad para interrumpir las membranas celulares e inhibir el crecimiento de parásitos. Su mecanismo de acción implica la interferencia con el metabolismo de lípidos y la apoptosis en los organismos objetivo. Miltefosina también se asocia con una variedad de efectos secundarios, incluidos trastornos gastrointestinales y posibles efectos teratogénicos, lo que requiere precaución en su uso, particularmente en individuos embarazados. Además, se ha estudiado para aplicaciones potenciales más allá de la leishmaniasis, incluidas sus propiedades antivirales. En general, Miltefosina representa un avance significativo en el manejo farmacológico de ciertas infecciones parasitarias.

Fórmula: C₂₁H₄₆NO₄P

InChI: InChI=1/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3

Clave InChI: InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N

SMILES: O(P(OCC[N+](C)(C)C)(=O)[O-])CCCCCCCCCCCCCCCC

Sinónimos:

• 1-n-Hexadecylphosphorylcholine
• 2-(((Hexadecyloxy)Hydroxyphosphinyl)Oxy)-N,N,N-Trimethyl-Ethanaminiuhydrox
• 2-(((Hexadecyloxy)Hydroxyphosphinyl)Oxy)-N,N,N-Trimethylethanaminiumhydroxid
• Choline Hexadecyl Phosphate
• Choline phosphate, hexadecyl ester, hydroxide, inner salt
• Cholinephosphate,Hexadecylester,Hydroxide,Innersalt
• D 18506
• Ethanaminium, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
• Fos-choline 16
• Hexadecyl 2-(Trimethylammonio)Ethyl Phosphate
• Hexadecylphosphorylcholine
• Impavido
• Miltefos
• Miltefosine
• Miltex
• NSC 605583
• n-Hexadecylphosphocholine
• n-Hexadecylphosphorylcholine
• Hexadecylphosphocholine
• HPC
• C16 : O
• HEXADECYL PHOSPHORYLCHOLINE
• Miltefosin
• 1-HEXADECYLPHOSPHOCHOLINE
• mil
• d18506
• HEPC
• 1-HEXADECYLPHOSPHORYLCHOLINE
• C16:0
• Hexadecyl 2-(trimethylamino)ethyl phosphate
• N-HEXADECYL-PHOSPHOCHOLINE

Miltefosine

CAS: 58066-85-6

Fórmula: C₂₁H₄₆NO₄P

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 407.58

Ref: 3B-M2445

Miltefosine

CAS: 58066-85-6

Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.

Fórmula: C₂₁H₄₆NO₄P

Pureza: 98% - 99.94%

Forma y color: White To Off-White Powder

Peso molecular: 407.57

Ref: TM-T0033

Miltefosine

CAS: 58066-85-6

Fórmula: C₂₁H₄₆NO₄P

Forma y color: White To Off-White Solid

Peso molecular: 407.58

Ref: 4Z-M-791

Miltefosine

CAS: 58066-85-6

Miltefosine

Pureza: ≥98%

Peso molecular: 407.57g/mol

Ref: 54-BUP15995

Miltefosine

CAS: 58066-85-6

Fórmula: C₂₁H₄₆NO₄P

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: White or almost white powder

Peso molecular: 407.57

Ref: 7W-GL2721

Hexadecylphosphocholine

CAS: 58066-85-6

Hexadecylphosphocholine

Fórmula: H₂

Forma y color: white powder

Peso molecular: 407.57g/mol

Ref: 54-BIB6120

Miltefosine-d9

CAS: 58066-85-6

Fórmula: C₂₁H₃₇D₉NO₄P

Peso molecular: 416.63

Ref: 4Z-M-792

Miltefosine

Producto controlado

CAS: 58066-85-6

Applications A phospholipid drug with antineoplastic and antiprotozoal/antifungal properties, also acts as an Akt inhibitor, and under investigation as a potential therapy against HIV infection.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chugh, P., et al al.: Retrovirology, 5, 11 (2008), Dorio, T., et al.: Antimicrob. Agents Chemother., 52, 2855 (2008),

Fórmula: C₂₁H₄₆NO₄P

Forma y color: Neat

Peso molecular: 407.57

Ref: TR-M344460

1-Hexadecylphosphorylcholine

CAS: 58066-85-6

Treatment for leishmaniasis

Fórmula: C₂₁H₄₆NO₄P

Pureza: Min 98%

Forma y color: White Powder

Peso molecular: 407.57 g/mol

Ref: 3D-FH10347

Hexadecylphosphocholine

CAS: 58066-85-6

Hexadecylphosphocholine, better known as miltefosine, belongs to the group of phospholipids. The long alkyl chain and a polar group of a molecule proved to be essential for antitumor activity, especially to cure breast cancer cells. The apoptotic process takes place in the plasma membrane, where molecules are inserted and then influence signaling pathways. Moreover, during preclinical studies hexadecylphosphocholine (He-PC) found to be highly effective in inhibiting the growth of chemically induced rat mammary carcinomas, and even a high percentage of the tumors regressed completely. The He-PC has many more applications such as antifungal agent, antiprotozoal drug, protein kinase inhibitor or immunomodulator. Even though miltefosine was originally developed in the 1980s as an anti-cancer agent, new studies have demonstrated activity against Leishmania parasites and neoplastic cells, and due to broad spectrum of antimicrobial effects, it is recommended as a first line treatment for free-living amebae infections.

Fórmula: C₂₁H₄₆NO₄P

Peso molecular: 407.57 g/mol

Ref: 3D-M-7200

1-Hexadecylphosphocholine

CAS: 58066-85-6

M01856 - 1-Hexadecylphosphocholine

Fórmula: C₂₁H₄₆NO₄P

Pureza: >99%

Forma y color: Solid

Peso molecular: 407.576

Ref: 10-M01856

Miltefosine-d9

Producto controlado

CAS: 58066-85-6

Fórmula: C₂₁H₃₇D₉NO₄P

Forma y color: Neat

Peso molecular: 662.796

Ref: TR-M344463