CAS 58479-68-8

Platicodina D

Descripción:

Platicodina D es un saponina triterpenoide derivada principalmente de la raíz de Platycodon grandiflorus, una planta comúnmente utilizada en la medicina tradicional, especialmente en Asia Oriental. Se conoce por sus diversas actividades biológicas, incluyendo propiedades antiinflamatorias, inmunomoduladoras y anticancerígenas. La estructura química de Platicodina D presenta un esqueleto tipo dammarano, que contribuye a su bioactividad. Se caracteriza típicamente por su solubilidad en agua y disolventes orgánicos, aunque su solubilidad puede variar dependiendo del disolvente utilizado. Platicodina D ha sido objeto de numerosos estudios que investigan sus efectos farmacológicos, incluyendo su potencial para mejorar la salud respiratoria y su papel en la modulación de respuestas inmunitarias. Además, exhibe efectos citotóxicos contra ciertas líneas celulares cancerosas, lo que lo convierte en un compuesto de interés en la investigación del cáncer. Al igual que muchos productos naturales, los procesos de extracción y purificación pueden influir en su eficacia y biodisponibilidad, destacando la importancia de técnicas analíticas adecuadas en el estudio de sus propiedades y aplicaciones.

Fórmula: C₅₇H₉₂O₂₈

InChI: InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1

Clave InChI: InChIKey=CYBWUNOAQPMRBA-NDTOZIJESA-N

SMILES: C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O[C@H]4[C@H](O)[C@](CO)(O)CO4)[C@H](O)CO3)[C@H](C)O2)[C@@H](O)[C@@H](O)CO1)(=O)[C@]56[C@](C=7[C@@](C)(C[C@H]5O)[C@@]8(C)[C@](CC7)([C@]9(C)[C@@](CC8)(C(CO)(CO)[C@@H](O[C@@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%10O)[C@@H](O)C9)[H])[H])(CC(C)(C)CC6)[H]

Sinónimos:

• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• 3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]-beta-D-xylopyranosyl-(1->4)-6-deoxy-alpha-L-mannopyranosyl-(1->2)-1-O-[(2beta,3beta,16alpha)-3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-28-oxoolean-12-en-28-yl]-alpha-L-arabinopyranose
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• Olean-12-en-28-oic acid, 3-(β-<span class="text-smallcaps">D</smallcap>-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-<smallcap>D</smallcap>-apio-β-<smallcap>D</smallcap>-furanosyl-(1→3)-O-β-<smallcap>D</smallcap>-xylopyranosyl-(1→4)-O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-α-<smallcap>L</span>-arabinopyranosyl ester, (2β,3β,16α)-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,16α)-

PLATYCODIN D CRS

CAS: 58479-68-8

PLATYCODIN D CRS

Ref: 41-Y0001946

Platycodin D

CAS: 58479-68-8

Fórmula: C₅₇H₉₂O₂₈

Pureza: 95%

Forma y color: Solid

Peso molecular: 1225.3236

Ref: IN-DA00EBH4

Platycodin D

CAS: 58479-68-8

Fórmula: C₅₇H₉₂O₂₈

Peso molecular: 1225.34

Ref: 7W-GY7597

Platycodin D

CAS: 58479-68-8

Platycodon D (PD) and D3 (PD3) isolated from Platycodon grandiflorum has been previously reported to show anti-inflammatory activities in rats, PD may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, suggest a dichotomous regulation of these important proinflammatory mediators by PD and PD3.

Fórmula: C₅₇H₉₂O₂₈

Pureza: 95%~99%

Forma y color: White powder

Peso molecular: 1225.34

Ref: BP-BP1111

Platycodin D

CAS: 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.

Fórmula: C₅₇H₉₂O₂₈

Pureza: 99.2% - 99.65%

Forma y color: Solid

Peso molecular: 1225.32

Ref: TM-T3889

Platycodin d

CAS: 58479-68-8

Natural glycoside

Fórmula: C₅₇H₉₂O₂₈

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 1225.34

Ref: 5G-80518

Platycodin D

Producto controlado

CAS: 58479-68-8

Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.
References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);

Fórmula: C₅₇H₉₂O₂₈

Forma y color: Neat

Peso molecular: 1225.32

Ref: TR-P578200

Platycodin D

CAS: 58479-68-8

Platycodin D is a natural product that belongs to the class of platycodins. It is a polysaccharide with anti-inflammatory properties and has been shown to suppress inflammation, oxidative injury, and improve mitochondrial function in vitro. Platycodin D also inhibits Toll-like receptor (TLR) signaling pathways that are activated by extracellular bacteria or their products. Platycodin D binds to dsDNA and inhibits DNA binding proteins such as dextran sulfate. This interaction prevents the induction of the inflammatory response. The effects of platycodin D have been demonstrated in an experimental model involving mice. In vivo studies on rats have shown that this compound has an anti-inflammatory effect and reduces oxidative injury.

Fórmula: C₅₇H₉₂O₂₈

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 1,225.32 g/mol

Ref: 3D-FP73789