CAS 58626-38-3

m-Maleimidobenzoyl-N-hidroxisuccinimida

Descripción:

m-Maleimidobenzoyl-N-hidroxisuccinimida (CAS 58626-38-3) es un compuesto químico comúnmente utilizado en aplicaciones de bioconjugación y etiquetado de proteínas. Presenta un grupo maleimida, que es altamente reactivo hacia grupos tiol, permitiendo la formación de enlaces tioéter estables con residuos de cisteína en proteínas. La presencia del éster de N-hidroxysuccinimida (NHS) aumenta su reactividad con grupos amina, facilitando la conjugación de biomoléculas como péptidos, proteínas y anticuerpos. Este compuesto es típicamente un sólido a temperatura ambiente y es soluble en disolventes orgánicos como dimetilsulfóxido (DMSO) y dimetilformamida (DMF). Su reactividad y especificidad lo hacen valioso en el desarrollo de sistemas de entrega de medicamentos dirigidos, ensayos diagnósticos y la creación de bioconjugados para fines de investigación. Se debe tener cuidado al manipular este compuesto, ya que puede ser sensible a la humedad y debe almacenarse en condiciones adecuadas para mantener su estabilidad y reactividad.

Fórmula: C₁₅H₁₀N₂O₆

InChI: InChI=1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2

Clave InChI: InChIKey=LLXVXPPXELIDGQ-UHFFFAOYSA-N

SMILES: O=C1N(C2=CC(C(ON3C(=O)CCC3=O)=O)=CC=C2)C(=O)C=C1

Sinónimos:

• (2,5-Dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate
• 1-(3-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1H-pyrrole-2,5-dione
• 1H-Pyrrole-2,5-dione, 1-[3-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]phenyl]-
• 3-Maleimidobenzoic acid N-hydroxysuccinimide ester
• 3-Maleimidobenzoyl N-hydroxysuccinimide
• Benzoic acid, 3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,5-dioxo-1-pyrrolidinyl ester
• N-(3-Maleimidobenzoyloxy)succinamide
• N-(m-Maleimidobenzoyloxy)succinamide
• N-(m-Maleimidobenzoyloxy)succinimide
• NSC 294786
• m-Maleimidobenzoic acid N-hydroxysuccinimide ester
• m-Maleimidobenzoyl N-hydroxysuccinimide ester
• m-Maleimidobenzoyl-N-hydroxysuccinimide

N-Succinimidyl 3-Maleimidobenzoate [Cross-linking Reagent]

CAS: 58626-38-3

Fórmula: C₁₅H₁₀N₂O₆

Pureza: >98.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 314.25

Ref: 3B-S0398

N-Succinimidyl 3-maleimidobenzoate, 95%

CAS: 58626-38-3

A heterobifunctional coupling reagent useful for forming enzyme immunoconjugates

Fórmula: C₁₅H₁₀N₂O₆

Pureza: 95%

Peso molecular: 314.26

Ref: 02-J61410

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

CAS: 58626-38-3

Fórmula: C₁₅H₁₀N₂O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 314.2497

Ref: IN-DA0033QL

MBS Crosslinker

CAS: 58626-38-3

MBS is a non-cleavable, water-insoluble protein crosslinker; SMPB is its extended form. SATA modifies proteins/peptides with sulfhydryl for MBS use.

Fórmula: C₁₅H₁₀N₂O₆

Forma y color: Crystalline

Peso molecular: 314.25

Ref: TM-T19941

MBS Crosslinker

CAS: 58626-38-3

MBS Crosslinker

Peso molecular: 314.25g/mol

Ref: 54-BUP14045

3-Maleimidobenzoyl-N-hydroxysuccinimide ester

CAS: 58626-38-3

3-Maleimidobenzoyl-N-hydroxysuccinimide ester

Fórmula: C₁₅H₁₀N₂O₆

Pureza: 98%

Forma y color: white solid

Peso molecular: 314.25g/mol

Ref: 54-BICL202

3-N-Maleimidobenzoic acid N-succinimidyl ester

CAS: 58626-38-3

3-N-Maleimidobenzoic acid N-succinimidyl ester is a potent inhibitor of the enzyme aromatase, the enzyme responsible for the conversion of androgens to estrogens. 3-N-Maleimidobenzoic acid N-succinimidyl ester binds covalently to the active site of aromatase, thereby inhibiting its activity. This drug also has been shown to be effective in reducing the production of blood group antigens in rats. 3-N-Maleimidobenzoic acid N-succinimidyl ester binds to homologous proteins, such as albumins and hemoglobins, and inhibits their function. The drug can be used as an immunogen to produce antibodies against these proteins. Toxicity studies have been conducted with this drug in rats and mice with no observed adverse effects at doses up to 500 mg/kg.

Fórmula: C₁₅H₁₀N₂O₆

Pureza: Min. 97 Area-%

Forma y color: Powder

Peso molecular: 314.25 g/mol

Ref: 3D-FM24983

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

CAS: 58626-38-3

Fórmula: C₁₅H₁₀N₂O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 314.253

Ref: 10-F492503