CAS 58970-76-6

Bestatina

Descripción:

Bestatina es un compuesto químico conocido por su papel como un potente inhibidor de aminopeptidasas, particularmente de la aminopeptidasa N. Se clasifica como un dipeptido, compuesto por los aminoácidos L-fenilalanina y L-leucina. Bestatina exhibe una estructura única que le permite unirse eficazmente al sitio activo de las aminopeptidasas, inhibiendo así su actividad enzimática. Esta inhibición tiene implicaciones en varios procesos biológicos, incluyendo la modulación de la respuesta inmune y el tratamiento del cáncer. Bestatina también se destaca por su posible uso en la mejora de la eficacia de ciertos agentes quimioterapéuticos. El compuesto se administra típicamente en un contexto farmacéutico, y su perfil de seguridad ha sido evaluado en estudios clínicos. Al igual que muchos compuestos bioactivos, la farmacocinética y el metabolismo de Bestatina son importantes para entender sus aplicaciones terapéuticas y posibles efectos secundarios. En general, Bestatina representa un interés significativo en la química medicinal debido a sus propiedades de inhibición enzimática y beneficios terapéuticos potenciales.

Fórmula: C₁₆H₂₄N₂O₄

InChI: InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1

Clave InChI: InChIKey=VGGGPCQERPFHOB-RDBSUJKOSA-N

SMILES: C([C@H]([C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)O)N)C1=CC=CC=C1

Sinónimos:

• <span class="text-smallcaps">L</span>-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
• <span class="text-smallcaps">L</span>-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-
• Bestain
• Bestatin
• N-(3-amino-2-hydroxy-4-phenylbutanoyl)leucine
• N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-<span class="text-smallcaps">L</span>-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-D-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine
• NSC 265489
• Nk 421
• L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
• N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine

Bestatin

CAS: 58970-76-6

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in mul

Fórmula: C₁₆H₂₄N₂O₄

Forma y color: White to pale cream, Powder

Peso molecular: 308.38

Ref: 02-J61106

[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine

CAS: 58970-76-6

Bestatin (or ubenimex), an antibiotic of natural origin, is a specific, competitive inhibitor of many aminopeptidases, though it does not inhibit aminopeptidase A. Due to its low toxicity it has been administered to cultured cells, animals and humans. Bestatin offered by Bachem has been obtained by chemical synthesis.

Fórmula: C₁₆H₂₄N₂O₄

Pureza: 99.5%

Forma y color: White Powder

Peso molecular: 308.38

Ref: 01-4006587

(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid

CAS: 58970-76-6

Fórmula: C₁₆H₂₄N₂O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 308.3728

Ref: IN-DA00370Q

Bestatin (Ubenimex)

CAS: 58970-76-6

Fórmula: C₁₆H₂₄N₂O₄

Forma y color: White To Off-White Solid

Peso molecular: 308.38

Ref: 4Z-B-119001

Bestatin

CAS: 58970-76-6

Bestatin

Pureza: ≥98%

Peso molecular: 308.37g/mol

Ref: 54-BUP10959

N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine

CAS: 58970-76-6

Fórmula: C₁₆H₂₄N₂O₄

Pureza: ≥ 98.0%

Forma y color: White powder

Peso molecular: 308.37

Ref: 7W-GM3911

Ubenimex Hydrochloride [for Biochemical Research]

CAS: 58970-76-6, 65391-42-6

Fórmula: C₁₆H₂₄N₂O₄·HCl

Pureza: >97.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 344.84

Ref: 3B-B4000

Ubenimex

CAS: 58970-76-6

Fórmula: C₁₆H₂₄N₂O₄

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 308.38

Ref: 3B-U0111

Bestatin-d5 (Ubenimex-d5)

CAS: 58970-76-6

Fórmula: C₁₆H₁₉N₂O₄D₅

Peso molecular: 313.41

Ref: 4Z-B-119002

Bestatin free base

CAS: 58970-76-6

Bestatin free base

Fórmula: C₁₆H₂₄N₂O₄

Pureza: By hplc: >98% by area (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 308.37g/mol

Ref: 54-BIMI2138

Bestatin

CAS: 58970-76-6

Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.

Fórmula: C₁₆H₂₄N₂O₄

Pureza: 98% - 99.63%

Forma y color: White Crystalline Powder

Peso molecular: 308.37

Ref: TM-T1257

Ubenimex - Bio-X ™

CAS: 58970-76-6

Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.

Fórmula: C₁₆H₂₄N₂O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 308.37 g/mol

Ref: 3D-BU164499

Ubenimex

CAS: 58970-76-6

Aminopeptidase N (CD13) inhibitor; immunomodulator

Fórmula: C₁₆H₂₄N₂O₄

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 308.37 g/mol

Ref: 3D-FU65199

Ubenimex (Bestatin)

CAS: 58970-76-6

Ubenimex (Bestatin) is an enzyme inhibitor that belongs to the class of dpp-iv inhibitors. It is used as an antifungal agent and has been shown to be effective against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton mentagrophytes, and Microsporum canis. Ubenimex (Bestatin) inhibits the synthesis of protein by binding to the 30S ribosomal subunit and blocking the peptidyl transferase activity of the 50S ribosomal subunit. This drug also has a cytostatic effect on cancer cells in vitro.

Fórmula: C₁₆H₂₄N₂O₄

Pureza: Min. 95%

Peso molecular: 308.37 g/mol

Ref: 3D-IBS-4093-PI

Bestatin

Producto controlado

CAS: 58970-76-6

Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.
References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);

Fórmula: C₁₆H₂₄N₂O₄

Forma y color: Neat

Peso molecular: 308.37

Ref: TR-B319500

Bestatin-d7

Producto controlado

CAS: 58970-76-6

Fórmula: C₁₆D₇H₁₇N₂O₄

Forma y color: Neat

Peso molecular: 315.416

Ref: TR-B319502