CAS 59247-13-1

gangliósido GT1B del cerebro bovino

Descripción:

El gangliósido GT1b es un glicoesfingolípido complejo que se encuentra predominantemente en el tejido nervioso, particularmente en el cerebro de los mamíferos, incluidos los bovinos. Se caracteriza por su estructura, que consiste en un esqueleto de ceramida unido a una porción de carbohidrato que incluye residuos de ácido siálico. Este gangliósido desempeña un papel crucial en la señalización celular, el desarrollo neuronal y la modulación de la transmisión sináptica. Se conoce que el GT1b está involucrado en varios procesos biológicos, incluida la neuroprotección y el reconocimiento celular. Su presencia en el cerebro contribuye a la formación de balsas lipídicas, que son esenciales para el correcto funcionamiento de las proteínas de membrana. Además, los gangliósidos como el GT1b están implicados en enfermedades neurodegenerativas y se estudian por sus posibles aplicaciones terapéuticas. El número CAS 59247-13-1 identifica específicamente este compuesto, facilitando su reconocimiento en la literatura científica y bases de datos. En general, el gangliósido GT1b es significativo en neurociencia y bioquímica debido a su complejidad estructural y su importancia funcional en las interacciones celulares dentro del sistema nervioso.

Fórmula: C₈₈H₁₅₇N₅O₄₄

InChI: InChI=1/C88H157N5O44/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-56(107)92-37-51(45(101)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)124-80-66(113)65(112)70(54(42-98)127-80)129-82-69(116)77(136-87(84(120)121)35-46(102)57(89)72(132-87)61(108)49(105)38-94)71(55(43-99)128-82)130-79-60(93-44(3)100)75(63(110)52(40-96)125-79)131-81-68(115)76(64(111)53(41-97)126-81)135-86(83(118)119)34-47(103)59(91)74(134-86)67(114)78(117)137-88(85(122)123)36-48(104)58(90)73(133-88)62(109)50(106)39-95/h30,32,45-55,57-82,94-99,101-106,108-117H,4-29,31,33-43,89-91H2,1-3H3,(H,92,107)(H,93,100)(H,118,119)(H,120,121)(H,122,123)/b32-30+/t45?,46-,47-,48-,49?,50?,51?,52-,53-,54+,55-,57+,58+,59+,60-,61?,62?,63+,64+,65+,66+,67?,68-,69-,70+,71+,72+,73+,74+,75-,76+,77-,78?,79+,80+,81+,82+,86+,87+,88+/m0/s1

Sinónimos:

• Ganglioside, GT1
• GT(1)Ganglioside
• GT1b Ganglioside
• Ganglioside GT1b
• N-Acetylneuraminylgalactosyl-N-acetylgalactosaminyl -(N-acetylneuraminyl-N-acetylneuraminyl)galactosyl- glucosylceramide
• Polysialoganglioside
• Trisialoganglioside GT1b
• (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-4-[(2S,3S,4R,5R,6S)-4-[(2R,4S,5R,6R)-5-amino-6-[2-[(2R,4S,5R,6R)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-ethyl]-2-carboxy-4-hydroxy-tetrahydropyran-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-carboxylic acid

Ganglioside GT1b Mixture (sodium salt)

CAS: 59247-13-1

GT1b, a trisialoganglioside, binds neurotoxins and MCPyV VP1, inhibits IL-6, IL-10, IgG, IgM, IgA, and has C18:1/C20:1 sphingoid backbones.

Fórmula: C₉₅H₁₆₂N₅O₄₇₃Na

Forma y color: Solid

Peso molecular: 2195.27

Ref: TM-T36862

Trisialoganglioside GT1b NH4+ salt

CAS: 59247-13-1

Fórmula: Unspecified

Pureza: >98%

Forma y color: Solid

Ref: 48-56-1105

GT1b-Ganglioside

CAS: 59247-13-1

Fórmula: C₉₅H₁₆₂N₅O₄₇·3Na

Pureza: ≥ 98%

Forma y color: White to off-white powder

Peso molecular: 2159.3

Ref: 7W-GC4593

GT1b-Ganglioside sodium

CAS: 59247-13-1

GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Fórmula: C₉₅H₁₆₅N₅O₄₈·xNa

Forma y color: White Powder

Peso molecular: 2,145.33 g/mol

Ref: 3D-OG03923

GT1b-Ganglioside ammonium

CAS: 59247-13-1

GT1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Fórmula: C₉₅H₁₆₅N₅O₄₈·xNH₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 2,145.33 g/mol

Ref: 3D-OG167138

Ganglioside GT1b trisodium salt

Producto controlado

CAS: 59247-13-1

Applications Ganglioside GT1b trisodium salt (bovine brain) is a glycosphingolipid neuroprotectant.

Fórmula: C₉₅H₁₆₂N₅Na₃O₄₇

Forma y color: Neat

Peso molecular: 2195.28

Ref: TR-G235078

Ganglioside GT1b

CAS: 59247-13-1

Fórmula: C₈₈H₁₅₇N₅O₄₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 1989.1952799999976

Ref: IN-DA01CBD9