CAS 59721-29-8

Mesilato de camostat

Descripción:

Mesilato de camostat es un inhibidor sintético de la serina proteasa conocido principalmente por su papel en la inhibición de la actividad de la enzima tripsina. Se caracteriza por su capacidad para modular varios procesos fisiológicos, particularmente en el contexto de enfermedades inflamatorias e infecciones virales. El compuesto se estudia a menudo por sus posibles efectos terapéuticos contra condiciones como la pancreatitis y la fibrosis. Mesilato de camostat ha atraído atención por su posible eficacia contra ciertas infecciones virales, incluidas las causadas por coronavirus, debido a su mecanismo de acción que puede interferir con la entrada viral en las células huésped. En términos de propiedades físicas, se presenta típicamente como un polvo cristalino blanco a blanco amarillento, soluble en agua y en varios disolventes orgánicos. La sustancia se administra por vía oral y tiene una vida media relativamente corta, lo que requiere una cuidadosa consideración de los regímenes de dosificación en aplicaciones clínicas. En general, Mesilato de camostat representa un candidato prometedor en la investigación farmacológica, particularmente en los campos de la virología y la inflamación.

Fórmula: C₂₀H₂₂N₄O₅·CH₄O₃S

InChI: InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

Clave InChI: InChIKey=FSEKIHNIDBATFG-UHFFFAOYSA-N

SMILES: C(OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1)(=O)C2=CC=C(NC(=N)N)C=C2.S(C)(=O)(=O)O

Sinónimos:

• 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate
• Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1)
• Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, monomethanesulfonate
• Camostat mesylate
• Camostat monomethanesulfonate
• Foipan
• Foy 305
• Foy-S 980
• N-(diaminomethylidene)-4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilinium methanesulfonate

Camostat Mesylate

CAS: 59721-28-7, 59721-29-8

Fórmula: C₂₀H₂₂N₄O₅·CH₄O₃S

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 494.52

Ref: 3B-C2977

Camostat methanesulfate, 98%

CAS: 59721-29-8

An orally active synthetic serine protease inhibitor

Fórmula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Pureza: 98%

Forma y color: White to cream, Powder

Peso molecular: 494.52

Ref: 02-J62362

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate

Pureza: ≥98%

Peso molecular: 494.52g/mol

Ref: 54-BUP17156

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate

Fórmula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Pureza: 99.77% (Typical Value in Batch COA)

Forma y color: white solid

Peso molecular: 494.52g/mol

Ref: 54-BISN0316

Camostat mesylate

CAS: 59721-29-8

Fórmula: C₂₀H₂₂N₄O₅·CH₃SO₃H

Pureza: ≥ 98.0%

Forma y color: White crystalline powder or crystals

Peso molecular: 494.52

Ref: 7W-GP4306

Camostat Mesylate

CAS: 59721-29-8

Fórmula: C₂₀H₂₂N₄O₅·CH₄O₃S

Forma y color: White To Off-White Solid

Peso molecular: 398.42 96.10

Ref: 4Z-C-131001

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

Fórmula: C₂₁H₂₆N₄O₈S

Pureza: 99.31% - 99.85%

Forma y color: Crystalline Solid

Peso molecular: 494.52

Ref: TM-T2391

Camostat Mesilate RS

CAS: 59721-29-8

Forma y color: White

Ref: 2K-1037000021

Camostat mesylate

CAS: 59721-29-8

Camostat mesylate is an inhibitor of trypsin-like serine proteases such as trypsin, thrombin, plasmin, plasma kallikrein and urokinase-type plasminogen activator. Camostat mesylate has also been shown to inhibit trimming of the viral spike (S) protein in coronaviruses. Camostat mesylate inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.

Fórmula: C₂₀H₂₂N₄O₅•CH₄O₃S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 494.52 g/mol

Ref: 3D-FC19641

Camostat mesylate - Bio-X ™

CAS: 59721-29-8

Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.

Fórmula: C₂₀H₂₂N₄O₅•CH₄O₃S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 494.52 g/mol

Ref: 3D-BC164270

4-(2-(2-(Dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate

CAS: 59721-29-8

Pureza: 99%

Peso molecular: 494.519989

Ref: 10-F868964

Camostat Mesylate-D4

Producto controlado

CAS: 59721-29-8

Applications Camostat mesylate-D4 is a labelled analogue of Camostat mesylate (C150300).

Fórmula: C₂₀H₁₈D₄N₄O₅•CH₄O₃S

Forma y color: Neat

Peso molecular: 402.44 + 96.11

Ref: TR-C150303

Camostat Mesylate-D6

Producto controlado

CAS: 59721-29-8

Fórmula: C₂₀H₁₆D₆N₄O₅•CH₃SO₃H

Forma y color: Neat

Peso molecular: 500.56

Ref: TR-C150302

Methomyl

Producto controlado

CAS: 59721-29-8

Fórmula: C₂₀H₂₂N₄O₅·CH₄O₃S

Forma y color: Neat

Peso molecular: 494.52

Ref: TR-C150300

Camostat Mesilate

CAS: 59721-29-8

Camostat mesilate is a prodrug that is metabolized to the active form, pemastatin. It is used for the treatment of bowel disease and squamous cell carcinoma. Camostat mesilate inhibits the TNF-α receptor by binding to its response element in vitro and in vivo. The biological properties of camostat mesilate are due to its ability to inhibit TNF-α production by binding to the TNF-α receptor, thereby preventing activation of transcription factors such as nuclear factor kappa B (NFκB). In vitro assays have shown that camostat mesilate induces apoptosis in human carcinoma cell lines through inhibition of growth factor-β1. This drug has also been shown to be effective in treating viral infections, including HIV and herpes zoster.

Fórmula: C₂₀H₂₂N₄O₅•CH₃SO₃H

Pureza: Min. 95%

Peso molecular: 494.5 g/mol

Ref: 3D-ISP-3606-PI