CAS 59973-80-7

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)bencilideno]-1H-indeno-3-ácido acético

Descripción:

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)bencilideno]-1H-indeno-3-ácido acético, con el número CAS 59973-80-7, es un compuesto orgánico sintético caracterizado por sus características estructurales únicas. Contiene un átomo de flúor, un grupo metilo y un grupo metilsulfonilo, lo que contribuye a su potencial actividad biológica. La estructura central de indeno es notable por sus propiedades aromáticas, que pueden influir en la reactividad del compuesto y en sus interacciones con objetivos biológicos. Este compuesto probablemente exhiba lipofilia moderada a alta debido a sus regiones hidrofóbicas, lo que puede afectar su solubilidad y permeabilidad en sistemas biológicos. La presencia del grupo funcional ácido acético sugiere potencial para ionización a pH fisiológico, impactando su farmacocinética. Además, la configuración (Z) indica un arreglo geométrico específico alrededor del doble enlace, lo que puede influir significativamente en la actividad biológica del compuesto y en sus interacciones. En general, este compuesto puede ser de interés en la química medicinal, particularmente en el desarrollo de fármacos que apunten a vías biológicas específicas.

Fórmula: C₂₀H₁₇FO₄S

InChI: InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

Clave InChI: InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N

SMILES: C(C(O)=O)C=1C=2C(/C(=C\C3=CC=C(S(C)(=O)=O)C=C3)/C1C)=CC=C(F)C2

Sinónimos:

• (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (Z)-
• Aposulind
• Aptosyn
• Exisulind
• Fgn-1
• Prevatac(former Brand Name)
• Prevatec
• Sulindac sulfone
• cis-5-Fluoro-2-methyl-1-[p-methylsulfonylbenzylidenyl]indene-3-acetic acid
• 5-Fluoro-2-methyl-1-[(Z)-4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
• Unii-K619iig2R9
• (Z)-5-Fluoro-2-Methyl-1-[[4-(Methylsulfonyl)phenyl]Methylene]-1H-indene-3-acetic Acid
• APTOSYN/EXISULIND
• Ccris 7242
• Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)
• Sulindac Impurity 2（Sulindac EP Impurity B）
• (Z)-Sulindac Sulfone
• Sulindac EP Impurity B/ Sulindac Related Compound B ((Z)-Sulindac Sulfone)
• (Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID
• Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3- (1642020)
• Sulindac EP Impurity B (Sulindac Sulfone)
• Sulindac USP Related Compound B

Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid)

CAS: 59973-80-7

Other aromatic organo-sulfur compounds (excluding pesticides)

Fórmula: C₂₀H₁₇FO₄S

Forma y color: Yellow Crystalline Powder

Peso molecular: 372.08316

Ref: 45-1642020

1H-Indene-3-acetic acid,5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Pureza: 97%

Forma y color: Solid

Peso molecular: 372.4100

Ref: IN-DA00EC0N

Exisulind

CAS: 59973-80-7

Exisulind

Pureza: ≥95%

Peso molecular: 372.41g/mol

Ref: 54-BUP06388

Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Forma y color: Yellow Solid

Peso molecular: 372.41

Ref: 4Z-S-294

Sulindac EP Impurity B

Producto controlado

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Forma y color: Neat

Peso molecular: 372.41

Ref: 86-MM0624.02

(Z)-Sulindac Sulfone

CAS: 59973-80-7

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)

Fórmula: C₂₀H₁₇FO₄S

Forma y color: Neat

Peso molecular: 372.41

Ref: TR-S699225

Sulindac Sulfone-d6

Producto controlado

CAS: 59973-80-7

Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);

Fórmula: C₂₀H₁₁D₆FO₄S

Forma y color: Neat

Peso molecular: 378.45

Ref: TR-S699227

Sulindac sulfone

CAS: 59973-80-7

Sulindac sulfone is a nonsteroidal anti-inflammatory drug that belongs to the class of sulfones. It has been shown to inhibit the mcl-1 protein, which is involved in the mitochondrial apoptosis pathway. Sulindac sulfone inhibits prostaglandin E2 (PGE2) levels and mitochondrial membrane potential in vitro assays. Sulindac sulfone also has inhibitory properties against a number of enzymes including cyclooxygenase-2 (COX-2), lipoxygenases, phospholipases A2, and thromboxane synthase. These properties are responsible for its anti-inflammatory effects. Sulindac sulfone shows minimal toxicity due to its low bioavailability and lack of liver metabolism. This drug has been shown to have anticancer activity as well as an ability to inhibit infectious diseases such as Leishmania major and Helicobacter pylori.

Fórmula: C₂₀H₁₇FO₄S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 372.41 g/mol

Ref: 3D-FS27971

Sulindac EP Impurity B

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Peso molecular: 372.41

Ref: ST-EA-CP-S108002

Exisulind

CAS: 59973-80-7

Exisulind (CP248) triggers apoptosis via PKG activation, shows antitumor effects, and inhibits growth in various rodent cancer models.

Fórmula: C₂₀H₁₇FO₄S

Pureza: 97.94%

Forma y color: Solid

Peso molecular: 372.41

Ref: TM-T24051