CAS 61-72-3

Cloxacilina

Descripción:

Cloxacilina es un antibiótico penicilínico semisintético que se utiliza principalmente para tratar infecciones causadas por estafilococos productores de penicilinasa. Se caracteriza por su estructura de beta-lactama, que es esencial para su actividad antibacteriana. Cloxacilina es efectivo contra una variedad de bacterias Gram-positivas, particularmente Staphylococcus aureus, y es resistente a la degradación por ciertas beta-lactamasas, lo que lo convierte en una opción valiosa para tratar infecciones resistentes. El compuesto se administra típicamente por vía oral o intravenosa y es conocido por su perfil de toxicidad relativamente bajo. Su farmacocinética incluye una buena absorción del tracto gastrointestinal, aunque los alimentos pueden afectar su biodisponibilidad. Cloxacilina se metaboliza en el hígado y se excreta principalmente a través de los riñones. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, reacciones alérgicas y, en casos raros, efectos más graves como toxicidad hepática. Al igual que con todos los antibióticos, es crucial usar Cloxacilina de manera juiciosa para prevenir el desarrollo de resistencia a los antibióticos.

Fórmula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

Clave InChI: InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N

SMILES: N(C(=O)C=1C(=NOC1C)C2=C(Cl)C=CC=C2)[C@H]3[C@@]4(N([C@@H](C(O)=O)C(C)(C)S4)C3=O)[H]

Sinónimos:

• (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(O-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimet hyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-(((3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
• 6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
• 6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
• 6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid
• Brl 1621
• Clossacillina
• Clossacillina [DCIT]
• Cloxacilina
• Cloxacilina [INN-Spanish]
• Cloxacillin [INN:BAN]
• Cloxacilline
• Cloxacilline [INN-French]
• Cloxacillinum
• Cloxacillinum [INN-Latin]
• Hsdb 3042
• Methocillin S
• Methylchlorphenylisoxazoryl-penicillin
• Orbenin Extra Dry Cow
• Syntarpen
• Unii-O6X5Qgc2Vb

Cloxacillin Sodium Salt Monohydrate

CAS: 61-72-3, 642-78-4, 7081-44-9

Fórmula: C₁₉H₁₇ClN₃NaO₅S·H₂O

Pureza: >98.0%(HPLC)

Forma y color: White to Orange to Green powder to crystaline

Peso molecular: 475.88

Ref: 3B-C2244

Cloxacillin 1000 µg/mL in Acetonitrile

Producto controlado

CAS: 61-72-3

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: Single Solution

Peso molecular: 435.8813

Ref: 04-A11692090AL-1000

Cloxacillin

CAS: 61-72-3

Cloxacillin, a β-lactamase inhibitor, tackles S. aureus inflammation and has an IC50 of 0.04 µM.

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: Solid

Peso molecular: 435.88

Ref: TM-T73058

Cloxacilline-13c4

CAS: 61-72-3

Cloxacillin is a sulfa drug that inhibits bacterial growth by binding to the 50S ribosomal subunit. It inhibits the synthesis of bacterial cell walls by binding to dextran sulfate and polymerase chain. Cloxacillin has been shown to have experimental solubility data in various biological samples, such as human serum and wastewater treatment. Cloxacillin has also been shown to be effective against Streptococcus pyogenes (Group A streptococci) and Staphylococcus aureus, which are two common causes of infectious diseases. Cloxacillin may be used in combination with vancomycin therapy or benzalkonium chloride for these infections.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 95%

Peso molecular: 435.88 g/mol

Ref: 3D-FC175020

Oxacillin EP Impurity E

CAS: 61-72-3

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: ST-EA-CP-O58005