CAS 61825-94-3

Oxaliplatino

Descripción:

Oxaliplatino es un fármaco de quimioterapia a base de platino que se utiliza principalmente en el tratamiento del cáncer colorrectal. Se clasifica como un compuesto de platino de tercera generación y es conocido por su capacidad para formar enlaces cruzados en el ADN, lo que inhibe la replicación y transcripción del ADN, llevando finalmente a la muerte de las células cancerosas. Químicamente, Oxaliplatino es un complejo de platino de diaminociclohexano, que mejora su eficacia y reduce la probabilidad de resistencia en comparación con fármacos de platino anteriores como el cisplatino y el carboplatino. Se administra típicamente por vía intravenosa y a menudo se utiliza en combinación con otros agentes quimioterapéuticos. Oxaliplatino se caracteriza por su solubilidad moderada en agua y su estabilidad en condiciones fisiológicas, aunque puede sufrir hidrólisis en presencia de agua, lo que lleva a la formación de especies reactivas. Los efectos secundarios comunes incluyen neuropatía periférica, náuseas y mielosupresión. Su mecanismo de acción único y su perfil de efectos secundarios lo convierten en una opción valiosa en el arsenal terapéutico oncológico, particularmente para pacientes con cáncer colorrectal avanzado o metastásico.

Fórmula: C₈H₁₄N₂O₄Pt

InChI: InChI=1/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/rC8H14N2O4Pt/c11-7-8(12)14-15(13-7)9-5-3-1-2-4-6(5)10-15/h5-6H,1-4,9-10H2/t5-,6-/m1/s1

Clave InChI: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES: O=C1[O-][Pt+2]2([NH2][C@]3([C@]([NH2]2)(CCCC3)[H])[H])[O-]C1=O

Sinónimos:

• Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• platinum(2+) ethanedioate (1R,2R)-cyclohexane-1,2-diamine (1:1)
• NSC-266046
• [SP-4-2-(IR-trans)]-(1,2-cyclohexanediamine-n,n')[ethanedioato(2-)-O,O']-platinum
• (1R,2R)-cyclohexane-1,2-diamine: oxalic acid: platinum(+2) cation
• xalatoplatinum
• (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]platinum
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• latin
• cyclohexane-1,2-diamine: oxalic acid: platinum
• RP-54780
• (sp-4-2)-((1r,2r)-1,2-cyclohexanediamine-n,n')(ethanedioato(2-)-O,O']platinum
• Platinum, (1,2-cyclohexanediamine-N,N′)[ethanedioato(2-)-O,O′]-, [SP-4-2-(1R-trans)]-
• platinum(4+) cyclohexane-1,2-diyldiazanide ethanedioate (1:1:1)
• Elocatin
• Oxalipatin
• trans-L-Diaminocyclohexane oxalatoplatinum
• 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-
• ι-OHP
• [SP-4-2-(1R-trans)]-(1，2-Cyclohexanediamine-N，N，)[ethanedioato(2-)-O，O’Jplatinum
• OXALIPLATIN
• OXALIPIATIN
• Lipoxal
• SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N)[ETHANEDIOATO(2-)-O,OPT
• Oxaliplatin(Eloxatin)
• NSC-266046：Elocatin
• Eloxatin
• Cis-[(1R,2R)-1,2-cyclothexanediammine-N,N`][oxalato(2-)-O,O`]platinum
• Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
• P-54780
• oxalatoplatinum
• [SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM
• oxaliplatino
• Oxaliplatin (125 mg)
• platinuM(2+) ion (1R,2R)-cyclohexane-1,2-diaMine oxalate
• oxalatoplatin
• Oxaliplatin EP/BP
• (1R-trans)-1,2-Cyclohexanediamine, platinum complex
• [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N
• 1-ohp
• (1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr
• OxaliplatinEp5
• Dacplat
• Elplat
• OXALIPLATIN (oxaliplatin)
• oxalato(1r,2r-cyclohexanediammine)platinum(ii)
• [SP-4-2-（1R-trans）]-(1,2-Cyclohexanediamine-N,Nˊ)[ethanedioato(2-)-O,Oˊ]platinum
• (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
• Oxaliplatin99%
• Oxaliplatin API

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Forma y color: White to Almost white powder to crystal

Peso molecular: 397.29

Ref: 3B-O0372

OXALIPLATIN CRS

CAS: 61825-94-3

OXALIPLATIN CRS

Fórmula: C₈H₁₂N₂O₄Pt

Peso molecular: 395.2759

Ref: 41-Y0000271

Oxaliplatin

CAS: 61825-94-3

Inorganic or organic compounds of precious metals, whether or not chemically defined, or amalgams of precious metals, nesoi

Fórmula: C₈H₁₄N₂O₄Pt

Forma y color: White Off-White Powder

Peso molecular: 397.06015

Ref: 45-1481204

Trans-L-Diaminocyclohexane Oxalatoplatinum

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98%

Forma y color: Solid

Peso molecular: 397.2858

Ref: IN-DA0035Q1

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 97% - 99.93%

Forma y color: Solid

Peso molecular: 397.29

Ref: TM-T0164

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98.0 - 102.0 % (dried basis)

Forma y color: White to almost white crystalline powder

Peso molecular: 397.29

Ref: 7W-GP0792

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Pureza: ≥95%

Peso molecular: 397.29g/mol

Ref: 54-BUP16056

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98%

Forma y color: white solid

Peso molecular: 397.29g/mol

Ref: 54-BISN0119

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Forma y color: White To Off-White Solid

Peso molecular: 397.29

Ref: 4Z-O-242

Oxaliplatin, EP grade

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Peso molecular: 397.29

Ref: 7W-GP9874

Oxaliplatin

Producto controlado

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Forma y color: Neat

Peso molecular: 397.29

Ref: 86-MM0921.00

Oxaliplatin RS

CAS: 61825-94-3

Forma y color: White Solid Crystalline Powder

Ref: 2K-1032100021

Oxaliplatin

Producto controlado

CAS: 61825-94-3

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Fórmula: C₈H₁₄N₂O₄Pt

Forma y color: White To Off-White

Peso molecular: 397.29

Ref: TR-O845075

Oxaliplatin - Bio-X ™

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.
Oxaliplatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 397.29 g/mol

Ref: 3D-BO164182

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 397.29 g/mol

Ref: 3D-FD26607

Oxaliplatin

CAS: 61825-94-3

Pureza: 98%

Peso molecular: 397.06

Ref: 10-F556520