CAS 62996-74-1

Estaurosporina

Descripción:

Estaurosporina es un potente alcaloide derivado de la bacteria Streptomyces staurosporeus, conocido por sus efectos inhibitorios de amplio espectro sobre las quinasas. Se caracteriza por su compleja estructura tetracíclica, que contribuye a su actividad biológica. Estaurosporina exhibe una alta afinidad por varias quinasas, incluidas las involucradas en las vías de señalización celular, lo que lo convierte en una herramienta valiosa en la investigación para estudiar procesos celulares como la apoptosis y la proliferación celular. El compuesto se utiliza típicamente en entornos de laboratorio para investigar los mecanismos del cáncer y otras enfermedades. Estaurosporina también es reconocido por sus posibles aplicaciones terapéuticas, aunque su uso está limitado debido a su naturaleza no selectiva y la toxicidad asociada. En términos de propiedades físicas, es un sólido cristalino que es soluble en disolventes orgánicos pero tiene una solubilidad limitada en agua. Como sustancia química de investigación, es importante manejar Estaurosporina con cuidado, cumpliendo con los protocolos de seguridad debido a sus potentes efectos biológicos.

Fórmula: C₂₈H₂₆N₄O₃

InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/p+1/t17-,20-,26-,28+/m1/s1

Clave InChI: InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8

Sinónimos:

• (5R,6S,7S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5R,6S,7S,9S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-N,5-dimethyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-aminium
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
• 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• Alkaloid AM-2282 from Streptomyces
• Am-2282
• Antibiotic 230
• Antibiotic AM 2282
• Ccris 3272
• Cgp 39360
• Staurosporin
• (+)-Staurosporine
• Staurosporine
• STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
• [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• Staurosporine,AM-2282,STS
• STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+%
• Stauroporine
• [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE
• 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE
• STAUROSPORINE, STREPTOMYCES STAUROSPOREUS
• STAUROSPORINE, STREPTOMYCES SPECIES
• Staurosporine, Antibiotic AM-2282
• (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt
• STAUROSPORINE, 99+%.
• ANTIBIOTIC M 193
• 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• STSP
• Staurosporineinsolution
• InSolution Staurosporine, Streptomyces sp
• Staurosporine,98%
• [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• STAUROSPORINE READY-MADE SOLUTION
• STAUROSPORINE FROM STREPTOMYCES SP.
• Staurosporine(CGP 41251)
• [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 466.54

Ref: 3B-T4000

Staurosporine, 99+%

CAS: 62996-74-1

Staurosporine, 62996-74-1, is a cell-permeable bacterial alkyloid and protein kinase inhibitor with anti-cancer properties. Learn more at Thermo Fisher Scientific.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 99+%

Forma y color: Crystalline powder or granular, White to pale cream to yellow

Peso molecular: 466.54

Ref: 02-J62837

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 100.0%

Forma y color: Yellow powder

Peso molecular: 466.0

Ref: 8R-PB0005

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 466.5310

Ref: IN-DA00365L

Staurosporine

CAS: 62996-74-1

Staurosporine

Pureza: ≥98%

Peso molecular: 466.53g/mol

Ref: 54-BUP12221

Staurosporine, from Streptomyces sp.

CAS: 62996-74-1

Staurosporine, from Streptomyces sp.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 98%

Forma y color: off-white powder

Peso molecular: 466.53103g/mol

Ref: 54-BIS0504

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Peso molecular: 466.54

Ref: 4Z-S-172001

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Forma y color: Neat

Peso molecular: 466.53

Ref: 04-C16974200

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: (HPLC) ≥ 98.0%

Forma y color: Off-white to yellow solid

Peso molecular: 466.54

Ref: 7W-GA8507

Staurosporine

CAS: 62996-74-1

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 99.24% - 99.82%

Forma y color: Off-White Powder

Peso molecular: 466.53

Ref: TM-T6680

Staurosporine

Producto controlado

CAS: 62996-74-1

Inhibitor of protein kinases; induces apoptosis; anti-cancer

Fórmula: C₂₈H₂₆N₄O₃

Pureza: Min. 98 Area-%

Forma y color: Off-White Powder

Peso molecular: 466.53 g/mol

Ref: 3D-AS27871

Staurosporine

CAS: 62996-74-1

Pureza: 98%

Peso molecular: 466.2

Ref: 10-F795841

Staurosporin

Producto controlado

CAS: 62996-74-1

Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),

Fórmula: C₂₈H₂₆N₄O₃

Forma y color: Neat

Peso molecular: 466.53

Ref: TR-S685000

Staurosporine

CAS: 62996-74-1

Staurosporine is a fluorogenic substrate for the enzyme staurosporinase that is used in food testing, environmental testing, and diagnostics. It can be conjugated to an antibody or other protein to produce a ligand that binds to a receptor on the cell surface. Staurosporine has been shown to inhibit the activity of various enzymes including phospholipase A2, phospholipase C, and protein kinase C. It also inhibits bacterial DNA gyrase and topoisomerase IV. The fluorescence of staurosporine can be detected with luminometers or fluorescent microscopes.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: Min. 95%

Peso molecular: 466.53 g/mol

Ref: 3D-AS182928

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Peso molecular: 466.5

Ref: ST-EA-CP-M107008