CAS 63968-64-9

Artemisinina

Descripción:

Artemisinina es un lactona sesquiterpénica con la fórmula química C15H22O5, derivada principalmente de la planta de ajenjo dulce, Artemisia annua. Es conocida por sus potentes propiedades antipalúdicas y es un componente clave en las terapias combinadas basadas en Artemisinina (ACT) utilizadas para tratar la malaria. El compuesto presenta un puente endoperóxido único, que es crucial para su actividad biológica. Artemisinina exhibe una solubilidad moderada en disolventes orgánicos como el etanol y el cloroformo, pero tiene una solubilidad limitada en agua. Su mecanismo de acción implica la generación de especies reactivas de oxígeno tras la activación por hemo, lo que lleva a la destrucción de los parásitos de la malaria. Artemisinina generalmente es bien tolerado, aunque puede causar efectos secundarios como náuseas y mareos en algunos pacientes. Debido a su origen natural y eficacia, la investigación continúa en la optimización de sus derivados y en la mejora de sus propiedades farmacológicas. Además, los estudios en curso están explorando sus posibles aplicaciones más allá de la malaria, incluyendo sus efectos en varios tipos de cáncer y otras enfermedades.

Fórmula: C₁₅H₂₂O₅

InChI: InChI=1/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14+,15-/m1/s1

Clave InChI: InChIKey=BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(OC1=O)[H])[H]

Sinónimos:

• (+)-Arteannuin
• (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• (3S,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (5aS,6R,8aS,9R,12S)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-
• 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• ARTIVeda
• Artemef
• Artemisine
• Artemisinine
• Hc 101A
• Huanghuahaosu
• NSC 369397
• PulmoHeal
• Qing Hau Sau
• Qing Hau Su
• Qinghaosu
• Qinghosu
• [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• Artemisinin
• Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
• ARTEANUIN
• (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar*)-(+)-methyl
• Artemisinin Qinghaosu/ [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• ARTEMISININ (QINGHAOSU)
• SWEET WORMWOOD
• artemisiaannual.,extract
• ARTEMETHER
• 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tri
• ArteMisinin, 98%, froM ArteMisia annua L.
• qinghausau
• ARTEMISININ 99%
• 3,13-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)one,(ctahydro-3,6,9-trimethyl-,[3R-(3α,5αβ,6β,8αβ,9α,12β,12αR*)]-
• Arteannuin99%
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• Artemisinine,98%
• QHS
• Astemisinin
• Arteannuin, Qinghaosu
• ARTEMISIA P E
• QINGHAOSA
• octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(
• ALPHA BETA ARTEMISININ
• Quinghaosu
• qinghausu
• ArteMisinin, froM ArteMisia annua
• 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(+)
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3 ,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• ARTEMISIA ANNUA
• Artemisine，Artemisinin，Arteannuin
• Artemisia annual L Ext.

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: >97.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 282.34

Ref: 3B-A2118

Artemisinin, 98%

CAS: 63968-64-9

Artemisinin inhibits angiogenesis by down-regulating HIF-1 and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio.

Fórmula: C₁₅H₂₂O₅

Pureza: 98%

Forma y color: Crystals or crystalline powder, White

Peso molecular: 282.34

Ref: 02-J65406

ARTEMISININ RS

CAS: 63968-64-9

ARTEMISININ RS

Fórmula: C₁₅H₂₂O₅

Forma y color: Powder

Peso molecular: 282.3322

Ref: 41-ICRS43857

Artemisinin

CAS: 63968-64-9

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₁₅H₂₂O₅

Forma y color: White Off-White Solid

Peso molecular: 282.14672

Ref: 45-1042747

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 282.3322

Ref: IN-DA00IBB0

Artemisinin

CAS: 63968-64-9

Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.

Fórmula: C₁₅H₂₂O₅

Pureza: 99.77% - 99.87%

Forma y color: Crystalline Solid

Peso molecular: 282.33

Ref: TM-T0392

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: (HPLC) ≥ 98.0%

Forma y color: White to off-white crystalline powder

Peso molecular: 282.33

Ref: 7W-GP0718

Artemisinin

CAS: 63968-64-9

Artemisinin

Pureza: ≥95%

Peso molecular: 282.33g/mol

Ref: 54-BUP16845

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Peso molecular: 282.34

Ref: 4Z-A-309

Artemisinin

CAS: 63968-64-9

Forma y color: Neat

Ref: 86-MM0803.00

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: 95%~99%

Peso molecular: 282.336

Ref: BP-BP0197

Artemisinin

CAS: 63968-64-9

Artemisinin

Fórmula: C₁₅H₂₂O₅

Pureza: 97%

Forma y color: white crystalline needles

Peso molecular: 282.33g/mol

Ref: 54-BIA4320

Artemisinin

CAS: 63968-64-9

Lactone

Fórmula: C₁₅H₂₂O₅

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 282.34

Ref: 5G-89484

Artemisinin

CAS: 63968-64-9

Artemisinin is a sesquiterpene lactone, which is derived from the plant Artemisia annua, commonly known as sweet wormwood. This compound is isolated through a series of extraction and purification processes from the plant's leaves and flowers. Artemisinin exerts its pharmacological effect through a novel mode of action that involves endoperoxide bridges, which interact with intracellular iron to generate free radicals. These reactive species subsequently damage vital biomolecules within Plasmodium parasites, effectively inhibiting their ability to thrive and reproduce.

Fórmula: C₁₅H₂₂O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 282.33 g/mol

Ref: 3D-FA09640

Artemisinin-d4

Producto controlado

CAS: 63968-64-9

Fórmula: C₁₅D₄H₁₈O₅

Forma y color: Neat

Peso molecular: 286.357

Ref: TR-A777503

Artemisinin-13C-D3

Producto controlado

CAS: 63968-64-9

Fórmula: CC₁₄D₃H₁₉O₅

Forma y color: Neat

Peso molecular: 286.343

Ref: TR-A777504

Artesunate IP Impurity B

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Peso molecular: 282.34

Ref: ST-EA-CP-A93012

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Forma y color: White to Off-White Solid

Peso molecular: 282.33

Ref: TR-A777500