CAS 64-77-7

Tolbutamida

Descripción:

Tolbutamida es un medicamento de la clase de las sulfonilureas que se utiliza principalmente en el manejo de la diabetes mellitus tipo 2. Funciona estimulando la secreción de insulina de las células beta pancreáticas, lo que reduce los niveles de glucosa en sangre. Químicamente, Tolbutamida se caracteriza por su fórmula molecular, que incluye un grupo sulfonilo y un anillo aromático, contribuyendo a su actividad farmacológica. Se presenta típicamente como un polvo cristalino blanco a blanco sucio, con una solubilidad relativamente baja en agua, lo que puede afectar su absorción y biodisponibilidad. El compuesto tiene un punto de fusión moderado y es estable en condiciones normales, aunque debe almacenarse alejado de la luz y la humedad para mantener su eficacia. Tolbutamida se metaboliza en el hígado, y sus efectos pueden variar según factores individuales del paciente, incluida la función renal. Al igual que con cualquier medicamento, puede tener efectos secundarios, incluidos hipoglucemia y trastornos gastrointestinales, y debe usarse bajo supervisión médica.

Fórmula: C₁₂H₁₈N₂O₃S

InChI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Clave InChI: InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N

SMILES: S(NC(NCCCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Sinónimos:

• 1-Butyl-3-(4-methylphenyl)sulfonylurea
• 1-Butyl-3-(p-methylphenylsulfonyl)urea
• 1-Butyl-3-(p-tolylsulfonyl)urea
• 1-Butyl-3-tosylurea
• 3-(p-Tolyl-4-sulfonyl)-1-butylurea
• 3-Butyl-1-(4-methylbenzenesulfonyl)urea
• Aglicid
• Arkozal
• Artosin
• Artozin
• Benzenesulfonamide, N-[(Butylamino)Carbonyl]-4- Methyl-
• Butamid
• Butamide
• D 860
• Diaben
• Diabetamid
• Diabetol
• Diabuton
• Diasulfon
• Dolipol
• Glyconon
• Hls 831
• Ipoglicone
• Mobenol
• N-(4-Methylbenzene) sulfonyl-N'-butylurea
• N-(4-Methylbenzenesulfonyl)-N'-butylurea
• N-(4-Methylphenylsulfonyl)-N'-butylurea
• N-(Sulfonyl-p-methylbenzene)-N'-n-butylurea
• N-(p-Methylbenzenesulfonyl)-N'-butylurea
• N-(p-Tolylsulfonyl)-N'-butylcarbamide
• N-Butyl-N'-(4-methylphenylsulfonyl)urea
• N-Butyl-N'-(P-Tolylsulfonyl)-Harnstoff
• N-Butyl-N'-(p-tolylsulfonyl)urea
• N-Butyl-N'-p-toluenesulfonylurea
• N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
• N-n-Butyl-N'-tosylurea
• Nsc 23813
• Nsc 87833
• Orabet
• Oralin
• Orezan
• Orinase
• Orinaz
• Oterben
• Pramidex
• Rastinon
• Tolbusal
• Tolbutamid
• Tolbutamida
• Toluina
• Tolumid
• Tolumide
• Toluvan
• U 2043
• Urea, 1-butyl-3-(p-tolylsulfonyl)-

Tolbutamide, 98%

CAS: 64-77-7

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic -cells. The activity of various bio

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: 98%

Forma y color: White to pale cream, Powder or crystalline powder

Peso molecular: 270.35

Ref: 02-B21698

Tolbutamide 1.0 mg/ml in Acetonitrile

CAS: 64-77-7

Forma y color: Single Solution

Ref: 61-AMP1089.00-11

TOLBUTAMIDE CRS

CAS: 64-77-7

TOLBUTAMIDE CRS

Fórmula: C₁₂H₁₈N₂O₃S

Forma y color: Crystalline Powder. White. Powder.

Peso molecular: 270.3479

Ref: 41-T1700000

Tolbutamide

CAS: 64-77-7

Sulfonamides used as drugs

Fórmula: C₁₂H₁₈N₂O₃S

Forma y color: White Crystalline Powder

Peso molecular: 270.10381

Ref: 45-1670003

Tolbutamide

CAS: 64-77-7

Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: 99.80% - 99.93%

Forma y color: White Crystalline Powder

Peso molecular: 270.35

Ref: TM-T1054

Benzenesulfonamide, N-​[(butylamino)​carbonyl]​-​4-​methyl-

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: 98%

Forma y color: Solid

Peso molecular: 270.3479

Ref: IN-DA00E9I8

Tolbutamide

CAS: 64-77-7

Tolbutamide

Pureza: ≥98%

Peso molecular: 270.35g/mol

Ref: 54-BUP18358

Tolbutamide

CAS: 64-77-7

Tolbutamide

Pureza: 99%

Peso molecular: 270.35g/mol

Ref: 54-OR1028654

Tolbutamide

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Peso molecular: 270.35

Ref: 7W-GP0797

Tolbutamide

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 270.35

Ref: 3B-T3690

Tolbutamide

Producto controlado

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Forma y color: Neat

Peso molecular: 270.35

Ref: 86-MM1089.00

Tolbutamide

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Forma y color: Neat

Peso molecular: 270.35

Ref: 04-C17589900

Tolbutamide

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Peso molecular: 270.35

Ref: 4Z-T-048

Tolbutamide RS

CAS: 64-77-7

Forma y color: White

Ref: 2K-1099000021

Tolbutamide

Producto controlado

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Forma y color: Off-White

Peso molecular: 270.35

Ref: TR-T535150

Tolbutamide

CAS: 64-77-7

Tolbutamide is a drug that is used to treat diabetes mellitus type 2. It is an inhibitor of the enzyme glucokinase and thus blocks the phosphorylation of glucose, which prevents its utilization by cells. This results in a decrease of blood glucose levels, which can be useful in the treatment of diabetes mellitus type 2. Tolbutamide has shown potent apoptosis-inducing effects on human breast cancer cells and endothelial cells. These effects are thought to be due to inhibition of protein kinase C (PKC) activity by tolbutamide. Additionally, this drug inhibits insulin secretion from pancreatic beta cells and induces cytochrome P450 enzymes, which may lead to increased metabolism of other drugs.

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: Min. 95%

Peso molecular: 270.35 g/mol

Ref: 3D-FT28304

Tolbutamide

CAS: 64-77-7

Fórmula: C₁₂H₁₈N₂O₃S

Pureza: 98%

Forma y color: Solid

Peso molecular: 270.35

Ref: 10-F047218

Tolbutamide

CAS: 64-77-7

Forma y color: Neat

Ref: 61-FOR1089.00