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CAS 65147-06-0

:

Boc-Ile-Glu-Gly-Arg-AMC

Descripción:
Boc-Ile-Glu-Gly-Arg-AMC es un sustrato de péptido sintético comúnmente utilizado en la investigación bioquímica, particularmente en estudios que involucran enzimas proteolíticas. El nombre indica que es un derivado de los aminoácidos isoleucina (Ile), ácido glutámico (Glu), glicina (Gly) y arginina (Arg), con un grupo protector Boc (tert-butiloxicarbonilo) en el residuo de isoleucina. El moiety AMC (7-amino-4-metilcumarina) sirve como un reportero fluorescente, permitiendo el monitoreo de la actividad enzimática a través de ensayos de fluorescencia. Este compuesto se utiliza típicamente en ensayos para estudiar proteasas, ya que la ruptura del enlace peptídico por la enzima libera el grupo AMC, resultando en un aumento de la fluorescencia que puede medirse cuantitativamente. La estabilidad del grupo Boc bajo ciertas condiciones lo hace adecuado para varios montajes experimentales. En general, Boc-Ile-Glu-Gly-Arg-AMC es una herramienta valiosa en el campo de la enzimiología y la química de péptidos, ayudando en la comprensión de la cinética enzimática y la especificidad del sustrato.
Fórmula:C34H50N8O10
InChI:InChI=1/C34H50N8O10/c1-7-18(2)28(42-33(50)52-34(4,5)6)31(49)40-23(12-13-26(44)45)29(47)38-17-25(43)41-30(48)22(9-8-14-37-32(35)36)39-20-10-11-21-19(3)15-27(46)51-24(21)16-20/h10-11,15-16,18,22-23,28,39H,7-9,12-14,17H2,1-6H3,(H,38,47)(H,40,49)(H,42,50)(H,44,45)(H4,35,36,37)(H,41,43,48)/t18-,22-,23-,28-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=N[C@@H](CCC(=O)O)C(=NCC(=NC(=O)[C@H](CCCNC(=N)N)Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)N=C(O)OC(C)(C)C
Sinónimos:
  • tertiary-Butyloxycarbonyl-isoleucyl-glutamyl-glycyl-arginyl-7-amino-4-methylcoumarin
  • Biggam
  • Boc-ile-glu-gly-arg-mca
  • L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • N-(tert-butoxycarbonyl)-L-isoleucyl-L-alpha-glutamyl-N-{(2S)-5-[(diaminomethylidene)amino]-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanoyl}glycinamide
  • Boc-Ile-Glu-Gly-Arg-Amc Acetate Salt
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Encontrado 4 productos.
  • Boc-Ile-Glu-Gly-Arg-AMC
    Bachem
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    Boc-IEGR-AMC, a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. The use of this substrate in the indirect determination of coagulation factor IX has been described.
    Fórmula:C34H50N8O10
    Pureza:97.8%
    Forma y color:White Powder
    Peso molecular:730.82

    Ref: 01-4004961

    25mg
    337,00€
    100mg
    982,00€
  • Boc-Ile-Glu-Gly-Arg-AMC
    Targetmol
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-IEGR-AMC: fluorogenic substrate for factor Xa and Halocynthia roretzi acrosin.</p>
    Fórmula:C34H50N8O10
    Pureza:98%
    Forma y color:White Powder
    Peso molecular:730.81

    Ref: TM-TP1129

  • Boc-Ile-Glu-Gly-Arg-AMC
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC is a cell permeable inhibitor of protein interactions that binds to the peptide sequences of the extracellular domain of the epidermal growth factor receptor (EGFR). Boc-Ile-Glu-Gly-Arg-AMC can be used as a research tool to study protein interactions, as well as an inhibitor for EGFR. It is soluble in DMSO and water. This product has been shown to inhibit the activity of ion channels such as voltage dependent calcium channels, potassium channels, and sodium channels. Boc-Ile-Glu-Gly-Arg-AMC also inhibits antibody binding to its antigen.</p>
    Fórmula:C34H50N8O10
    Pureza:Min. 95%
    Peso molecular:730.81 g/mol

    Ref: 3D-MIE-3094-V

    5mg
    278,00€
  • Boc-Ile-Glu-Gly-Arg-AMC acetate salt
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC acetate salt

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC acetate salt is a homologous peptide derived from soybean trypsin inhibitor. It has a molecular weight of 7,000 daltons and inhibits the activity of serine proteases, including kallikrein, plasmin, and thrombin. This peptide has been shown to be an inhibitor of heparin coagulation factor Xa and tissue factor in vitro. Boc-Ile-Glu-Gly-Arg-AMC acetate salt also has anticoagulant properties in vivo which are due to its ability to inhibit the synthesis of prothrombin.</p>
    Fórmula:C34H50N8O10·C2H4O2
    Pureza:Min. 95%
    Forma y color:Solid
    Peso molecular:790.86 g/mol

    Ref: 3D-FB110485

    1g
    1.998,00€