CAS 65147-09-3

N-T-boc-leu-gly-arg 7-amido-4-*metilcumarina ace

Descripción:

N-T-boc-leu-gly-arg 7-amido-4-metilcumarina acetato, identificado por su número CAS 65147-09-3, es un compuesto sintético comúnmente utilizado en investigación bioquímica, particularmente en el estudio de enzimas proteolíticas y síntesis de péptidos. Este compuesto presenta un grupo protector de tert-butiloxicarbonilo (Boc), que se emplea a menudo para proteger las funcionalidades aminas durante las reacciones químicas. La presencia de los aminoácidos leucina (leu), glicina (gly) y arginina (arg) en su estructura indica que es un derivado de péptido, lo que puede influir en su actividad biológica e interacciones. La porción 7-amido-4-metilcumarina sirve como una etiqueta fluorescente, haciéndola útil para monitorear la actividad enzimática o la escisión de péptidos en varios ensayos. El grupo acetato mejora la solubilidad y estabilidad en sistemas biológicos. En general, este compuesto es valioso en el desarrollo de sondas basadas en péptidos y en la exploración de la cinética enzimática, contribuyendo a los avances en campos como el descubrimiento de fármacos y la biología molecular.

Fórmula: C₂₉H₄₃N₇O₇

Sinónimos:

• Boc-Leu-Gly-Arg-AMC
• Boc-Leu-Gly-Arg-Amc Acetate Salt
• N(tert-BOC)-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate
• L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]-L-leucylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-T-boc-leu-gly-arg 7-amido-4-*methylcoumarin ace
• BOC-LEU-GLY-ARG-AMC ACOH
• BOC-LEU-GLY-ARG-MCA HYDROCHLORIDE
• N-T-BOC-LEU-GLY-ARG 7-AMIDO-4-METHYLCOUMARIN ACETATE)
• BOC-LGR-AMC
• N-ALPHA-T-BOC-L-LEU-GLY-L-ARG-4-METHYLCOUMARYL-7-AMIDE
• BOC-LEU-GLY-ARG-MCA
• Boc-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate salt

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-LGR-AMC, a specific fluorogenic substrate for complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme. It is also hydrolyzed by macropain, a high molecular weight thiol proteinase from human erythrocytes. Stock solutions of Boc-LGR-AMC are best prepared in DMSO.

Fórmula: C₂₉H₄₃N₇O₇

Pureza: > 99%

Forma y color: White Lyophilisate

Peso molecular: 601.7

Ref: 01-4005550

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC

Pureza: ≥98%

Peso molecular: 601.71g/mol

Ref: 54-BUP22193

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a fluorogenic substrate for detecting C3/C5 convertases, factor Xa, and soybean trypsin-like enzymes; it's also hydrolyzed by macropain.

Fórmula: C₂₉H₄₃N₇O₇

Pureza: 99.53%

Forma y color: Solid

Peso molecular: 601.69

Ref: TM-TP2169

Boc-Leu-Gly-Arg-AMC acetate salt

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC acetate salt is a potential drug target for leishmaniasis. It inhibits the growth of Leishmania by binding to the 17β-estradiol receptor and inhibiting protein synthesis. This drug also has a hydrolytic activity against proteins, which is activated by an acidic environment. It has been shown to inhibit the growth of bacteria including Staphylococcus aureus and Chlamydia pneumoniae by inhibiting urokinase-type plasminogen activator (uPA) and serine protease activities. Boc-Leu-Gly-Arg-AMC acetate salt has also been shown to inhibit cellular proliferation in cancer cells.

Fórmula: C₂₉H₄₃N₇O₇•C₂H₄O₂

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 661.74 g/mol

Ref: 3D-FB110486

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a peptide that binds to the receptor for N-methyl-D-aspartate (NMDA) and inhibits the ion channel. It has been used as a research tool to study NMDA receptor interactions, as well as in cell biology and pharmacology. Boc-Leu-Gly-Arg-AMC is a high purity, ionic analog of glutamate that binds to the NMDA receptor without activating it, thereby inhibiting ion flow through the channel. This inhibition can be reversed by adding excess glutamate or glycine. The binding of this compound to the NMDA receptor has been shown to block activation of voltage gated calcium channels and reduce neuronal excitation, which may provide an alternative therapeutic strategy for controlling seizures or other neurological disorders.

Fórmula: C₂₉H₄₃N₇O₇

Pureza: Min. 95%

Peso molecular: 601.69 g/mol

Ref: 3D-MLG-3102-V