CAS 654671-77-9
:Fosfato de sitagliptina monohidrato
Descripción:
Fosfato de sitagliptina monohidrato es un compuesto farmacéutico utilizado principalmente en el manejo de la diabetes mellitus tipo 2. Funciona como un inhibidor de la dipeptidil peptidasa-4 (DPP-4), lo que aumenta los niveles de incretina en el cuerpo, llevando a un aumento en la secreción de insulina y a una disminución de los niveles de glucagón en respuesta a las comidas. Este mecanismo ayuda a reducir los niveles de glucosa en sangre. La sustancia aparece como un polvo cristalino blanco a blanco sucio y es soluble en agua, lo que facilita su absorción en el cuerpo. Su fórmula molecular incluye elementos como carbono, hidrógeno, nitrógeno, oxígeno y fósforo, reflejando su estructura compleja. Fosfato de sitagliptina monohidrato se administra típicamente por vía oral y a menudo se prescribe en combinación con otros medicamentos antidiabéticos para mejorar el control glucémico. Al igual que con cualquier medicamento, es esencial monitorear los posibles efectos secundarios, que pueden incluir problemas gastrointestinales o reacciones alérgicas. En general, Fosfato de sitagliptina monohidrato representa un avance significativo en el tratamiento de la diabetes, ofreciendo un enfoque dirigido para manejar los niveles de azúcar en sangre.
Fórmula:C16H15F6N5O·H3O4P·H2O
InChI:InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
Clave InChI:InChIKey=GQPYTJVDPQTBQC-KLQYNRQASA-N
SMILES:C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)CC2)=NN1.P(=O)(O)(O)O.O
Sinónimos:- (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogen phosphate monohydrate
- (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate (1:1:1)
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate, hydrate (1:1:1)
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate
- Sitagliptin Phosphate Monohydrate
- Sitagliptin phosephate monohydrate
- Sitagliptin phosphate hydrate
Ordenar por
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Encontrado 18 productos.
Sitagliptin Phosphate
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFórmula:C16H15F6N5O·H3PO4·H2OForma y color:White Off-White PowderPeso molecular:523.105541,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
CAS:Fórmula:C16H20F6N5O6PPureza:98%Forma y color:SolidPeso molecular:523.3241Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydratePureza:≥98%Peso molecular:523.33g/molSitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydratePureza:98%Peso molecular:523.32g/molSitagliptin phosphate monohydrate
CAS:Fórmula:C16H15F6N5O·H3PO4·H2OPureza:≤ 0.5%Forma y color:White to almost white powderPeso molecular:505.31Sitagliptin Monophosphate Monohydrate
CAS:Fórmula:C16H15F6N5O·H2O·H3O4PForma y color:White To Off-White SolidPeso molecular:407.32 18.02 98.00Sitagliptin Phosphate Monohydrate
CAS:Producto controladoFórmula:C16H15F6N5O·H2O·H3O4PForma y color:NeatPeso molecular:523.32Sitagliptin phosphate hydrate
CAS:Fórmula:C16H15F6N5O·H3PO4·xH2OPureza:≥ 98.0% (anhydrous)Forma y color:White to off-white powderPeso molecular:505.31Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Fórmula:C16H15F6N5O·H3PO4·H2OPureza:99.85% - 99.98%Forma y color:White Or Almost White Crystalline PowderPeso molecular:523.33Sitagliptin Phosphate Monohydrate (Secondary Standards Traceable to USP)
CAS:Fórmula:C16H15F6N5OH3O4PH2OPeso molecular:407.3 : 98.0 : 18.0Sitagliptin phosphate monohydrate - Bio-X ™
CAS:Sitagliptin is a drug that can be used to treat type 2 diabetes. This drug increases the production of an incretin hormone called glucagon-like peptide-1 (GLP-1) by stimulating the GLP-1 receptor. Sitagliptin is used in combination with metformin or a thiazolidinedione to improve glycemic control in patients with type 2 diabetes mellitus. Sitagliptin has been shown to improve postprandial blood glucose levels and reduce the risk of cardiovascular events. It also reduces the incidence of myocardial infarction and congestive heart failure in patients with type 2 diabetes who are already at high risk for these conditions.Fórmula:C16H20F6N5O6PPureza:(%) Min. 95%Forma y color:PowderPeso molecular:523.32 g/molSitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate is a DPP-IV inhibitor that is used to treat type 2 diabetes mellitus. Sitagliptin decreases postprandial glucose levels and improves glycemic control. It binds to the enzyme DPP-IV, which breaks down peptides in the small intestine, inhibiting the breakdown of incretin hormones such as glucagon-like peptide 1 and glucose transporter type 2 (GLUT2). This leads to increased levels of GLP-1. Sitagliptin also has been shown to have an anti-diabetic effect by increasing insulin release from pancreatic beta cells.</p>Fórmula:C16H20F6N5O6PPureza:Min. 95%Forma y color:White PowderPeso molecular:523.32 g/mol
![1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrah…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00IBHW.jpg&w=3840&q=75)
