CAS 656247-17-5

Nintedanib

Descripción:

Nintedanib es un inhibidor de la tirosina quinasa de moléculas pequeñas utilizado principalmente en el tratamiento de ciertos tipos de cáncer y enfermedades pulmonares. Se caracteriza por su capacidad para inhibir múltiples tirosina quinasas de receptores, incluidos aquellos involucrados en la angiogénesis, fibrosis y crecimiento tumoral. La fórmula química de Nintedanib es C27H29N5O3, y tiene un peso molecular de aproximadamente 463.55 g/mol. Nintedanib se administra típicamente por vía oral y es conocido por su solubilidad moderada a alta en disolventes orgánicos, mientras que es menos soluble en agua. El compuesto exhibe una estructura compleja con un núcleo bicíclico, que contribuye a su actividad farmacológica. Su mecanismo de acción implica el bloqueo de vías de señalización que promueven la proliferación y supervivencia celular, lo que lo hace efectivo en condiciones como el cáncer de pulmón de células no pequeñas y la fibrosis pulmonar idiopática. Al igual que muchos fármacos, Nintedanib puede tener efectos secundarios, incluidos trastornos gastrointestinales y elevaciones de enzimas hepáticas, lo que requiere un monitoreo cuidadoso durante el tratamiento.

Fórmula: C₃₁H₃₃N₅O₄

InChI: InChI=1/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

Clave InChI: InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N

SMILES: C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5

Sinónimos:

• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
• Bibf-1120
• Intedanib
• Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
• Vargatef
• methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
• Nintedanib
• 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone
• Nintedanib impurity 1
• methyl (Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
• methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
• 3-[(4-{Methyl-[2-(4-methyl-piperazin-1-yl)-acetyl]-amino}-phenylamino)-phenyl-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
• Nintedanib/Intedanib/Vargatef
• Nintedanib, Free Base, >99%
• methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate
• Vargatef (nintedanib)
• Nintedanib (BIBF 1120)
• BIBF-1120(Nintedanib,Vargatef)
• NTEDANIB
• (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic acid methyl ester

Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

CAS: 656247-17-5

Pureza: 99+%

Forma y color: Powder or crystals

Peso molecular: 539.62

Ref: BD-BD161908

Nintedanib

CAS: 656247-17-5

Pureza: 97.0%

Forma y color: Solid, No data available.

Peso molecular: 539.635986328125

Ref: 10-F050741

(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

CAS: 656247-17-5

Fórmula: C₃₁H₃₃N₅O₄

Pureza: 99%

Forma y color: Solid

Peso molecular: 539.6248

Ref: IN-DA00FBZI

Nintedanib-13C-d3

CAS: 656247-17-5

Fórmula: C₃₀₁₃CH₃₀D₃N₅O₄

Forma y color: Yellow Solid

Peso molecular: 543.65

Ref: 4Z-N-066020

Nintedanib

CAS: 656247-17-5

Nintedanib

Pureza: 99%

Peso molecular: 539.62g/mol

Ref: 54-OR1029991

Nintedanib

CAS: 656247-17-5

Fórmula: C₃₁H₃₃N₅O₄

Forma y color: Yellow Solid

Peso molecular: 539.64

Ref: 4Z-N-066019

Nintedanib

CAS: 656247-17-5

Nintedanib

Pureza: ≥98%

Peso molecular: 539.62g/mol

Ref: 54-BUP16962

Nintedanib

Producto controlado

CAS: 656247-17-5

Fórmula: C₃₁H₃₃N₅O₄

Forma y color: Neat

Peso molecular: 539.62

Ref: 86-MM3704.01

Nintedanib

CAS: 656247-17-5

Fórmula: C₃₁H₃₃N₅O₄

Pureza: >95.0%(T)(HPLC)

Forma y color: White to Yellow to Yellow green powder to crystal

Peso molecular: 539.64

Ref: 3B-N1313

Nintedanib

CAS: 656247-17-5

Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/

Fórmula: C₃₁H₃₃N₅O₄

Pureza: 98% - 99.92%

Forma y color: Solid

Peso molecular: 539.62

Ref: TM-T1777

Nintedanib (free base)

CAS: 656247-17-5

Fórmula: C₃₁H₃₃N₅O₄

Pureza: ≥ 99.0%

Forma y color: White to yellow or beige solid

Peso molecular: 539.62

Ref: 7W-GW5215

Intedanib

Producto controlado

CAS: 656247-17-5

Applications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Fórmula: C₃₁H₃₃N₅O₄

Forma y color: Neat

Peso molecular: 539.62

Ref: TR-I666650

Nintedanib

CAS: 656247-17-5

Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis . Nintedanib Bio-X is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1).

Fórmula: C₃₁H₃₃O₄N₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 539.63 g/mol

Ref: 3D-FM34144

Nintedanib - Bio-X ™

CAS: 656247-17-5

Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis. Nintedanib is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1). 
Nintedanib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₃₁H₃₃O₄N₅

Pureza: (%) Min. 95%

Forma y color: Yellow To Green-Yellow Solid

Peso molecular: 539.63 g/mol

Ref: 3D-BN164249