CAS 66085-59-4

Nimodipina

Descripción:

Nimodipina es un bloqueador de canales de calcio dihidropiridínico utilizado principalmente en el campo médico por su capacidad para mejorar el flujo sanguíneo cerebral. Está indicado especialmente para la prevención de déficits neurológicos isquémicos tras una hemorragia subaracnoidea. El compuesto se caracteriza por su acción selectiva sobre los vasos sanguíneos cerebrales, lo que conduce a la vasodilatación sin afectar significativamente la presión arterial sistémica. Nimodipina tiene una lipofilia relativamente alta, lo que facilita su penetración a través de la barrera hematoencefálica. Su estructura química incluye un anillo de 1,4-dihidropiridina, que es esencial para su actividad farmacológica. La sustancia se administra típicamente por vía oral o intravenosa, y su farmacocinética implica una rápida absorción y metabolismo, con una vida media relativamente corta. Los efectos secundarios comunes pueden incluir dolor de cabeza, hipotensión y trastornos gastrointestinales. Debido a su acción específica y perfil de efectos secundarios, Nimodipina es un agente terapéutico valioso en neurología, particularmente en el manejo de condiciones relacionadas con el vasoespasmo cerebral.

Fórmula: C₂₁H₂₆N₂O₇

InChI: InChI=1/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,17,19H,9-10H2,1-5H3/t17?,19-/m0/s1

Clave InChI: InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Sinónimos:

• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester
• 2-Methoxyethyl Propan-2-Yl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-O-(2-Methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Admon
• BAY-e 9736
• Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
• Nemotan
• Nimodipin
• Nimodipine AP
• Nimodipino
• Nimotop
• Periplum
• Nimodipine
• inedicarboxylate
• 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER
• isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid
• Bay e 9736, Admon, Nimotop, periplum
• NIMODIPINE EPN(CRM STANDARD)
• NIMODIPINE MM(CRM STANDARD)
• NIMODIPINE BP STANDARD(CRM STANDARD)
• 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid
• NIMODIPINE CALCIUM CHANNEL ANTAG
• ethoxyethyl1-methylethylester

Nimodipine, 98+%

CAS: 66085-59-4

Potent L-type calcium channel antagonist

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 98+%

Forma y color: Powder

Peso molecular: 418.45

Ref: 02-J61287

Nimodipine

CAS: 66085-59-4

Forma y color: Neat

Ref: 61-FOR0416.00

Nimodipine

CAS: 66085-59-4

Nimodipine

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 100.0%

Forma y color: Yellow Solid

Peso molecular: 418.174

Ref: 47-651

NIMODIPINE CRS

CAS: 66085-59-4

NIMODIPINE CRS

Fórmula: C₂₁H₂₆N₂O₇

Peso molecular: 418.4403

Ref: 41-N0850000

Nimodipine

CAS: 66085-59-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Yellow Crystalline Powder

Peso molecular: 418.174

Ref: 45-1463858

Nimodipine

CAS: 66085-59-4

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 99.64% - 99.79%

Forma y color: Solid

Peso molecular: 418.44

Ref: TM-T0343

Nimodipine

CAS: 66085-59-4

Nimodipine

Pureza: 98%

Peso molecular: 418.44g/mol

Ref: 54-OR1030244

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: Off-white to yellow powder

Peso molecular: 418.44

Ref: 7W-GP2955

Nimodipine

CAS: 66085-59-4

Nimodipine

Pureza: ≥98%

Peso molecular: 418.44g/mol

Ref: 54-BUP14874

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Yellow Solid

Peso molecular: 418.45

Ref: 4Z-N-151

Nimodipine

Producto controlado

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Neat

Peso molecular: 418.44

Ref: 86-MM0416.00

Nimodipine 100 µg/mL in Acetonitrile

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Single Solution

Peso molecular: 418.44

Ref: 04-A15526800AL-100

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Neat

Peso molecular: 418.44

Ref: 04-C15526800

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 418.45

Ref: 3B-N0896

Nimodipine

CAS: 66085-59-4

Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.
References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Fórmula: C₂₁H₂₆N₂O₇

Forma y color: Neat

Peso molecular: 418.44

Ref: TR-N478200

Nimodipine

CAS: 66085-59-4

Nimodipine is a medication that belongs to the group of calcium channel blockers. It is used as a treatment for cerebral vasospasm, subarachnoid hemorrhage, and hypertensive emergencies. Nimodipine inhibits calcium influx into cells by blocking voltage-sensitive L-type calcium channels in smooth muscle cells. This medication has been shown to be effective when used with other drugs in the treatment of vasospasm or after aneurysm surgery. Nimodipine has also been shown to increase blood flow and improve brain function in patients with head injuries. The effects of nimodipine on cerebral blood flow have been demonstrated using whole-cell recordings from brain slices.

Fórmula: C₂₁H₂₆N₂O₇

Pureza: Min. 98 Area-%

Forma y color: Slightly Yellow Powder

Peso molecular: 418.44 g/mol

Ref: 3D-II57946

Nimodipine

CAS: 66085-59-4

M02160 - Nimodipine

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 95%

Forma y color: Solid

Peso molecular: 418.446

Ref: 10-M02160