CAS 66309-69-1

Clorhidrato de cefotiam

Descripción:

Clorhidrato de cefotiam es un antibiótico cefalosporínico de amplio espectro, utilizado principalmente para el tratamiento de diversas infecciones bacterianas. Se caracteriza por su capacidad para inhibir la síntesis de la pared celular bacteriana, que es un mecanismo crucial para su actividad antibacteriana. El compuesto se administra típicamente por inyección y es efectivo contra bacterias Gram-positivas y Gram-negativas. Clorhidrato de cefotiam es conocido por su estabilidad en presencia de beta-lactamasas, enzimas producidas por algunas bacterias que confieren resistencia a otros antibióticos. La sustancia es soluble en agua, lo que facilita su uso en entornos clínicos. Su farmacocinética incluye una rápida absorción y distribución en los tejidos del cuerpo, con una vida media relativamente corta, lo que requiere múltiples dosis para efectos terapéuticos sostenidos. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales y reacciones alérgicas, similares a otros antibióticos. Al igual que con cualquier antibiótico, se recomienda realizar pruebas de susceptibilidad adecuadas para garantizar su efectividad contra patógenos específicos. En general, Clorhidrato de cefotiam es una opción valiosa en el arsenal de antibióticos, particularmente para infecciones donde otros tratamientos pueden fallar.

Fórmula: C₁₈H₂₃N₉O₄S₃·2ClH

InChI: InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1

Clave InChI: InChIKey=BWRRTAXZCKVRON-DGPOFWGLSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4N(CCN(C)C)N=NN4)[H].Cl

Sinónimos:

• (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
• (6R-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, hydrochloride (1:2), (6R,7R)-
• Abbott 48999
• Cefotiam Dihydrichloride
• Cefotiam dihydrochloride
• Cefotiam.2HCl(Cefotiam hydrochloride)
• Ceradon
• Halospor
• Pansporin
• Pansporine
• Spizef
• Sporidyn

Cefotiam dihydrochloride

CAS: 66309-69-1

A broad spectrum antibiotic

Fórmula: C₁₈H₂₃N₉O₄S₃•HCl

Peso molecular: 562.09

Ref: 02-J66529

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-

CAS: 66309-69-1

Fórmula: C₁₈H₂₅Cl₂N₉O₄S₃

Pureza: 96%

Forma y color: Solid

Peso molecular: 598.5500

Ref: IN-DA00IBL5

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride is a third-gen cephalosporin that disrupts bacterial cell wall synthesis by inhibiting PBPs.

Fórmula: C₁₈H₂₃N₉O₄S₃·2HCl

Pureza: 98.23% - 99.98%

Forma y color: Solid

Peso molecular: 598.60

Ref: TM-T1616

Cefotiam hydrochloride

CAS: 66309-69-1

Cefotiam hydrochloride

Pureza: ≥98%

Peso molecular: 598.6g/mol

Ref: 54-BUP14507

Cefotiam Dihydrochloride

CAS: 66309-69-1

Cefotiam Dihydrochloride

Pureza: 98%

Peso molecular: 598.54g/mol

Ref: 54-OR1030485

Cefotiam DiHCl

CAS: 66309-69-1

Fórmula: C₁₈H₂₃N₉O₄S₃·2HCl

Forma y color: Off-White Solid

Peso molecular: 525.63 2*36.46

Ref: 4Z-C-10302

Cefotiam dihydrochloride hydrate

CAS: 66309-69-1

Fórmula: C₁₈H₂₃N₉O₄S₃·2HCl·xH₂O

Pureza: ≥ 98.0%

Forma y color: White, off-white to tan or yellow powder

Peso molecular: 598.55 (anhydrous)

Ref: 7W-GL6662

Cefotiam Hydrochloride RS

CAS: 66309-69-1

Forma y color: White To Pale Yellow-White

Ref: 2K-7000460021

Cefotiam Dihydrochloride

CAS: 66309-69-1

Applications Cephalosporin Antibiotic.
References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

Fórmula: C₁₈H₂₃N₉O₄S₃HCl

Forma y color: White To Light Yellow

Peso molecular: 598.55

Ref: TR-C243005

Cefotiam dihydrochloride

CAS: 66309-69-1

Cefotiam dihydrochloride is a semisynthetic antibiotic that belongs to the class of cephalosporin antibiotics. It inhibits bacterial growth by binding to penicillin-binding proteins and blocking cell wall synthesis. Cefotiam has been shown to be effective against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, and Clostridium perfringens. This drug is used in the treatment of infectious diseases caused by Gram-positive bacteria, including meningitis, endocarditis, osteomyelitis, and peritonitis. The intravenous injection of cefotiam has been shown to be safe and well tolerated in adults with septicemia or bacteremia. Cefotiam is excreted unchanged in the urine.

Fórmula: C₁₈H₂₅Cl₂N₉O₄S₃

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 598.55 g/mol

Ref: 3D-FC19863

Cefotiam hydrochloride

CAS: 66309-69-1

Pureza: 98%

Peso molecular: 598.54

Ref: 10-F979609

Cefotiam Dihydrochloride-13C, 15N2

Producto controlado

CAS: 61622-34-2, 66309-69-1

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Fórmula: C₁₇CH₂₃N₇N₂O₄S₃•2x(HCl)

Forma y color: Neat

Peso molecular: 601.5295

Ref: TR-C243007

Cefotiam Hydrochloride (DISCONTINUED)

CAS: 66309-69-1

Antibiotics nesoi

Fórmula: C₁₈H₂₃N₉O₄S₃·2ClH

Forma y color: Crystals

Peso molecular: 597.05687

Ref: 45-1098005