CAS 67814-76-0

D-Estreptamina, O-6-amino-6-desoxi-α-D-glucopiranosil-(1→4)-O-[3-desoxi-4-C-metil-3-(metilamino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-amino-2-hidroxi-1-oxopropil]-2-desoxi-, sulfato (1:?)

Descripción:

D-Estreptamina, O-6-amino-6-desoxi-α-D-glucopiranosil-(1→4)-O-[3-desoxi-4-C-metil-3-(metilamino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-amino-2-hidroxi-1-oxopropil]-2-desoxi-, sulfato (1:?) es un antibiótico aminoglucósido glicosilado complejo. Se caracteriza por su estructura intrincada, que incluye múltiples moieties de azúcar y un componente de aminoácido, contribuyendo a su actividad biológica. La presencia de grupos sulfato mejora su solubilidad y estabilidad en sistemas biológicos. Este compuesto exhibe propiedades antibacterianas, dirigiéndose principalmente a los ribosomas bacterianos para inhibir la síntesis de proteínas, lo que lo hace efectivo contra una variedad de bacterias Gram-negativas. Sus características estructurales únicas, incluidos los enlaces glicosídicos específicos y los grupos funcionales, son cruciales para su interacción con los objetivos bacterianos. Además, la estereoquímica del compuesto juega un papel significativo en su perfil farmacológico. Al igual que muchos aminoglucósidos, puede tener efectos secundarios potenciales, incluida la nefrotoxicidad y la ototoxicidad, lo que requiere una cuidadosa consideración en las aplicaciones terapéuticas. En general, la D-estreptamina representa una clase significativa de antibióticos con una importante relevancia clínica.

Fórmula: C₂₂H₄₃N₅O₁₂·xH₂O₄S

InChI: InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1

Clave InChI: InChIKey=DDXRHRXGIWOVDQ-MGAUJLSLSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Sinónimos:

• (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Exacin
• Isepacin
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Isepamicin sulfate

Isepamicin Sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₅N₅O₁₆S

Pureza: 98%

Forma y color: Solid

Peso molecular: 667.6816

Ref: IN-DA01DQ46

Isepamicin Sulfate

CAS: 67814-76-0

Isepamicin Sulfate

Pureza: 99%, ≥670μg/mg

Peso molecular: 667.68g/mol

Ref: 54-OR1025300

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate

Pureza: ≥98%

Peso molecular: 667.68g/mol

Ref: 54-BUP06503

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate (sch21420), an aminoglycoside, targets 30S ribosomal unit, effective against type I 6-acetyltransferase strains.

Fórmula: C₂₂H₄₃N₅O₁₂·SH₂O₄

Pureza: 99.31% - 99.91%

Forma y color: Solid

Peso molecular: 667.68

Ref: TM-T6549

Isepamicin Sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₃N₅O₁₂·H₂SO₄

Peso molecular: 569.61 98.08

Ref: 4Z-I-157001

Isepamicin sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₃N₅O₁₂

Pureza: ≥ 670μg/mg

Forma y color: White to off-white powder

Peso molecular: 569.60

Ref: 7W-GA5158

Isepamicin Sulfate

CAS: 67814-76-0

Stability Hygroscopic
Applications Isepamicin sulfate (CAS# 67814-76-0) is an aminoglycoside antibiotic with excellent capability of transference from venous blood to bone marrow blood.
References Li, G.; et al.: Zhongguo Xiandai Yixue Zazhi, 17, 1507 (2007).

Fórmula: C₂₂H₄₃N₅O₁₂•H₂O₄S

Forma y color: Off-White

Peso molecular: 569.609808

Ref: TR-I927013

Isepamicin sulphate

CAS: 67814-76-0

Isepamicin Sulphate is an aminoglycoside antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used for treating infections caused by gram-negative bacteria.

Fórmula: C₂₂H₄₃N₅O₁₂•H₂SO₄

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 667.68 g/mol

Ref: 3D-FI65046

Isepamicin sulfate - 70%

CAS: 67814-76-0

Isepamicin sulfate - 70% is a semi-synthetic aminoglycoside antibiotic, which is derived from naturally occurring antibiotic compounds through chemical modifications. Its mode of action involves binding to the bacterial 30S ribosomal subunit, disrupting protein synthesis and consequently causing bacterial cell death. This mechanism of action is typical of aminoglycosides, characterized by their bactericidal properties against a broad spectrum of Gram-negative bacteria, with some efficacy against certain Gram-positive bacterial strains.

Fórmula: C₂₂H₄₅N₅O₁₆S

Pureza: Min. 95%

Forma y color: White/Off-White Solid

Peso molecular: 667.68 g/mol

Ref: 3D-FI163230