CAS 68-42-8

Tetrahidrocorticosterona

Descripción:

Tetrahidrocorticosterona (THC) es una hormona esteroide que pertenece a la clase de corticosteroides, que se producen en la corteza adrenal. Está involucrada principalmente en la regulación de varios procesos fisiológicos, incluyendo el metabolismo, la respuesta inmune y la respuesta al estrés. THC se caracteriza por su estructura, que incluye un núcleo esteroide con cuatro anillos de carbono fusionados. Es un compuesto relativamente hidrofóbico, lo que influye en su solubilidad y transporte en sistemas biológicos. La hormona exhibe propiedades antiinflamatorias y juega un papel en la respuesta del cuerpo al estrés al modular el metabolismo de la glucosa y el equilibrio de electrolitos. En términos de su actividad biológica, THC puede unirse a receptores específicos, influyendo en la expresión génica y las funciones celulares. Es importante en la investigación relacionada con la función adrenal y tiene implicaciones en la comprensión de varios trastornos relacionados con la insuficiencia adrenal y condiciones relacionadas con el estrés. Debido a su naturaleza hormonal, la regulación de los niveles de THC en el cuerpo es crucial para mantener la homeostasis.

Fórmula: C₂₁H₃₄O₄

InChI: InChI=1/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13-,14+,15+,16-,17+,19-,20+,21+/m1/s1

Clave InChI: InChIKey=RHQQHZQUAMFINJ-DTDWNVJFSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)[C@@H](C(CO)=O)CC4)[H])(CC[C@@]1(C[C@H](O)CC2)[H])[H])[H]

Sinónimos:

• (3Alpha,5Beta,11Beta)-3,11,21-Trihydroxypregnan-20-One
• (3α,5β,11β)-3,11,21-Trihydroxypregnan-20-one
• 3alpha,11beta,21-Trihydroxy-5beta-pregnan-20-one
• 3α,11β,21-Trihydroxy-5β-pregnan-20-one
• 3α,5β-Tetrahydrocorticosterone
• 5β-Pregnan-20-one, 3α,11β,21-trihydroxy-
• 5β-Pregnane-3α,11β,21-triol-20-one
• Corticosterone, tetrahydro-
• Pregnan-20-one, 3,11,21-trihydroxy-, (3α,5β,11β)-
• Tetrahydrocorticosterone
• (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN 2HCL
• Tetrahydrocorticosterone (solution)
• 5BETA-PREGNANE-3A,11BETA,21-TRIOL-20-ONE
• 3-ALPHA,11-BETA,21-TRIHYDROXY-5-BETA-PREGNAN-20-ONE
• 5-BETA-PREGNANE-3-ALPHA,11-BETA,21-TRIOL-20-ONE
• THB
• 1-[(3R,5R,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-ethanone
• 1-[(3R,5R,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxyethanone
• TETRAHYDRO COMPOUND 'B'
• TH 'B'

Tetrahydrocorticosterone

CAS: 68-42-8

Fórmula: C₂₁H₃₄O₄

Pureza: 97%

Forma y color: Solid

Peso molecular: 350.4923

Ref: IN-DA00FA58

5β-Pregnan-3α, 11β,21-triol-20-one-17α,21,21-d3 (Tetrahydrocorticosterone)

CAS: 68-42-8

Pureza: 98 atom % D

Peso molecular: 353.51

Ref: 3U-D7804

Tetrahydrocorticosterone

CAS: 68-42-8

Fórmula: C₂₁H₃₄O₄

Peso molecular: 350.50

Ref: 4Z-C-10412

Tetrahydrocorticosterone

CAS: 68-42-8

Applications Tetrahydrocorticosterone is a urinary steroid metabolite that decreases in postmenopausal women with osteoporosis. Tetrahydrocorticosterone is a potential biomarker of pathol. adrenal function.
References Poor, V., et. al.: Chromatographia, 60, S165 (2004); Kotlowska, A., et. al.: J. Chromatogr. B, 879, 359 (2011)

Fórmula: C₂₁H₃₄O₄

Forma y color: Neat

Peso molecular: 350.49

Ref: TR-T293160

Tetrahydrocorticosterone

Producto controlado

CAS: 68-42-8

Tetrahydrocorticosterone is a hormone produced by the adrenal glands that regulates the metabolism of carbohydrates, proteins, and fats. It also has other biological effects such as inhibition of cyclase activity and production of malonic acid. Tetrahydrocorticosterone can be used to measure cortisol concentration in blood serum or urine samples. The detection sensitivity for this compound is 5-10 ng/mL. This hormone is found in high concentrations in adrenocortical carcinoma, which may be due to its ability to inhibit cyclase activity. Tetrahydrocorticosterone has been shown to have an effect on glomerular filtration rate and body mass index, which may be due to its ability to promote protein synthesis.

Fórmula: C₂₁H₃₄O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 350.49 g/mol

Ref: 3D-FT65181

Tetrahydrocorticosterone

CAS: 68-42-8

THB is a glucocorticoid with anti-inflammatory effects, acting on GC receptors; its isomers vary between male and female rat brains.

Fórmula: C₂₁H₃₄O₄

Forma y color: Solid

Peso molecular: 350.49

Ref: TM-T68877