CAS 680-31-9

Hexametilfosforamida

Descripción:

Hexametilfosforamida (HMPA) es un compuesto organofosforado caracterizado por su fórmula química C6H18N3OP. Es un líquido incoloro e inodoro que es altamente polar y exhibe una excelente solubilidad en agua y muchos disolventes orgánicos. HMPA es conocido por su capacidad para actuar como un fuerte disolvente aprotico polar, lo que lo hace valioso en varias reacciones químicas, particularmente en sustituciones nucleofílicas y química de polímeros. Su estructura presenta un átomo de fósforo unido a tres grupos metilo y un grupo fosforamidato, lo que contribuye a sus propiedades únicas. HMPA también es reconocido por su capacidad para estabilizar intermediarios reactivos, como carbocationes y carbaniones, debido a sus fuertes capacidades de formación de enlaces de hidrógeno. Sin embargo, es importante señalar que HMPA se considera tóxico y presenta riesgos para la salud al ser expuesto, lo que requiere un manejo cuidadoso y medidas de seguridad adecuadas en entornos de laboratorio. Sus aplicaciones se extienden a la síntesis orgánica, donde sirve como disolvente y reactivo, así como en la producción de varios compuestos químicos.

Fórmula: C₆H₁₈N₃OP

InChI: InChI=1/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3

Clave InChI: InChIKey=GNOIPBMMFNIUFM-UHFFFAOYSA-N

SMILES: P(N(C)C)(N(C)C)(N(C)C)=O

Sinónimos:

• Eastman Inhibitor HPT
• Ent 50,882
• HPT
• Hempa
• Hexametapol
• Hexamethylorthophosphoric triamide
• Hexamethylphosphamide
• Hexamethylphosphoramde (HMPA)
• Hexamethylphosphoramide
• Hexamethylphosphoric Triamide
• Hexamethylphosphoric acid triamide
• Hexamethylphosphorotriamide
• Hexamethylphosphorsaeuretriamid
• Hexamethylphosporic triamide
• Hexamethyltriamidophosphate
• Hexametiltriamida Fosforica
• Hmpa
• Hmpt
• Hmpta
• Light Stabilizer HPT
• N,N',N''-Hexamethylphosphoramide
• N,N,N′,N′,N′′,N′′-Hexamethylphosphoric triamide
• Nsc 113131
• Nsc 7967
• Phosphoric acid hexamethyltriamide
• Phosphoric hexamethyltriamide
• Phosphoric triamide, N,N,N',N',N'',N''-hexamethyl-
• Phosphoric tris(dimethylamide)
• Phosphoryl hexamethyltriamide
• Triamide hexamethylphosphorique
• Tris(dimethylamino)phosphine oxide
• [Bis(dimethylamino)phosphoryl]dimethylamine
• Hexamethyl Phosphoramide
• Phosphoric triamide, hexamethyl-
• hexamethyl
• AURORA KA-1674
• ent50,882
• PHOSPHORIC ACID TRIS(DIMETHYLAMIDE)
• eastmaninhibitorhpt
• ent50882

Hexamethylphosphoramide

CAS: 680-31-9

Pureza: 98.0%

Forma y color: Liquid

Peso molecular: 179.20399475097656

Ref: 10-F075260

Hexamethylphosphoric Triamide

CAS: 680-31-9

Fórmula: C₆H₁₈N₃OP

Pureza: >98.0%(GC)(T)

Forma y color: Colorless to Light yellow to Light orange clear liquid

Peso molecular: 179.20

Ref: 3B-H0095

Hexamethylphosphoramide

CAS: 680-31-9

Fórmula: C₆H₁₈N₃OP

Pureza: 98%

Forma y color: Liquid

Peso molecular: 179.2004

Ref: IN-DA0034ZW

Hexamethylphosphamide

Producto controlado

CAS: 680-31-9

Fórmula: C₆H₁₈N₃OP

Forma y color: Neat

Peso molecular: 179.20

Ref: 04-C14194700

Hexamethylphosphoramide

CAS: 680-31-9

Hexamethylphosphoramide

Fórmula: C₆H₁₈N₃OP

Pureza: 99%

Forma y color: colourless liquid

Peso molecular: 179.20g/mol

Ref: 54-OR13709

Hexamethyltriamidophosphate

Producto controlado

CAS: 680-31-9

Stability Very Hygroscopic
Applications Hexamethyltriamidophosphate is a known carcinogen, metabolized by CYP450 2A. Also a mutagenic agent, causing genotoxicity with increased exposure.
References Thornton-M. et al.: Toxicol. App. Pharm., 142, 22 (1997); Doherty, A. et al.: Mutagenesis., 27, 533 (2012);

Fórmula: C₆H₁₈N₃OP

Forma y color: Neat

Peso molecular: 179.20

Ref: TR-H294325

Hexamethylphosphoramide

Producto controlado

CAS: 680-31-9

Hexamethylphosphoramide (HMP) is a glycol ether that is used as a solvent in the manufacture of plastics and rubber, and as a fire extinguishing agent. It has been shown to have an effect on the gland cells of rats, causing an increase in the number of cells and an increase in the size of their nuclei. HMP also has a thermal expansion coefficient that is higher than that of water. The protonation potential for HMP is greater than that for water, which may be due to the intramolecular hydrogen bond between the two methyl groups. Chronic oral exposure to hexamethylphosphoramide can cause squamous cell carcinoma in rats. Titration calorimetry shows that hexamethylphosphoramide reacts with trifluoroacetic acid according to a reaction mechanism involving transfer reactions. Hexamethylphosphoramide has been shown to have effects on autoimmune diseases such as Crohn's disease and multiple sclerosis

Fórmula: C₆H₁₈N₃OP

Pureza: Min. 98%

Forma y color: Clear Colourless To Pale Yellow Liquid

Peso molecular: 179.2 g/mol

Ref: 3D-FH04180