CAS 6890-08-0

2-hidroxiisoquinolina-1,3(2H,4H)-diona

Descripción:

2-hidroxiisoquinolina-1,3(2H,4H)-diona, también conocido como 2-hidroxi-1,3-dihidroisoquinolina-1,3-diona, es un compuesto orgánico caracterizado por su estructura de isoquinolina, que presenta un sistema bicíclico fusionado. Este compuesto contiene un grupo hidroxilo (-OH) y dos grupos carbonilo (C=O) dentro de su marco molecular, lo que contribuye a su reactividad y potencial actividad biológica. Típicamente aparece como un sólido a temperatura ambiente y es soluble en disolventes polares, reflejando su capacidad para participar en enlaces de hidrógeno debido a la presencia del grupo hidroxilo. El compuesto es de interés en química medicinal y puede exhibir diversas propiedades farmacológicas, incluyendo actividades antimicrobianas y antiinflamatorias. Su estructura permite interacciones potenciales con objetivos biológicos, convirtiéndolo en un tema de investigación en el desarrollo de fármacos. Al igual que con muchos compuestos orgánicos, el manejo debe hacerse con cuidado, considerando los datos de seguridad y los peligros potenciales asociados con su uso.

Fórmula: C₉H₇NO₃

InChI: InChI=1/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2

SMILES: c1ccc2c(c1)CC(=O)N(C2=O)O

Sinónimos:

• 1,3(2H,4H)-Isoquinolinedione, 2-hydroxy-
• 2-Hydroxyisoquinoline-1,3(2H,4H)-dione

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Fórmula: C₉H₇NO₃

Pureza: 95%

Forma y color: Solid

Peso molecular: 177.1568

Ref: IN-DA00FDF9

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Pureza: 95%

Ref: 54-OR1041975

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) acts as an inhibitor of both HIV-1 integrase (IN) and HIV-1 reverse transcriptase ribonuclease H (RT RNase H), exhibiting IC50 values of 6.32 µM and 5.9 µM, respectively.

Fórmula: C₉H₇NO₃

Peso molecular: 177.16

Ref: TM-T88443

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Producto controlado

CAS: 6890-08-0

Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.
References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),

Fórmula: C₉H₇NO₃

Forma y color: Neat

Peso molecular: 177.16

Ref: TR-H939800

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

2-Hydroxyisoquinoline-1,3(2H,4H)-dione (2HIQ) is a potent anti-viral agent that has been shown to inhibit the replication of viruses in cell cultures. 2HIQ inhibits viral replication by binding to the enzyme reverse transcriptase and inhibiting its ability to synthesize DNA from RNA. This drug also has inhibitory properties against human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 2HIQ binds to the active site of the enzyme HIV reverse transcriptase, which is a key enzyme in viral replication. It also binds to HCV NS5B polymerase, which is an essential protein in HCV replication. These interactions lead to inhibition of viral replication and thus prevention of disease progression.

Fórmula: C₉H₇NO₃

Pureza: Min. 95%

Forma y color: Off-White To Brown Solid

Peso molecular: 177.16 g/mol

Ref: 3D-FH24374

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Fórmula: C₉H₇NO₃

Pureza: 95%

Forma y color: Solid

Peso molecular: 177.159

Ref: 10-F244686