CAS 69056-38-8

Dihidrocloruro de sapropterina

Descripción:

Dihidrocloruro de sapropterina es una forma sintética del cofactor natural tetrahidrobiopterina (BH4), utilizado principalmente en el tratamiento de la fenilcetonuria (PKU), un trastorno metabólico caracterizado por la incapacidad de metabolizar la fenilalanina. Este compuesto actúa como un chaperón farmacológico, mejorando la actividad de la fenilalanina hidroxilasa, la enzima responsable de convertir la fenilalanina en tirosina. Dihidrocloruro de sapropterina es un polvo cristalino blanco a blanco amarillento que es soluble en agua, lo que lo hace adecuado para la administración oral. Su fórmula química refleja su forma de sal dihidrocloruro, que contribuye a su estabilidad y solubilidad. La sustancia generalmente es bien tolerada, con efectos secundarios comunes que incluyen dolor de cabeza, trastornos gastrointestinales y reacciones alérgicas. Como agente terapéutico, desempeña un papel crucial en el manejo de los niveles de fenilalanina en sangre, previniendo así las complicaciones neurológicas asociadas con la PKU. Su uso se monitorea típicamente a través de análisis de sangre regulares para asegurar la eficacia y seguridad en los pacientes.

Fórmula: C₉H₁₅N₅O₃·2ClH

InChI: InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1

Clave InChI: InChIKey=RKSUYBCOVNCALL-NTVURLEBSA-N

SMILES: O=C1C2=C(NC[C@]([C@H]([C@H](C)O)O)(N2)[H])NC(N)=N1.Cl

Sinónimos:

• (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride
• (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
• (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride
• (6R)-Tetrahydrobiopterin hydrochloride
• (6β)-5,6,7,8-Tetrahydro-<span class="text-smallcaps">L</span>-biopterin dihydrochloride
• 2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
• 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]-
• 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)-
• 4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-
• 4(3H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-
• BioMarin T 1401
• Biopten
• Kuvan
• Sapropterin HCl
• Sapropterin hydrochloride
• Shiratori SN 0588
• Sun 0588
• T1401
• Unii-Rg277Lf5B3
• Sapropterin dihydrochloride

(6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl

CAS: 69056-38-8

Fórmula: C₉H₁₇Cl₂N₅O₃

Pureza: 95%

Forma y color: Solid

Peso molecular: 314.1690

Ref: IN-DA005LS6

Sapropterin dihydrochloride

CAS: 69056-38-8

Sapropterin dihydrochloride

Pureza: ≥98%

Peso molecular: 314.17g/mol

Ref: 54-BUP14430

Sapropterin DiHCl (Dehydro Sepiapterin DiHCl)

CAS: 69056-38-8

Fórmula: C₉H₁₅N₅O₃·2HCl

Forma y color: White To Off-White Solid

Peso molecular: 241.25 2*36.46

Ref: 4Z-S-311

Sapropterin dihydrochloride

CAS: 69056-38-8

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.

Fórmula: C₉H₁₇Cl₂N₅O₃

Pureza: 98% - 99.88%

Forma y color: White Crystalline Solid

Peso molecular: 314.17

Ref: TM-T7117

(6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride

CAS: 69056-38-8

Stability Hygroscopic
Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
References Levy, Harvey L., et al.: Lancet,  370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)

Fórmula: C₉H₁₅N₅O₃·2(HCl)

Forma y color: White To Off-White

Peso molecular: 241.25 + 2(36.46)

Ref: TR-T795613

Sapropterin Dihydrochloride

CAS: 69056-38-8

Fórmula: C₉H₁₅N₅O₃(HCl)

Peso molecular: 241.3 : 2(36.5)

Ref: ST-EA-CP-S25013

Sapropterin dihydrochloride

CAS: 69056-38-8

Cofactor for nitric oxide synthetase and Phe, Tyr and Trp hydroxylases

Fórmula: C₉H₁₅N₅O₃·2HCl

Pureza: Min. 97 Area-%

Forma y color: White Powder

Peso molecular: 314.17 g/mol

Ref: 3D-FT04562

(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride

CAS: 69056-38-8

Fórmula: C₉H₁₇Cl₂N₅O₃

Pureza: 95%

Peso molecular: 314.17

Ref: 10-F216001