CAS 69075-47-4

Citosina, 2'-desoxi-5-etinil-

Descripción:

Citosina, 2'-desoxi-5-etinil- (CAS 69075-47-4) es un nucleósido modificado que presenta un grupo etinilo en la posición 5 del anillo de pirimidina, que es una modificación característica que mejora sus propiedades para diversas aplicaciones, particularmente en biología molecular y química medicinal. Este compuesto es un derivado de la deoxicitidina, donde la sustitución etinilo puede influir en su interacción con ácidos nucleicos y su incorporación en ARN o ADN. La presencia del grupo etinilo también puede mejorar la estabilidad y la afinidad de unión del nucleósido, haciéndolo útil en el desarrollo de agentes antivirales y anticancerígenos. Además, puede exhibir propiedades espectroscópicas únicas debido al enlace triple, que se puede explotar en diversas técnicas analíticas. En general, 2'-deoxi-5-etinilo-citosina sirve como una herramienta valiosa en contextos de investigación y terapéuticos, particularmente en el estudio de la dinámica de ácidos nucleicos y el diseño de análogos de nucleósidos.

Fórmula: C₁₁H₁₃N₃O₄

5-Ethynyl-2'-deoxycytidine

CAS: 69075-47-4

Fórmula: C₁₁H₁₃N₃O₄

Pureza: >98.0%(N)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 251.24

Ref: 3B-E1093

Cytidine, 2'-deoxy-5-ethynyl-

CAS: 69075-47-4

Fórmula: C₁₁H₁₃N₃O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 251.2386

Ref: IN-DA006DIS

5-Ethynyl-2'-Deoxycytidine

CAS: 69075-47-4

5-Ethynyl-2'-Deoxycytidine

Pureza: 98%

Peso molecular: 251.24g/mol

Ref: 54-OR1011871

2'-Deoxy-5-ethynylcytidine

CAS: 69075-47-4

2'-Deoxy-5-ethynylcytidine is a cytosine analog that inhibits the synthesis of viral DNA and the production of new virus particles. It has been shown to inhibit herpes simplex virus type-1 (HSV-1) in cell cultures, as well as other viruses such as vaccinia and adenovirus. 2'-Deoxy-5-ethynylcytidine has also been shown to have anti-cancer properties in animal studies. This drug binds to the cellular nucleic acid, preventing transcription of viral genes into messenger RNA and preventing protein synthesis, thereby inhibiting replication of the virus. 2'-Deoxy-5-ethynylcytidine also inhibits the synthesis of cellular DNA by binding to nuclear DNA.
2'-Deoxy-5-ethynylcytidine is an analog of cytosine that binds to dna polymerase and prevents it from adding on new nucleotides, which blocks viral reproduction.

Fórmula: C₁₁H₁₃N₃O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 251.24 g/mol

Ref: 3D-ND161709

5′-Ethynyl-2′-deoxycytidine

CAS: 69075-47-4

Pureza: 98%

Peso molecular: 251.242

Ref: 10-F842638

5-Ethynyl-2’-deoxycytidine

Producto controlado

CAS: 69075-47-4

Fórmula: C₁₁H₁₃N₃O₄

Forma y color: Neat

Peso molecular: 251.239

Ref: TR-E932170

5'-Ethynyl-2'-deoxycytidine

CAS: 69075-47-4

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

Fórmula: C₁₁H₁₃N₃O₄

Forma y color: Solid

Peso molecular: 251.242

Ref: TM-T84380