CAS 7059-24-7

Cromomicina A3

Descripción:

Cromomicina A3 es un antibiótico antraciclínico producido por la bacteria *Streptomyces griseus*. Se conoce principalmente por su uso en el tratamiento del cáncer debido a su capacidad para intercalar el ADN, inhibiendo así la síntesis de ADN y ARN. Este compuesto exhibe un color amarillo brillante y es soluble en agua, lo que facilita su uso en diversas aplicaciones biológicas. Cromomicina A3 tiene una fórmula molecular que refleja su estructura compleja, con múltiples anillos aromáticos y moieties de azúcar, que contribuyen a su actividad biológica. Su mecanismo de acción implica la unión a regiones ricas en GC del ADN, lo que lleva a la interrupción de los procesos celulares en células que se dividen rápidamente, lo que es característico de muchos agentes anticancerígenos. Además, se ha estudiado Cromomicina A3 por su posible uso en biología molecular como una sonda fluorescente para la detección de ADN. Sin embargo, su uso clínico es limitado debido a la posible toxicidad y efectos secundarios, lo que requiere una cuidadosa consideración en las aplicaciones terapéuticas. En general, Cromomicina A3 representa un compuesto significativo en el campo de la química medicinal y la investigación del cáncer.

Fórmula: C₅₇H₈₂O₂₆

InChI: InChI=1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1

Clave InChI: InChIKey=ZYVSOIYQKUDENJ-WKSBCEQHSA-N

SMILES: O=C1C=2C(C[C@@]([C@@H](C([C@H]([C@@H](C)O)O)=O)OC)([C@@H]1O[C@H]3C[C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O5)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[H])=CC=6C(C2O)=C(O)C(C)=C(O[C@H]7C[C@@H](O[C@@H]8C[C@@H](O)[C@@H](OC)[C@@H](C)O8)[C@@H](OC(C)=O)[C@@H](C)O7)C6

Sinónimos:

• (1S)-1-C-[(2S,3S)-7-[[4-O-Acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-<span class="text-smallcaps">D</smallcap>-lyxo-hexopyranosyl)-β-<smallcap>D</smallcap>-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-<smallcap>D</span>-threo-2-pentulose
• (1S)-1-C-[(2S,3S)-7-{[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-alpha-D-lyxo-hexopyranosyl)-beta-D-lyxo-hexopyranosyl]oxy}-3-{[4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-5-deoxy-1-O-methyl-D-xylulose
• 3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D
• <span class="text-smallcaps">D</smallcap>-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-<smallcap>D</smallcap>-lyxo-hexopyranosyl)-β-<smallcap>D</smallcap>-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-<smallcap>D</span>-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-, (1S)-
• Aburamycin B
• Antibiotic 69895 A
• Antibiotic B 599
• Antibiotic from Streptomyces griseus
• CMA³
• Ccris 2755
• Chromomycin A(sub 3)
• Chromomycin A₃
• Nsc 58514
• Olivomycin D, 3^D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)-7-methyl-
• Olivomycin D, 3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methyl- (9CI)
• Olivomycin D, 3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabinohexopyranosyl)-7-methyl-
• Olivomycin D, 3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methyl-
• Toyomycin
• (1S)-1-C-[(2S,3S)-7-[[4-O-Acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-D-threo-2-pentulose
• D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-, (1S)-
• Chromomycin A3

Chromomycin A3, 97%

CAS: 7059-24-7

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate G-C box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting tr

Fórmula: C₅₇H₈₂O₂₆

Pureza: 97%

Forma y color: Yellow, Powder or crystals or crystalline powder

Peso molecular: 1183.26

Ref: 02-J62927

Chromomycin A3

CAS: 7059-24-7

Fórmula: C₅₇H₈₂O₂₆

Pureza: ≥ 98%

Forma y color: Yellow powder

Peso molecular: 1183.30

Ref: 7W-GA6463

Chromomycin A3

CAS: 7059-24-7

Chromomycin A3 is an antibioti,inhibits DNA replication and transcription; a fluorescent DNA stain and assay; anticancer Hodgkin's,melanomas, and breast cancer.

Fórmula: C₅₇H₈₂O₂₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 1183.24

Ref: TM-T10810

Chromomycin A3

CAS: 7059-24-7

Chromomycin A3

Fórmula: C₅₇H₈₂O₂₆

Pureza: By hplc: 99.39% (Typical Value in Batch COA)

Forma y color: yellow powder

Peso molecular: 1,183.25g/mol

Ref: 54-BIC1009

Chromomycin A3 from streptomyces griseus

CAS: 7059-24-7

Chromomycin A3 (CMA3) is a cytotoxic antibiotic that is produced by Streptomyces griseus. CMA3 inhibits DNA synthesis and provides protection against bacterial infection, as well as cancer cells. It binds to the D-loop region of duplex DNA, which prevents the progression of polymerase chain reactions. CMA3 has been shown to be effective in inhibiting growth of gram-positive bacteria and gram-negative bacteria, as well as many species of fungi. The use of CMA3 may be complicated by its toxicity to animal cells, so it should only be used in combination with other antibiotics because it can reduce the toxicity of other drugs.

Fórmula: C₅₇H₈₂O₂₆

Pureza: Min. 95 Area-%

Forma y color: Powder

Peso molecular: 1,183.25 g/mol

Ref: 3D-FC41668