CAS 71610-00-9

Cefalomannina

Descripción:

Cefalomannina es un compuesto natural clasificado como un tipo de alcaloide, específicamente derivado de la especie de planta *Cephalotaxus*, comúnmente conocida como tejo de ciruela. Este compuesto se caracteriza por su compleja estructura molecular, que incluye múltiples anillos y grupos funcionales que contribuyen a su actividad biológica. Cefalomannina exhibe notables propiedades farmacológicas, incluyendo efectos potenciales anti-cancerígenos e inmunomoduladores, lo que lo hace de interés en la química medicinal y la investigación farmacéutica. Su mecanismo de acción a menudo implica la interacción con vías celulares, influyendo en la proliferación celular y la apoptosis. El compuesto se estudia típicamente en el contexto de sus aplicaciones terapéuticas, particularmente en oncología. Además, Cefalomannina es soluble en disolventes orgánicos, lo que es relevante para su extracción y formulación en diversas aplicaciones. Al igual que muchos productos naturales, el estudio de Cefalomannina también incluye investigaciones sobre su biosíntesis y los roles ecológicos que puede desempeñar dentro de su especie de planta nativa. En general, Cefalomannina representa un área significativa de interés para los investigadores que exploran compuestos naturales con posibles beneficios para la salud.

Fórmula: C₄₅H₅₃NO₁₄

InChI: InChI=1/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

Clave InChI: InChIKey=DBXFAPJCZABTDR-WBYYIXQISA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(/C(=C/C)/C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinónimos:

• (2alpha,3xi,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-[(2-methylbut-2-enoyl)amino]-3-phenylpropanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, alpha-hydroxy-beta-(((2E)-2-methyl-1-oxo-2-butenyl)amino)-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
• Benzenepropanoic acid, alpha-hydroxy-beta-((2-methyl-1-oxo-2-butenyl)amino)-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(aR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
• Benzenepropanoic acid, α-hydroxy-β-[(2-methyl-1-oxo-2-butenyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-butenyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Nsc 318735
• Taxol B
• Cephalomannine
• Cephalomannine, 98%, from Taxus chinensis (Pilg.) Rehder
• CEPHALOMANNINE (TAXOL B)
• 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, ...
• Paclitaxel Impurity 2（Paclitaxel EP Impurity B）
• CEPHALOMANNINE(P)
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...
• Paclitaxel Related CoMpound A
• CephaloMannine, froM Taxus chinensis
• Paclitaxel EP Impurity B
• BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-
• BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-
• Cephalomannine, >99%
• paclitaxel iMpurity I
• Paclitaxel Impurity Ⅰ:Cephalomannine
• N-Debenzoyl-N-tigloylpaclitaxel
• N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)
• Paclitaxel Related Compound A (Cephalomannine)
• 3′-N-(trans-2-methyl-2-butenoyl)-3′-N-debenzoylpaclitaxel
• N-Debenzoyl-N-tigloylpaclitaxel (Ce
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1
• Cephalomannine 71610-00-9
• -[(2-methyl-1-oxo-2-butenyl)amino]-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,[2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoicacid, α-hydroxy-β
• Cephalomannine USP/EP/BP
• Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)

Paclitaxel Related Compound A (Cephalomannine)

CAS: 71610-00-9

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₄₅H₅₃NO₁₄

Forma y color: White Off-White Powder

Peso molecular: 831.34661

Ref: 45-1491343

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.90

Ref: 7W-GA4112

Cephalomannine (Paclitaxel USP Related Compound A)

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Forma y color: White To Off-White Solid

Peso molecular: 831.91

Ref: 4Z-C-11901

Cephalomannine

CAS: 71610-00-9

Cephalomannine

Pureza: ≥98%

Peso molecular: 831.9g/mol

Ref: 54-BUP00025

N-Debenzoyl-N-tigloylpaclitaxel (Cephalomannine)

CAS: 71610-00-9

Forma y color: Neat

Ref: 86-MM1489.02

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Pureza: 95%~99%

Peso molecular: 831.912

Ref: BP-BP0332

Cephalomannine

CAS: 71610-00-9

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Fórmula: C₄₅H₅₃NO₁₄

Pureza: 98.77% - 99.75%

Forma y color: Solid

Peso molecular: 831.9

Ref: TM-T2217

Paclitaxel EP Impurity B

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.90

Ref: ST-EA-CP-P36145

Cephalomannine

Producto controlado

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Forma y color: White

Peso molecular: 831.90

Ref: TR-C258500

Cephalomannine

CAS: 71610-00-9

Pureza: 98%

Peso molecular: 831.912

Ref: 10-F987648

Cephalomannine

CAS: 71610-00-9

Cephalomannine is a diterpenoid alkaloid product, which is derived from the needles of the Taxus species, commonly known as yew trees. It is structurally similar to paclitaxel (Taxol), a well-known chemotherapeutic agent. The mode of action of cephalomannine involves binding to the β-subunit of tubulin, thereby promoting the polymerization of tubulin into stable microtubules while simultaneously inhibiting their depolymerization. This stabilization of the microtubule network disrupts the normal process of cell division, effectively arresting cell mitosis, which leads to cell death.

Fórmula: C₄₅H₅₃NO₁₄

Pureza: Min. 95%

Peso molecular: 831.9 g/mol

Ref: 3D-FC19896

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.91

Ref: ST-EA-CP-C548004

Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

CAS: 71610-00-9

Fórmula: C₃₇H₄₃NO₁₀

Forma y color: Solid

Peso molecular: 661.7380

Ref: IN-DA0038H4