CAS 71827-03-7

Ivermectina B1a

Descripción:

Ivermectina B1a, con el número CAS 71827-03-7, es un lactona macrocíclica derivada de la fermentación de la bacteria del suelo Streptomyces avermitilis. Es un potente agente antiparasitario utilizado principalmente en medicina veterinaria y tiene aplicaciones en medicina humana para tratar diversas infecciones parasitarias. Ivermectina B1a exhibe un amplio espectro de actividad contra nematodos y ectoparásitos, incluidos los piojos y la sarna. El compuesto funciona al unirse a los canales de cloro activados por glutamato, lo que lleva a un aumento de la permeabilidad de la membrana celular a los iones de cloro, resultando en parálisis y muerte de los parásitos. La ivermectina generalmente es bien tolerada, con un perfil de seguridad favorable, aunque puede causar efectos secundarios en algunas personas, particularmente a dosis más altas. La sustancia se administra típicamente por vía oral o tópica, dependiendo del tipo de infección que se esté tratando. Su eficacia y seguridad la han convertido en un componente crítico en las iniciativas de salud global, particularmente en la lucha contra las enfermedades tropicales desatendidas.

Fórmula: C₄₈H₇₄O₁₄

InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

Clave InChI: InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES: O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]

Sinónimos:

• (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside
• 22,23-Dihydro-5-O-demethylavermectin A1a
• 22,23-Dihydroavermectin B(1)a
• 22,23-Dihydroavermectin B1a
• 22,23-Dihydroavermectin B_1a
• 5-O-Demethyl-22,23-dihydroavermectin A_1a
• Avermectin A1a, 22,23-dihydro-5-O-demethyl-
• Avermectin A_1a, 5-O-demethyl-22,23-dihydro-
• Brn 4643153
• Dihydroavermectin B1a
• Dihydroavermectin B_1a
• Ivermectin B1a
• Ivermectin B_1a
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-91Y2202Ouw
• Avermectin A1a, 5-O-demethyl-22,23-dihydro-
• 5-O-Demethyl-22,23-dihydroavermectin A1a

Ivermectin B1a-d2

CAS: 71827-03-7

Fórmula: C₄₈H₇₂D₂O₁₄

Forma y color: White To Off-White Solid

Peso molecular: 877.12

Ref: 4Z-I-077008

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a

Pureza: ≥98%

Peso molecular: 875.09g/mol

Ref: 54-BUP00618

Ivermectin B1a

CAS: 71827-03-7

Fórmula: C₄₈H₇₄O₁₄

Forma y color: White To Off-White Solid

Peso molecular: 875.11

Ref: 4Z-I-077016

Ivermectine B1a

CAS: 71827-03-7

Forma y color: Neat

Ref: 04-CA14488005

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Fórmula: C₄₈H₇₄O₁₄

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 875.09

Ref: TM-T21727

Ivermectin B1a-D2

Producto controlado

CAS: 71827-03-7

Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Fórmula: C₄₈H₇₂D₂O₁₄

Forma y color: Neat

Peso molecular: 877.11

Ref: TR-I940817

Ivermectin B1a (>85%)

Producto controlado

CAS: 71827-03-7

Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Fórmula: C₄₈H₇₄O₁₄

Pureza: >85%

Forma y color: Neat

Peso molecular: 875.09

Ref: TR-I940815

Ivermectin B1a-D2

CAS: 71827-03-7

Ivermectin is a broad-spectrum antiparasitic agent that is used to treat onchocerciasis and other infectious diseases. It binds selectively to gamma-aminobutyric acid (GABA) receptors in the central nervous system and inhibits the release of neurotransmitters, thereby inhibiting the inflammatory response. Ivermectin has been shown to be safe for use in humans and has a long half-life that allows for once-weekly administration. This drug also has pharmacokinetic properties that are similar among different species and clinical studies have shown no significant differences between human and animal models. Ivermectin is applied topically as an ointment or cream or orally as tablets or capsules, depending on the condition being treated.

Fórmula: C₄₈H₇₂D₂O₁₄

Pureza: Min. 95%

Peso molecular: 877.11 g/mol

Ref: 3D-WCA82703

Ivermectin 2-epimer

CAS: 71827-03-7

Fórmula: C₄₈H₇₄O₁₄

Peso molecular: 875.11

Ref: ST-EA-CP-I18017