CAS 71989-33-8

N-(9-Fluorenilmetoxicarbonil)-O-terc-butilserina

Descripción:

N-(9-Fluorenilmetoxicarbonil)-O-terc-butilserina, comúnmente conocido como Fmoc-O-t-Bu-Ser, es un derivado de aminoácido protegido ampliamente utilizado en la síntesis de péptidos. Este compuesto presenta un grupo 9-fluorenilmetoxicarbonilo (Fmoc), que sirve como un grupo protector para la funcionalidad amino, permitiendo reacciones selectivas durante el ensamblaje de péptidos. El grupo tert-butilo en la cadena lateral de serina proporciona una hindrance estérica adicional, mejorando la estabilidad de la molécula y previniendo reacciones prematuras. Fmoc-O-t-Bu-Ser se utiliza típicamente en la síntesis de péptidos en fase sólida, donde su estabilidad en condiciones básicas facilita la adición secuencial de aminoácidos. El compuesto es generalmente soluble en disolventes orgánicos como el diclorometano y el dimetilformamida, lo que lo hace adecuado para varios protocolos sintéticos. Su estructura permite la fácil eliminación del grupo Fmoc en condiciones básicas suaves, lo que permite el acoplamiento subsiguiente de otros aminoácidos. En general, Fmoc-O-t-Bu-Ser es un bloque de construcción valioso en el campo de la química de péptidos, contribuyendo a la síntesis eficiente de péptidos y proteínas complejas.

Fórmula: C₂₂H₂₅NO₅

InChI: InChI=1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1

Clave InChI: InChIKey=REITVGIIZHFVGU-IBGZPJMESA-N

SMILES: C(OC(N[C@@H](COC(C)(C)C)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Sinónimos:

• (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid
• (2S)-3-(tert-Butoxy)-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid
• (2S)-3-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate
• <span class="text-smallcaps">L</span>-Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• Fmoc-L-Ser(tBu)-OH
• Fmoc-Ser(OtBu)-OH
• Fmoc-Ser(tBu)-OH
• N-(9-Fluorenylmethoxycarbonyl)-O-Tert-Butyl-L-Serine
• N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
• N-Fmoc-O-tert-butyl-L-serine
• O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-serine
• O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)serine
• O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine
• O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]serine
• O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine
• L-Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• N-ALPHA-FMOC-O-T-BUTYL-L-SERINE
• N-9-FLUORENYLMETHYLOXYCARBONYL-O-T-BUTYL-L-SERINE
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-L-SERINE
• 9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-SERINE
• N-9-FLUORENYLMETHYLOXYCARBONYL-O-TERT-BUTYL-L-SERINE
• FMOC-O-TERT-BUTYL-L-SERINE
• FMOC-SER(BUT)
• N-(9-FLUORENYL METHOXY CARBONYL)-O-TERT-BUTYL-L-SERINE
• N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-L-SERINE
• FMOC-O-T-BUTYL-L-SERINE
• FMOC-L-SERINE(O-T-BUTYL)
• FMOC-L-SER(T-BU)
• N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TERT-BUTYL-L-SERINE
• FMOC-SER(BUT)-OH
• FMOC-L-SER(O-T-BUTYL)
• FMOC-SER(TBU)
• FMOC-SERINE(TBU)-OH

O-tert-Butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine

CAS: 71989-33-8

Fórmula: C₂₂H₂₅NO₅

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 383.44

Ref: 3B-B3168

N-Fmoc-O-tert-butyl-L-serine, 97%

CAS: 71989-33-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₂₂H₂₅NO₅

Pureza: 97%

Peso molecular: 383.44

Ref: 02-H59422

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

M03382 - Fmoc-Ser(tBu)-OH

Fórmula: C₂₂H₂₅NO₅

Pureza: 98%

Forma y color: Powder or Crystalline Powder or Solid

Peso molecular: 383.444

Ref: 10-M03382

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

To minimize the concomitant racemization, couplings of Fmoc-Ser(OtBu)-OH with uronium/aminium reagents should be performed in the presence of collidine in place of DIEA.

Fórmula: C₂₂H₂₅NO₅

Pureza: 99.9%

Forma y color: White

Peso molecular: 383.44

Ref: 01-4003086

Fmoc-O-Tert-Butyl-L-Serine

CAS: 71989-33-8

Fórmula: C₂₂H₂₅NO₅

Pureza: 96%

Forma y color: Solid

Peso molecular: 383.4376

Ref: IN-DA0034Y6

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Fórmula: C₂₂H₂₅NO₅

Pureza: ≥ 99.0%

Forma y color: White powder

Peso molecular: 383.44

Ref: 7W-GM0224

FMOC-L-Ser(tBu)-OH

CAS: 71989-33-8

FMOC-L-Ser(tBu)-OH

Fórmula: C₂₂H₂₅NO₅

Pureza: 98%

Forma y color: white powder

Peso molecular: 383.44g/mol

Ref: 54-OR54566

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Fmoc-Ser(tBu)-OH is a tert-butyl-protected serine for peptide assembly, chemical biology, and biomaterial synthesis with enhanced stability and selectivity.

Fórmula: C₂₂H₂₅NO₅

Pureza: 99.97%

Forma y color: Solid

Peso molecular: 383.44

Ref: TM-T67570

FMOC-O-Tert-Butyl-L-Serine (FMOC-Ser(tBu)-OH) extrapure, 99%

CAS: 71989-33-8

Fórmula: C₂₂H₂₅NO₅

Pureza: min. 99%

Forma y color: White to off-white, Powder

Peso molecular: 383.44

Ref: SR-13334

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Fmoc-Ser(tBu)-OH is a synthetic peptide that is used in the synthesis of peptides and proteins. It is synthesized by using a stepwise procedure, which involves the use of morpholine as an organic base to deprotonate the carboxylic acid group and then reacting it with trifluoroacetic acid (TFA) to form the corresponding chloroformate ester. The amide bond is formed by reaction with ammonia or an amine. Finally, it can be reacted with hydrochloric acid to form the corresponding hydrochloride salt, which is insoluble in water. Impurities such as thionyl chloride and chloroformate can be removed by washing with methylene chloride or chloroform, respectively. Fmoc-Ser(tBu)-OH has been shown to be selective for the formation of hydrophobic bonds between amino acids and is not reactive toward other side chains on the protein.

Fórmula: C₂₂H₂₅NO₅

Pureza: Min. 98.0 Area-%

Peso molecular: 383.45 g/mol

Ref: 3D-FLS-1733-PI

Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Fmoc-Ser(tBu)-OH is a synthetic amino acid that is used in the synthesis of degarelix acetate, an amide ester of the vasodilator, prostaglandin F2α. Degarelix acetate binds to the fibrinogen receptor on the surface of cells and inhibits platelet aggregation. This drug has been shown to be effective in treating prostate cancer by inhibiting epidermal growth factor receptor signaling. It also has immune modulating effects by binding to monoclonal antibodies and altering antibody responses. Fmoc-Ser(tBu)-OH is synthesized from the amino acid serine and t-butyl alcohol, which are combined with trifluoroacetic acid (TFA) and hydroxyl group. The resulting product is then reacted with dansyl chloride or benzoyl chloride (BzCl), which cleaves off one carboxylic acid group from serine, forming an

Fórmula: C₂₂H₂₅NO₅

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 383.44 g/mol

Ref: 3D-FF15777