CAS 72063-39-9

Espinosina

Descripción:

Espinosina, con el número CAS 72063-39-9, es un compuesto natural derivado principalmente de la especie vegetal *Ziziphus jujuba*, comúnmente conocida como jujube. Pertenece a la clase de los flavonoides y se reconoce por sus potenciales propiedades farmacológicas. Espinosina se caracteriza por su estructura química única, que incluye un esqueleto de flavona, contribuyendo a su bioactividad. Este compuesto ha despertado interés en el campo de la medicina herbal debido a sus efectos ansiolíticos, sedantes y neuroprotectores reportados. Además, Espinosina exhibe propiedades antioxidantes, que pueden ayudar a mitigar el estrés oxidativo en sistemas biológicos. Su perfil de solubilidad sugiere que es más soluble en disolventes orgánicos que en agua, lo que puede influir en su biodisponibilidad y aplicaciones terapéuticas. La investigación sobre Espinosina continúa explorando sus mecanismos de acción y beneficios potenciales en el tratamiento de diversas condiciones de salud, particularmente aquellas relacionadas con la ansiedad y los trastornos del sueño. En general, Espinosina representa un área significativa de interés en la química de productos naturales y la farmacología.

Fórmula: C₂₈H₃₂O₁₅

InChI: InChI=1S/C28H32O15/c1-39-14-7-15-18(12(32)6-13(40-15)10-2-4-11(31)5-3-10)22(35)19(14)26-27(24(37)21(34)16(8-29)41-26)43-28-25(38)23(36)20(33)17(9-30)42-28/h2-7,16-17,20-21,23-31,33-38H,8-9H2,1H3/t16-,17-,20-,21-,23+,24+,25-,26+,27-,28+/m1/s1

Clave InChI: InChIKey=VGGSULWDCMWZPO-ODEMIOGVSA-N

SMILES: O(C)C1=C(C(O)=C2C(=C1)OC(=CC2=O)C3=CC=C(O)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4

Sinónimos:

• (1S)-1,5-Anhydro-2-O-beta-D-glucopyranosyl-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol
• 4H-1-Benzopyran-4-one, 6-(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 4H-1-Benzopyran-4-one, 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 6-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• D-glucitol, 1,5-anhydro-2-O-beta-D-glucopyranosyl-1-C-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-
• Flavoayamenin
• Spinosin
• Swertisin 2′′-O-glucoside
• 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 6-(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-

Spinosin

CAS: 72063-39-9

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Fórmula: C₂₈H₃₂O₁₅

Forma y color: Yellow Powder

Peso molecular: 608.17412

Ref: 45-1618717

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Pureza: 95%

Forma y color: Solid

Peso molecular: 608.5447

Ref: IN-DA00FBG1

Spinosin

CAS: 72063-39-9

Spinosin

Pureza: ≥98%

Peso molecular: 608.54g/mol

Ref: 54-BUP00112

Spinosin

CAS: 72063-39-9

Spinosin

Pureza: 95%

Peso molecular: 608.54g/mol

Ref: 54-OR1024110

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Peso molecular: 608.55

Ref: 7W-GY0454

Spinosin

CAS: 72063-39-9

Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.

Fórmula: C₂₈H₃₂O₁₅

Pureza: 95%~99%

Peso molecular: 608.549

Ref: BP-BP1336

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Pureza: >95.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 608.55

Ref: 3B-P2887

Spinosin

CAS: 72063-39-9

1.

Fórmula: C₂₈H₃₂O₁₅

Pureza: 98.16% - 99.75%

Forma y color: Solid

Peso molecular: 608.54

Ref: TM-T6S2227

Spinosin

CAS: 72063-39-9

Natural glycoside

Fórmula: C₂₈H₃₂O₁₅

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 608.55

Ref: 5G-83284

Spinosin

Producto controlado

CAS: 72063-39-9

Applications Spinosin is a C-glycoside flavonoid extracted from Zizhiphi Spinozae, improved pentobarbital-induced sleep.
References Wang, Li. et al.: Pharm. Biochem. Behav., 90, 399 (2008);

Fórmula: C₂₈H₃₂O₁₅

Forma y color: Neat

Peso molecular: 608.54

Ref: TR-S681950

Spinosin

CAS: 72063-39-9

Spinosin is a natural product that belongs to the group of pyrrolizidine alkaloids. It has been shown to have physiological function as it can inhibit the 5-HT1A receptor and thereby regulate neurotransmitter release. Spinosin also has anti-inflammatory effects and can be used in the treatment of skin disorders, such as psoriasis. In vitro studies have shown that spinosin is a substrate for P-gp and interacts with other drugs by inhibiting their absorption in the gut and liver. Spinosin has been found to bind to monoclonal antibodies, which may be due to its structural similarity to chinese herb, a known antigenic protein. This leads to increased uptake of spinosin into cells and thus makes it an analytical method for measuring spinosin in biological samples. Spinosin activates p38mapk which then causes the phosphorylation of ERK1/2, leading to receptor binding and activation of downstream signaling pathways.

Fórmula: C₂₈H₃₂O₁₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 608.54 g/mol

Ref: 3D-FS65586