CAS 73030-71-4

Atractilenólido III

Descripción:

Atractilenólido III es un compuesto bioactivo derivado principalmente de las raíces de la hierba medicinal china tradicional Atractylodes macrocephala. Pertenece a la clase de los sesquiterpenos y se caracteriza por su estructura química única, que contribuye a sus diversas propiedades farmacológicas. Este compuesto es conocido por sus potenciales efectos antiinflamatorios, anticancerígenos e inmunomoduladores, lo que lo hace de interés tanto en la medicina tradicional como en la investigación farmacológica moderna. Atractilenólido III exhibe una variedad de actividades biológicas, incluida la capacidad de inhibir ciertas enzimas y modular vías de señalización, lo que puede contribuir a sus efectos terapéuticos. Además, se ha estudiado por sus efectos protectores contra el estrés oxidativo y su papel en la mejora de las respuestas inmunitarias. El compuesto se extrae y purifica típicamente para fines de investigación, y su perfil de seguridad se considera generalmente favorable, aunque se necesitan más estudios para comprender completamente sus mecanismos de acción y aplicaciones potenciales en entornos clínicos.

Fórmula: C₁₅H₂₀O₃

InChI: InChI=1/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

Clave InChI: InChIKey=FBMORZZOJSDNRQ-GLQYFDAESA-N

SMILES: O[C@@]12C(C[C@@]3([C@@](C)(C1)CCCC3=C)[H])=C(C)C(=O)O2

Sinónimos:

• (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9a-hydroxy-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
• 8β-Hydroxyasterolide
• Atractylenolide III
• Atractylenolide β
• Codonolactone
• Naphtho(2,3-b)furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
• Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, [4aS-(4aα,8aβ,9aβ)]-
• Atractylenolide III, BR
• (4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzoxol-2-one
• Atractylenolide beta
• 8-HYDROXYASTEROLIDE
• ICodonolactone
• Atracylenolide III
• ATRACTYLENOLIDE
• (4aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9aβ-hydroxy-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• Atractylenolide III (ICodonolactone
• Atractylenolide III USP/EP/BP

Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-,(4aS,8aR,9aS)-

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 248.3175

Ref: IN-DA00ICC9

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III

Pureza: ≥98%

Peso molecular: 248.32g/mol

Ref: 54-BUP10043

Atractylenolide III

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Peso molecular: 248.32

Ref: 7W-GL2829

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III is the major bioactive component of Atractylodes lancea, it inhibits histamine release, suppresses activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB in stimulated HMC-1 cells, and suppresses the activation of caspase-1 and the expression of receptor interacting protein-2, suggests that atractylenolide III may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

Fórmula: C₁₅H₂₀O₃

Pureza: 95%~99%

Forma y color: White cryst.

Peso molecular: 248.322

Ref: BP-BP0216

Atractylenolide III

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 248.32

Ref: 3B-A3609

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III could treat cognitive issues and lung cancer by modulating apoptosis factors.

Fórmula: C₁₅H₂₀O₃

Pureza: 99.53% - 99.82%

Forma y color: Solid

Peso molecular: 248.32

Ref: TM-T3902

Atractylenolide iii

CAS: 73030-71-4

Lactone

Fórmula: C₁₅H₂₀O₃

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 248.32

Ref: 5G-80359

ATRACTYLENOLIDE III

CAS: 73030-71-4

Pureza: 98%

Peso molecular: 248.3220062

Ref: 10-F809712

AtractylenolideIII

CAS: 73030-71-4

Atractylenolide III is a sesquiterpene lactone, which is derived from the rhizomes of Atractylodes macrocephala, a plant commonly used in traditional Chinese medicine. With its origin in botanical sources, the compound is notable for its diverse biological activities and mechanisms of action. Atractylenolide III exerts its effects primarily through the modulation of various signaling pathways, including anti-inflammatory, anti-cancer, and immunomodulatory pathways. It inhibits the production of pro-inflammatory cytokines and regulates the expression of key signaling proteins, thus impacting cellular processes such as proliferation, apoptosis, and differentiation. The compound shows promise in the treatment of conditions like cancer, inflammation, and immune disorders. Researchers continue to explore its potential benefits, seeking to elucidate the molecular mechanisms underlying its therapeutic effects and to optimize its application in various biomedical fields.

Pureza: Min. 95%

Ref: 3D-FA73865