CAS 73232-52-7

Bromuro de metilnaltrexona

Descripción:

Bromuro de metilnaltrexona es un derivado de amonio cuaternario de la naltrexona, utilizado principalmente como medicamento para tratar el estreñimiento inducido por opioides, particularmente en pacientes con enfermedades avanzadas. Funciona como un antagonista del receptor mu-opioide de acción periférica, lo que significa que bloquea los efectos de los opioides en el tracto gastrointestinal sin afectar el alivio del dolor en el sistema nervioso central. Esta acción selectiva ayuda a aliviar el estreñimiento sin revertir la analgesia. Bromuro de metilnaltrexona se administra típicamente mediante inyección subcutánea y tiene un inicio de acción rápido. Su estructura química incluye un grupo metilo unido al átomo de nitrógeno de la columna vertebral de la naltrexona, lo que mejora su solubilidad y propiedades farmacocinéticas. La sustancia es generalmente bien tolerada, con efectos secundarios comunes que incluyen dolor abdominal, diarrea y náuseas. Debido a su mecanismo de acción específico, es particularmente beneficiosa para los pacientes que están en terapia crónica con opioides y experimentan estreñimiento como efecto secundario. Bromuro de metilnaltrexona se clasifica como un medicamento de prescripción y debe usarse bajo supervisión médica.

Fórmula: C₂₁H₂₆NO₄·Br

InChI: InChI=1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1

Clave InChI: InChIKey=IFGIYSGOEZJNBE-KNLJMPJLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2([N+](CC6CC6)(C)CC4)[H].[Br-]

Sinónimos:

• (17RS)-17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-17-methyl-6- oxomorphinanium bromide
• (5Alpha)-17-(Cyclopropylmethyl)-3,14-Dihydroxy-17-Methyl-4,5-Epoxymorphinan-17-Ium-6-One Bromide
• Methylnaltrexone bromide [USAN]
• Moa-728
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide (1:1), (5α)-
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide, (5alpha)-
• Mrz 2663
• Mrz 2663Br
• N-Cyclopropylmethyl-noroxymorphone methobromide
• N-Methylnaltrexone bromide
• Naltrexone methobromide
• Naltrexone methyl bromide
• Relistor
• Unii-Rfo6Il3D3M

Methylnaltrexone Bromide

CAS: 73232-52-7

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Fórmula: C₂₁H₂₆BrNO₄

Forma y color: White Off-White Powder

Peso molecular: 435.10452

Ref: 45-1430735

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide

Pureza: ≥98%

Peso molecular: 436.35g/mol

Ref: 54-BUP05752

Methyl Naltrexone-d3 Bromide (Mixture of Diastereomers)

CAS: 73232-52-7

Fórmula: C₂₁H₂₃D₃NO₄·Br

Peso molecular: 359.46 79.90

Ref: 4Z-N-0135

Methylnaltrexone Bromide

CAS: 73232-52-7

Fórmula: C₂₁H₂₆NO₄·Br

Peso molecular: 356.44 79.90

Ref: 4Z-N-0140

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists, acts to reverse the side effects of opioid drugs.

Fórmula: C₂₁H₂₆BrNO₄

Pureza: 99.02%

Forma y color: Solid

Peso molecular: 436.35

Ref: TM-T21422

N-Methyl Naltrexone-d3 Bromide

Producto controlado

CAS: 73232-52-7

Applications A labelled metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007),

Fórmula: C₂₁H₂₃D₃BrNO₄

Forma y color: Neat

Peso molecular: 439.36

Ref: TR-M320352

N-Methyl Naltrexone Bromide

Producto controlado

CAS: 73232-52-7

Stability Hygroscopic
Applications A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Fórmula: C₂₁H₂₆BrNO₄

Forma y color: Neat

Peso molecular: 436.35

Ref: TR-M320350

Methylnaltrexone Bromide

CAS: 73232-52-7

Fórmula: C₂₁H₂₆BrNO₄

Pureza: >95.0%(HPLC)(qNMR)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 436.35

Ref: 3B-M3504

N-Methyl naltrexone bromide

Producto controlado

CAS: 73232-52-7

N-Methyl naltrexone bromide is an opioid antagonist that binds to opioid receptors, preventing the binding of other opioid agonists. It has been shown to be effective in long-term treatment of chronic pain and may be used in combination with opioids for patients with hepatic impairment. The efficacy of N-methyl naltrexone bromide in treating constipation has not been established. This drug should not be used in patients with HIV infection because it may reduce the effectiveness of antiretroviral therapy. The pharmacokinetics and safety profile of this drug have been studied extensively, which showed no serious adverse effects. Histological analysis revealed that N-methyl naltrexone bromide did not affect epithelial mesenchymal cells or the intestinal villi.

Fórmula: C₂₁H₂₆BrNO₄

Pureza: Min. 95%

Peso molecular: 436.34 g/mol

Ref: 3D-FM25532