CAS 73449-07-7

2'-desoxi-2'-fluoroadenosina 5'-(trifosfato de tetrahidrógeno)

Descripción:

2'-desoxi-2'-fluoroadenosina 5'-(trifosfato de tetrahidrógeno), comúnmente conocido como dFATP, es un nucleótido modificado que juega un papel significativo en la investigación bioquímica, particularmente en estudios que involucran la síntesis de ADN y la actividad de la polimerasa. Este compuesto se caracteriza por la presencia de un átomo de flúor en la posición 2' del azúcar ribosa, lo que lo distingue del nucleótido natural trifosfato de desoxiadenosina (dATP). La sustitución de flúor puede influir en la estabilidad y reactividad del nucleótido, haciéndolo útil para investigar mecanismos enzimáticos y para aplicaciones en biología molecular. El dFATP se utiliza típicamente como sustrato en reacciones de polimerización de ADN, donde puede ser incorporado en hebras de ADN, permitiendo a los investigadores estudiar los efectos del flúor en la estructura y función del ADN. Además, su forma de trifosfato proporciona la energía necesaria para la incorporación en ácidos nucleicos. El compuesto se utiliza a menudo en diversos entornos experimentales, incluyendo el desarrollo de agentes antivirales y en el estudio de los procesos de replicación y reparación del ADN.

Fórmula: C₁₀H₁₅FN₅O₁₂P₃

InChI: InChI=1/C10H15FN5O12P3/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17H,1H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t4-,5-,7-,10-/m1/s1

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)F)O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O

2''-Deoxy-2''-fluoroadenosine-5''-triphosphate

CAS: 73449-07-7

Ref: 7W-GN8261

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate tetralithium salt

CAS: 73449-07-7

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate tetralithium salt (FdATP) is a competitive inhibitor of ATP. It inhibits the synthesis of RNA, DNA, and protein in cell culture at high concentrations. FdATP is also an analog of adenosine triphosphate (ATP), which is needed for cellular energy production. The competitive inhibition of ATP by FdATP prevents the formation of a phosphorylated enzyme that is required for the initiation of DNA synthesis. This can lead to cell death, as the cells cannot produce proteins required for growth and replication.

Fórmula: C₁₀H₁₁FN₅O₁₂P₃•Li₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 532.9 g/mol

Ref: 3D-ND15214

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate

CAS: 73449-07-7

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate is an analog of adenosine triphosphate (ATP). It inhibits the synthesis of RNA by binding to the ribonucleotide reductase enzyme. This inhibition leads to the inhibition of DNA synthesis, which in turn prevents cell division and/or causes cell death. The inhibitory effect of 2'-deoxy-2'-fluoroadenosine-5'-triphosphate on protein and DNA synthesis has been shown in vivo and in vitro using cell culture techniques. This compound inhibits topoisomerase II, a key enzyme in DNA replication, at high concentrations.

Fórmula: C₁₀H₁₅FNO₁₂P₃

Pureza: Min. 95%

Peso molecular: 509.18 g/mol

Ref: 3D-ND09532

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 73449-07-7

2'-Deoxy-2'-fluoroadenosine-5'-triphosphate lithium salt is an analog of ATP that has significant inhibitory effect on DNA polymerase. It inhibits the synthesis of RNA and protein by binding to the enzyme DNA gyrase. This drug is used in cell culture as a nucleotide analog to study how cells are affected by atp analogs. 2'-Deoxy-2'-fluoroadenosine-5'-triphosphate lithium salt is used at high concentrations in vitro, where it inhibits topoisomerases and prevents cell division.

Fórmula: C₁₀H₁₁FN₅O₁₂P₃·4Li

Pureza: Min. 95%

Peso molecular: 532.9 g/mol

Ref: 3D-ND46151