CAS 73554-84-4

tert-(Butiloxicarbonil)-L-valil-L-leucil-L-lisina-7-amino-4-metilcumarina

Descripción:

tert-(Butiloxicarbonil)-L-valil-L-leucil-L-lisina-7-amino-4-metilcumarina, comúnmente conocido como un derivado de péptido, se caracteriza por su estructura compleja que incluye un grupo protector de tert-butilo carbamato (Boc), que a menudo se utiliza en la síntesis de péptidos para proteger los grupos amino. La presencia de L-valina, L-leucina y L-lisina indica que es un péptido sintético compuesto por estos aminoácidos, contribuyendo a su actividad biológica y aplicaciones potenciales en el desarrollo de fármacos. El grupo de 7-amino-4-metilcumarina sirve como una etiqueta fluorescente, haciendo que este compuesto sea útil en ensayos bioquímicos y estudios que involucran interacciones de péptidos. Este compuesto es típicamente soluble en disolventes orgánicos y puede exhibir reactividad específica basada en sus grupos funcionales. Su estabilidad y reactividad pueden verse influenciadas por condiciones ambientales como el pH y la temperatura. En general, esta sustancia es significativa en los campos de la química medicinal y la bioquímica, particularmente en el desarrollo de terapias basadas en péptidos y sondas fluorescentes.

Fórmula: C₃₂H₄₉N₅O₇

InChI: InChI=1S/C32H49N5O7/c1-18(2)15-24(36-30(41)27(19(3)4)37-31(42)44-32(6,7)8)29(40)35-23(11-9-10-14-33)28(39)34-21-12-13-22-20(5)16-26(38)43-25(22)17-21/h12-13,16-19,23-24,27H,9-11,14-15,33H2,1-8H3,(H,34,39)(H,35,40)(H,36,41)(H,37,42)/t23-,24-,27-/m0/s1

Clave InChI: InChIKey=KVLPXRKIIFWZLM-DPZBCOQUSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)[C@@H](C)C)=O)CC(C)C)=O)CCCCN)=O)=CC2)OC(=O)C1

Sinónimos:

• 7: PN: WO2004106541 PAGE: 15 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Boc-Val-Leu-Lys-AMC
• Boc-Val-Leu-Lys-Amc Acetate
• N-(tert-butoxycarbonyl)-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide
• N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-<smallcap>L</span>-lysinamide
• tert-(Butyloxycarbonyl)-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</span>-lysine-7-amino-4-methylcoumarin
• tert-(Butyloxycarbonyl)-L-valyl-L-leucyl-L-lysine-7-amino-4-methylcoumarin
• N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
• L-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

A sensitive, fluorogenic, and specific substrate for the quantitative measurement of plasmin. Boc-VLK-AMC is also cleaved by acrosin from the ascidian Halocynthia roretzi, by porcine calpain isozymes I and II, and by papain.

Fórmula: C₃₂H₄₉N₅O₇

Pureza: 97.7%

Forma y color: White Lyophilisate

Peso molecular: 615.77

Ref: 01-4004467

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC is a research tool that has been shown to activate ion channels and increase the permeability of cell membranes. This compound also binds to receptors on cells, which may be due to its ability to bind with antibodies. Boc-Val-Leu-Lys-AMC has been used as an inhibitor in protein interactions and pharmacology studies, as well as for the study of ion channels in cell biology.

Fórmula: C₃₂H₄₉N₅O₇

Pureza: Min. 95%

Peso molecular: 615.76 g/mol

Ref: 3D-MVL-3104-V

Boc-Val-Leu-Lys-AMC acetate salt

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC acetate salt is a protease inhibitor that binds to the active site of trypsin and inhibits its proteolytic activity. It has been shown to protect neuronal cells from death caused by amyloid beta (Aβ) peptide. Boc-Val-Leu-Lys-AMC acetate salt also inhibits the secretion of proinflammatory cytokines and reduces the permeability of mitochondrial membranes in human neutrophils. This drug is stable in acidic environments, with a pH optimum of 2.0, but is sensitive to alkaline conditions with a pH optimum of 8.5. Boc-Val-Leu-Lys-AMC acetate salt has been shown to bind to casein, which may result in high values on sephadex g100 chromatography.

Fórmula: C₃₂H₄₉N₅O₇•C₂H₄O₂

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 675.81 g/mol

Ref: 3D-FB110487