CAS 74124-79-1

Carbonato de disuccinimidilo

Descripción:

Carbonato de disuccinimidilo (DSC) es un compuesto químico comúnmente utilizado como agente de entrecruzamiento en bioconjugación y química de proteínas. Se caracteriza por su capacidad para formar enlaces amida estables con aminas primarias, lo que lo hace particularmente útil para enlazar proteínas, péptidos y otras biomoléculas. El DSC es un sólido blanco a blanco sucio que es soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO) y el dimetilformamida (DMF), pero generalmente es insoluble en agua. Se conoce que el compuesto es estable en condiciones secas, pero puede hidrolizarse en presencia de humedad, lo que lleva a la liberación de succinimida. Su reactividad se atribuye al grupo funcional carbonato, que facilita la formación de enlaces covalentes con nucleófilos. Debido a su eficiencia y especificidad, el DSC se utiliza ampliamente en diversas aplicaciones, incluyendo el desarrollo de conjugados de anticuerpos y fármacos y en la modificación de biomoléculas para fines terapéuticos. El manejo y almacenamiento adecuados son esenciales, ya que el DSC puede ser sensible a la humedad y debe mantenerse en un ambiente fresco y seco.

Fórmula: C₉H₁₀N₂O₇

InChI: InChI=1/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2

Clave InChI: InChIKey=PFYXSUNOLOJMDX-UHFFFAOYSA-N

SMILES: O(C(ON1C(=O)CCC1=O)=O)N2C(=O)CCC2=O

Sinónimos:

• (Suo)2Co
• 1,1'-[Carbonylbis(Oxy)]Dipyrrolidine-2,5-Dione
• 1-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]oxy]-2,5-pyrrolidinedione
• 2,5-Pyrrolidinedione, 1,1′-[carbonylbis(oxy)]bis-
• Bis(2,5-dioxopyrrolidin-1-yl) carbonate
• Bis(N-succinimidyl) carbonate
• Bis(succinimidyl) carbonate
• Carbonic acid bis(2,5-dioxopyrrolidin-1-yl) ester
• Carbonic acid disuccinimidyl ester
• Carbonic acid, bis(2,5-dioxo-1-pyrrolidinyl) ester
• DI(N-succinimidyl) carbonate
• DI-(N,N'-succinimidyl) carbonate
• DSC
• Di(2,5-dioxopyrrolidin-1-yl) carbonate
• Di(succinimido) carbonate
• Disuccimidyl carbonate
• Disuccinimide carbonate
• Disuccinimidyl carbonate
• N,N′-Disuccinimido carbonate
• Su2O
• Timtec-Bb Sbb005976
• N,N′-Disuccinimidyl carbonate
• N-SUCCINIMIDYL CARBONATE
• LABOTEST-BB LT00847311
• N,N'-DisuccinimidylCarbonate98%
• N,N'-Disuccinimidyl
• DSCsee24500
• DSC [N,N'-DISUCCINIMIDYL CARBONATE]
• N,N'-Disuccinimidyl carbonate (DSC)

Di(N-succinimidyl) Carbonate

CAS: 74124-79-1

Fórmula: C₉H₈N₂O₇

Pureza: >98.0%(T)

Forma y color: White to Light gray to Light yellow powder to crystal

Peso molecular: 256.17

Ref: 3B-D1662

N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-Hydroxysuccinimide

CAS: 74124-79-1

N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected am

Fórmula: C₉H₈N₂O₇

Pureza: 85%

Forma y color: White to pale cream, Powder

Peso molecular: 256.17

Ref: 02-H26629

N,N'-Disuccinimidyl carbonate, Tech Grade

CAS: 74124-79-1

Fórmula: C₉H₈N₂O₇

Pureza: 95%

Forma y color: Solid

Peso molecular: 256.1690

Ref: IN-DA0035BN

N,N''-Disuccinimidyl carbonate (DSC)

CAS: 74124-79-1

Fórmula: C₉H₈N₂O₇

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 256.17

Ref: 7W-GE7435

Bis(2,5-dioxopyrrolidin-1-yl) carbonate

CAS: 74124-79-1

Bis(2,5-dioxopyrrolidin-1-yl) carbonate

Fórmula: C₉H₈N₂O₇

Pureza: 97%

Forma y color: white powder

Peso molecular: 256.16902g/mol

Ref: 54-OR40045

N,N’-Disuccinimidyl carbonate

CAS: 74124-79-1

Fórmula: C₉H₈N₂O₇

Pureza: 95.0%

Forma y color: Solid, Powder or Crystalline Powder or Solid

Peso molecular: 256.17

Ref: 10-F024500

N,N'-Disuccinimidyl carbonate

CAS: 74124-79-1

N,N'-Disuccinimidyl carbonate, also known as DSC, is a coupling reagent used in the synthesis of amides, urea derivatives and carbamates, and is also used as a phosgene analogue. DSC can be employed in presence of Hünig’s base in the synthesis of cyclic sulphonyl peptides containing an oxazolidin-2-ones formed from serine and threonine residues. DSC is utilised in the synthesis aza-glycinyl dipeptides to be used as building blocks for the synthesis of azapeptides. DSC is used to activate amides in order to covalently attach proteins onto solid supports through unnatural amino acids, such as post-translationally modified cysteines containing moieties suitable for click chemistry or Staudinger ligation. DSC also finds application in the post-functionalisation of poly(2-hydroxyethyl methacrylate) polymer brushes.

Fórmula: C₉H₈N₂O₇

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 256.17 g/mol

Ref: 3D-FD15692

Di-(N-Succinimidyl) Carbonate extrapure, 95%

CAS: 74124-79-1

Fórmula: C₉H₈N₂O₇

Pureza: min. 95%

Forma y color: White to off - white, Crystalline powder

Peso molecular: 256.17

Ref: SR-62578

N,N′-Disuccinimidyl Carbonate

Producto controlado

CAS: 74124-79-1

Stability Moisture Sensitive
Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.
References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);

Fórmula: C₉H₈N₂O₇

Forma y color: Neat

Peso molecular: 256.17

Ref: TR-D493540