CAS 74150-27-9
:Pimobendan
Descripción:
Pimobendan es un compuesto farmacéutico utilizado principalmente en medicina veterinaria, particularmente para el tratamiento de la insuficiencia cardíaca congestiva en perros. Funciona como un agente inotrópico positivo, mejorando la contractilidad del corazón, y también actúa como un vasodilatador, lo que ayuda a reducir la carga de trabajo del corazón. La estructura química de Pimobendan incluye un núcleo de benzazepina, y se clasifica como un inhibidor de la fosfodiesterasa III, lo que contribuye a su mecanismo de acción al aumentar los niveles de AMP cíclico intracelular. Esto resulta en una mejoría del gasto cardíaco y una reducción de la congestión pulmonar. Pimobendan se administra típicamente por vía oral y se absorbe bien, con una vida media relativamente larga, lo que permite una dosificación una o dos veces al día. Su perfil de seguridad es generalmente favorable, aunque los efectos secundarios potenciales pueden incluir trastornos gastrointestinales y arritmias. Como medicamento veterinario, es crucial usar Pimobendan bajo la guía de un veterinario para asegurar una dosificación y monitoreo apropiados de la respuesta del animal al tratamiento.
Fórmula:C19H18N4O2
InChI:InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
Clave InChI:InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES:CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1
Sinónimos:- (±)-Ud Cg 115Bs
- 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- Acardi
- Pimobenda
- Racemic pimobendan
- Ud Cg 115 Bs
- Ud-Cg 115
- Vetmedin
- Ver más sinónimos
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Encontrado 16 productos.
Pimobendan
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFórmula:C19H18N4O2Forma y color:White Yellow PowderPeso molecular:334.14298Pimobendan
CAS:<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Fórmula:C19H18N4O2Pureza:99.91%Forma y color:SolidPeso molecular:334.376-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One
CAS:6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-OneFórmula:C19H18N4O2Pureza:99%Forma y color: white to almost white crsytal to powderPeso molecular:334.37g/molPimobendan 100 µg/mL in Acetonitrile
CAS:Fórmula:C19H18N4O2Forma y color:Single SolutionPeso molecular:334.37Pimobendan
CAS:Fórmula:C19H18N4O2Pureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:334.38Pimobendan-d3
CAS:Producto controlado<p>Applications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Fórmula:C19H15D3N4O2Forma y color:White To Light YellowPeso molecular:337.39rac Pimobendan
CAS:Producto controlado<p>Applications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Fórmula:C19H18N4O2Forma y color:NeatPeso molecular:334.37Pimobendan
CAS:<p>Pimobendan is a drug that has been shown to have positive effects on the cardiac function of experimental animals. It is a selective inhibitor of the enzyme phosphodiesterase 3 in cardiac tissues. Pimobendan also has effects on blood pressure, as it increases systolic pressure and decreases diastolic pressure. The pharmacokinetic properties of pimobendan are characterized by a concentration-time curve with a long terminal half-life. Pimobendan is also an ATP-sensitive K+ channel blocker, which causes increased intracellular K+ concentrations in the myocardium. This leads to an increase in cardiac contractility and relaxation, with an improvement in cardiac performance. Chronic oral administration of pimobendan has been shown to be effective in improving the long-term efficacy of treatment for congestive heart failure due to chronic valvular disease or dilated cardiomyopathy.</p>Fórmula:C19H18N4O2Pureza:Min. 95%Forma y color:White PowderPeso molecular:334.37 g/mol
![6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1011940.jpg&w=3840&q=75)
