CAS 74863-84-6

Argatroban

Descripción:

Argatroban es un inhibidor sintético directo de la trombina utilizado principalmente como anticoagulante en entornos clínicos, particularmente para pacientes con trombocitopatía inducida por heparina (HIT). Es una molécula pequeña que se une selectivamente al sitio activo de la trombina, impidiendo la conversión de fibrinógeno a fibrina, lo cual es crucial en el proceso de coagulación. Argatroban se administra por vía intravenosa y tiene un inicio de acción rápido, lo que lo hace adecuado para situaciones agudas. Su farmacocinética se caracteriza por una vida media corta, lo que requiere infusión continua para una anticoagulación sostenida. La sustancia se metaboliza principalmente en el hígado, y sus efectos se pueden monitorear utilizando pruebas de tiempo de tromboplastina parcial activada (aPTT). Los efectos secundarios comunes incluyen complicaciones hemorrágicas, que son un riesgo asociado con todos los anticoagulantes. Argatroban también es notable por su falta de reactividad cruzada con heparina, lo que lo convierte en una opción preferida para pacientes con antecedentes de HIT. En general, su mecanismo y propiedades únicos lo convierten en un agente terapéutico importante en el manejo de trastornos trombóticos.

Fórmula: C₂₃H₃₆N₆O₅S

InChI: InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1

Clave InChI: InChIKey=KXNPVXPOPUZYGB-IOVMHBDKSA-N

SMILES: S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3

Sinónimos:

• (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid
• (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
• (2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
• (2R,4R)-1-[N~5~-(diaminomethylidene)-N~2~-{[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-ornithyl]-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-4-Methyl-1-[N-[(3-Methyl-1,2,3,4-Tetrahydro-8-Quinolinyl)Sulfonyl]-L-Arginyl]-2-Piperidinecarboxylic Acid
• 2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, (2R-(1(S*(R*)),2alpha,4beta))-
• 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-
• 2-Piperidinecarboxylic acid, 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, [2R-[1(2S*),2α,4β]]-[partial]-
• 21R-
• Acova
• Argatra
• Argatroban
• Argatroban Monohydrate
• Argipidin
• Argipidine
• Dk 7419
• Gn 1600
• Gn1600
• Mci 9038
• Md 805
• Novastan
• Om 805
• Slonnon

Argatroban Monohydrate

CAS: 141396-28-3, 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S·H₂O

Pureza: >99.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 526.66

Ref: 3B-A2705

(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

CAS: 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: 98%

Forma y color: Solid

Peso molecular: 508.6341

Ref: IN-DA0038G0

Argatroban (Mixture of Diastereomers)

CAS: 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S

Forma y color: White To Off-White Solid

Peso molecular: 508.64

Ref: 4Z-A-591

Argatroban

CAS: 74863-84-6

Argatroban

Pureza: ≥98%

Peso molecular: 508.63g/mol

Ref: 54-BUP15629

Argatroban

CAS: 74863-84-6

Fórmula: C₂₃H₃₈N₆O₆S

Pureza: (HPLC) ≥ 98%

Forma y color: White to off-white powder

Peso molecular: 526.65

Ref: 7W-GP6176

Argatroban

CAS: 74863-84-6

Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: 99.77% - >99.99%

Forma y color: White To Off-White Crystalline Solid

Peso molecular: 508.63

Ref: TM-T0155

Argatroban

Producto controlado

CAS: 74863-84-6

Applications Synthetic thrombin inhibitor. Antithrombotic.
References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),

Fórmula: C₂₃H₃₆N₆O₅S

Forma y color: White Powder

Peso molecular: 508.63

Ref: TR-A769000

Argatroban

CAS: 74863-84-6

Argatroban is a drug that belongs to the group of anticoagulants and is used in the treatment of blood disorders. Argatroban is an oral prodrug that undergoes hepatic metabolism to its active form, argatroban. Argatroban is a thrombin inhibitor that competes with heparin for binding to antithrombin III and thrombin, thereby preventing the formation of fibrin clots. Argatroban has been shown to be successful in treating patients with congestive heart failure or nephrology dialysis who are at risk for developing deep vein thrombosis. This drug also has a long half-life and does not require frequent monitoring, making it suitable for use in these patient populations. However, argatroban should not be used if there is hepatic impairment or if the patient has undergone recent cerebral surgery due to the risk of brain infarction.

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: Min. 95%

Forma y color: Off-White Powder

Peso molecular: 508.64 g/mol

Ref: 3D-FA17976