CAS 7542-37-2

Paromomicina

Descripción:

Paromomicina es un antibiótico aminoglucósido que se utiliza principalmente para tratar infecciones causadas por ciertos parásitos y bacterias. Se deriva de la bacteria Streptomyces griseus y es particularmente efectivo contra infecciones protozoarias como la leishmaniasis y la amebiasis. Paromomicina actúa uniéndose a la subunidad ribosomal 30S de las bacterias, inhibiendo la síntesis de proteínas, lo que finalmente conduce a la muerte celular bacteriana. El compuesto se caracteriza por su toxicidad relativamente baja en comparación con otros aminoglucósidos, lo que lo hace adecuado para su uso en poblaciones específicas, incluidas las mujeres embarazadas para ciertas infecciones. Paromomicina se administra típicamente por vía oral o intramuscular, dependiendo de la condición que se esté tratando. Su solubilidad en agua permite una fácil formulación en diversas preparaciones farmacéuticas. Sin embargo, es importante monitorear los posibles efectos secundarios, incluidos los trastornos gastrointestinales y la nefrotoxicidad, especialmente en pacientes con condiciones renales preexistentes. En general, Paromomicina sigue siendo un agente terapéutico valioso en el tratamiento de enfermedades infecciosas específicas.

Fórmula: C₂₃H₄₅N₅O₁₄

InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

Clave InChI: InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N

SMILES: O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinónimos:

• (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
• 231-423-0
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-
• Aminosidin
• Aminosidine
• Aminosidine I
• Amminosidin
• Antibiotic 2230D
• Antibiotic 503-3
• Antibiotic SF 767B
• Catenulin
• Crestomycin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
• Gabbromicina
• Gabbromycin
• Gabromycin
• Humycin
• Hydroxymycin
• Monomycin A
• Neomycin E
• O-2,6-Diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Paromomicina
• Paromomycin I
• Paromomycine
• Paucimycin
• Quintomycin C
• R 400
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• Zygomycin A1
• Zygomycin A₁

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: >92.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin Deuterated Acetic Acid Salt

Producto controlado

CAS: 7542-37-2

Applications Paromomycin Deuterated Acetic Acid Salt is the isotope labelled analog of Paromomycin Sulfate. Paromomycin Sulfate is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Fórmula: C₂₃H₄₅N₅O₁₄•5(CH₃COOH)forundeuterated

Forma y color: Neat

Peso molecular: 615.63

Ref: TR-P205653

Aminosidine

CAS: 7542-37-2

Aminosidine is a nucleoside analogue that inhibits the HIV-1 reverse transcriptase and the integrase, which are enzymes involved in viral DNA synthesis. Aminosidine is active against Leishmania spp., but not against bacteria. Aminosidine has been shown to be effective in experimental models of human bowel disease and in patients with inflammatory bowel disease. It was also found to be active against wild-type strains of human immunodeficiency virus type 1, but not resistant mutants. The mechanism of action is the inhibition of cellular mitochondrial membrane potential.

Pureza: Min. 95%

Ref: 3D-OA11590

Neomycin EP Impurity E

CAS: 7542-37-2

Fórmula: C₂₃H₄₅N₅O₁₄

Peso molecular: 615.63

Ref: ST-EA-CP-N53012